5K6S | pdb_00005k6s

The structure of the PP2A B56 subunit BubR1 complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8043105	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	B56	e5k6sA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: B56	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	phosphoric ester hydrolase activity enzyme regulator activity protein phosphatase activator activity catalytic activity, acting on a protein phosphatase activator activity molecular function activator activity phosphatase activity phosphatase regulator activity hydrolase activity phosphoprotein phosphatase activity enzyme activator activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity catalytic activity phosphoric ester hydrolase activity enzyme regulator activity protein phosphatase activator activity catalytic activity, acting on a protein phosphatase activator activity molecular function activator activity phosphatase activity phosphatase regulator activity hydrolase activity phosphoprotein phosphatase activity enzyme activator activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity catalytic activity	negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process cellular process cellular response to stimulus response to stimulus signaling signal transduction by p53 class mediator cell death negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process cellular process cellular response to stimulus response to stimulus signaling signal transduction by p53 class mediator cell death intracellular signal transduction intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator cell communication apoptotic signaling pathway cellular response to stress DNA damage response response to stress intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage signal transduction apoptotic process intrinsic apoptotic signaling pathway programmed cell death catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process macromolecule metabolic process protein metabolic process	phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system cytosol membraneless organelle chromosome, centromeric region intracellular membraneless organelle chromosome chromosomal region nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B	BubR1	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity histone H3S57 kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H3 kinase activity histone modifying activity catalytic activity histone kinase activity histone H2AS121 kinase activity histone H2A kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity histone H3S57 kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H3 kinase activity histone modifying activity catalytic activity histone kinase activity histone H2AS121 kinase activity histone H2A kinase activity Rho-dependent protein serine/threonine kinase activity AMP-activated protein kinase activity histone H2AT120 kinase activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein serine kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T11 kinase activity histone H3S28 kinase activity histone H3T6 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2B kinase activity histone H2BS36 kinase activity histone H3T3 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity histone H2BS14 kinase activity	chromosome organization sister chromatid cohesion meiotic sister chromatid cohesion, centromeric cellular component organization centromeric sister chromatid cohesion organelle organization cellular process cellular component organization or biogenesis cell cycle meiotic sister chromatid cohesion cell cycle process cell division protein localization localization chromosome organization sister chromatid cohesion meiotic sister chromatid cohesion, centromeric cellular component organization centromeric sister chromatid cohesion organelle organization cellular process cellular component organization or biogenesis cell cycle meiotic sister chromatid cohesion cell cycle process cell division protein localization localization cellular localization protein localization to chromosome, centromeric region protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction mitotic sister chromatid separation chromosome segregation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling regulation of biological process negative regulation of cellular component organization regulation of cell cycle process sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle signaling spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle regulation of mitotic cell cycle negative regulation of cellular process mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition regulation of cell cycle negative regulation of chromosome separation mitotic nuclear division negative regulation of mitotic cell cycle phase transition organelle fission biological regulation negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling nuclear division negative regulation of chromosome segregation negative regulation of nuclear division negative regulation of organelle organization chromosome separation regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition apoptotic process cell death programmed cell death	intracellular organelle centrosome microtubule organizing center cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cytoplasm cytosol protein-containing complex chromosome intracellular organelle centrosome microtubule organizing center cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cytoplasm cytosol protein-containing complex chromosome chromosomal region kinetochore chromosome, centromeric region outer kinetochore condensed chromosome, centromeric region supramolecular complex condensed chromosome membrane-bounded organelle ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex perinuclear region of cytoplasm spindle mitotic checkpoint complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR002554	Protein phosphatase 2A, regulatory B subunit, B56	Family
A	IPR011989	Armadillo-like helical	Homologous Superfamily
B	IPR015661	Mitotic spindle checkpoint protein Bub1/Mad3	Family
B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B	IPR013212	Mad3/Bub1 homology region 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q13362	B-cell chronic lymphocytic leukemia Chromosomal Instability astrocytic tumor dermatomyositis gastric carcinoma lymphoplasmacytic lymphoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma Pick disease thyroid gland papillary carcinoma interstitial cystitis malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis B-cell chronic lymphocytic leukemia Chromosomal Instability astrocytic tumor dermatomyositis gastric carcinoma lymphoplasmacytic lymphoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma Pick disease thyroid gland papillary carcinoma interstitial cystitis malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis tuberculosis familial nonmedullary thyroid carcinoma large cell medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
B	Pharos: O60566	premature chromatid separation trait esophageal squamous cell carcinoma mosaic variegated aneuploidy syndrome colorectal cancer embryonal rhabdomyosarcoma microcephaly mosaic variegated aneuploidy syndrome 1 germ cell tumor embryonal neoplasm pancreatic intraductal papillary-mucinous carcinoma Germ Cell Cancer rhabdomyosarcoma hydrocephalus adrenal cortex carcinoma interstitial cystitis premature chromatid separation trait esophageal squamous cell carcinoma mosaic variegated aneuploidy syndrome colorectal cancer embryonal rhabdomyosarcoma microcephaly mosaic variegated aneuploidy syndrome 1 germ cell tumor embryonal neoplasm pancreatic intraductal papillary-mucinous carcinoma Germ Cell Cancer rhabdomyosarcoma hydrocephalus adrenal cortex carcinoma interstitial cystitis B-cell chronic lymphocytic leukemia lung adenocarcinoma cancer malignant glioma medulloblastoma cataract nasopharyngeal carcinoma cystic fibrosis non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm genetic endocrine growth disease primitive neuroectodermal tumor heart disease IgA glomerulonephritis atopic eczema invasive ductal breast carcinoma breast cancer lung cancer malignant mesothelioma colorectal carcinoma ductal breast carcinoma in situ ovarian cancer endometriosis pituitary cancer psoriasis glioblastoma sinusitis hepatocellular carcinoma intellectual disability atypical teratoid rhabdoid tumor large cell medulloblastoma breast carcinoma malignant ependymoma malignant pancreatic neoplasm microlissencephaly chronic kidney disease myocardial infarction

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.