5VNS

M.tb Antigen 85C Acyl-Enzyme Intermediate with Tetrahydrolipstatin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5vnsa_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Mycobacterial antigens	automated matches	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Mycobacterial antigens	8084047	4000704	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	alpha/beta-Hydrolases	8084048	3000102	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	alpha/beta-Hydrolases	8032500	3000102	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hydrolase_4	e5vnsA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00756	Putative esterase (Esterase)	Putative esterase	This family contains Esterase D Swiss:P10768. However it is not clear if all members of the family have the same function. This family is related to the Pfam:PF00135 family.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Diacylglycerol acyltransferase/mycolyltransferase Ag85C	diacylglycerol O-acyltransferase activity O-acyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity acylglycerol O-acyltransferase activity trehalose O-mycolyltransferase activity protein binding binding enzyme binding zymogen binding	carbohydrate derivative biosynthetic process membrane lipid metabolic process glycolipid metabolic process liposaccharide metabolic process carbohydrate derivative metabolic process lipid biosynthetic process glycolipid biosynthetic process primary metabolic process biosynthetic process metabolic process cellular process membrane lipid biosynthetic process lipid metabolic process localization carbohydrate derivative biosynthetic process membrane lipid metabolic process glycolipid metabolic process liposaccharide metabolic process carbohydrate derivative metabolic process lipid biosynthetic process glycolipid biosynthetic process primary metabolic process biosynthetic process metabolic process cellular process membrane lipid biosynthetic process lipid metabolic process localization transport macromolecule localization lipid localization lipid transport establishment of localization response to stimulus response to chemical response to antibiotic mycolate cell wall layer assembly cellular component biogenesis cellular component organization peptidoglycan-based cell wall biogenesis cellular component assembly cell wall biogenesis cell wall organization or biogenesis Actinobacterium-type cell wall biogenesis cellular component organization or biogenesis	cellular anatomical structure extracellular region cell periphery external encapsulating structure cell wall peptidoglycan-based cell wall

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR050583	Mycobacterial A85 antigen	Family
A	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A	IPR000801	Esterase-like	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Monotopic/peripheral	Alpha/Beta monotopic/peripheral	Alpha/beta-hydrolases	Mycobacterial antigens

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.