5M8T

Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with tropolone

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Tyrosinase	e5m8tA1	A: alpha arrays	X: Di-copper centre-containing domain (From Topology)	H: Di-copper centre-containing domain (From Topology)	T: Di-copper centre-containing domain	F: Tyrosinase	ECOD (1.6)
B	Tyrosinase	e5m8tB1	A: alpha arrays	X: Di-copper centre-containing domain (From Topology)	H: Di-copper centre-containing domain (From Topology)	T: Di-copper centre-containing domain	F: Tyrosinase	ECOD (1.6)
D	Tyrosinase	e5m8tD1	A: alpha arrays	X: Di-copper centre-containing domain (From Topology)	H: Di-copper centre-containing domain (From Topology)	T: Di-copper centre-containing domain	F: Tyrosinase	ECOD (1.6)
C	Tyrosinase	e5m8tC1	A: alpha arrays	X: Di-copper centre-containing domain (From Topology)	H: Di-copper centre-containing domain (From Topology)	T: Di-copper centre-containing domain	F: Tyrosinase	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00264	Common central domain of tyrosinase (Tyrosinase)	Common central domain of tyrosinase	This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to Pfam:PF00372.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	5,6-dihydroxyindole-2-carboxylic acid oxidase	oxidoreductase activity catalytic activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen monooxygenase activity tyrosinase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen cation binding ion binding metal ion binding oxidoreductase activity catalytic activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen monooxygenase activity tyrosinase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen cation binding ion binding metal ion binding small molecule binding	vesicle organization cellular component organization melanosome organization organelle organization pigmentation cellular pigmentation cellular process cellular component organization or biogenesis pigment granule organization fatty acid metabolic process oxoacid metabolic process short-chain fatty acid metabolic process acetoacetic acid metabolic process carboxylic acid metabolic process vesicle organization cellular component organization melanosome organization organelle organization pigmentation cellular pigmentation cellular process cellular component organization or biogenesis pigment granule organization fatty acid metabolic process oxoacid metabolic process short-chain fatty acid metabolic process acetoacetic acid metabolic process carboxylic acid metabolic process primary metabolic process generation of precursor metabolites and energy organic acid metabolic process fatty acid derivative metabolic process ketone body metabolic process metabolic process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process developmental process pigment cell differentiation cellular developmental process cell differentiation developmental pigmentation melanocyte differentiation pigment metabolic process regulation of melanin biosynthetic process regulation of cellular process organic hydroxy compound metabolic process positive regulation of biological process pigment biosynthetic process melanin metabolic process secondary metabolic process positive regulation of secondary metabolite biosynthetic process positive regulation of metabolic process secondary metabolite biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process biological regulation positive regulation of melanin biosynthetic process regulation of secondary metabolite biosynthetic process regulation of secondary metabolic process biosynthetic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process phenol-containing compound biosynthetic process melanin biosynthetic process regulation of metabolic process	membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle bounding membrane of organelle vesicle membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle bounding membrane of organelle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane membrane clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle membrane endosome membrane endosome endomembrane system chitosome melanosome membrane pigment granule membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR002227	Tyrosinase copper-binding domain	Domain
A, B, C, D	IPR008922	Di-copper centre-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR050316	Tyrosinase and Hemocyanin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P17643	melanoma oculocutaneous albinism type 3 oculocutaneous albinism adenocarcinoma tubular adenocarcinoma granular cell carcinoma pilocytic astrocytoma squamous cell carcinoma Albinism, Ocular cribriform carcinoma cutaneous melanoma lung benign neoplasm malignant mesothelioma non-small cell lung carcinoma oligodendroglioma melanoma oculocutaneous albinism type 3 oculocutaneous albinism adenocarcinoma tubular adenocarcinoma granular cell carcinoma pilocytic astrocytoma squamous cell carcinoma Albinism, Ocular cribriform carcinoma cutaneous melanoma lung benign neoplasm malignant mesothelioma non-small cell lung carcinoma oligodendroglioma primitive neuroectodermal tumor cribriform carcinoma of breast glioblastoma intellectual disability pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis astrocytic tumor cutaneous lupus erythematosus lung adenocarcinoma malignant ependymoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.