5I22 | pdb_00005i22

Amphiphysin SH3 in complex with Chikungunya virus nsP3 peptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5i22a_	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH3_1	e5i22A1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14604	Variant SH3 domain (SH3_9)	Variant SH3 domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Myc box-dependent-interacting protein 1	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding phospholipid binding lipid binding protein-folding chaperone binding tau protein binding identical protein binding clathrin binding protein-macromolecule adaptor activity molecular adaptor activity cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding phospholipid binding lipid binding protein-folding chaperone binding tau protein binding identical protein binding clathrin binding protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity enzyme binding protease binding RNA polymerase binding GTPase binding enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein hydrolase activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity aspartic-type peptidase activity molecular function inhibitor activity molecular function regulator activity aspartic-type endopeptidase activity aspartic-type endopeptidase inhibitor activity catalytic activity endopeptidase activity	negative regulation of hydrolase activity amyloid precursor protein catabolic process regulation of cellular process negative regulation of proteolysis regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of amyloid precursor protein catabolic process negative regulation of endopeptidase activity regulation of primary metabolic process negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of amyloid precursor protein catabolic process negative regulation of peptidase activity regulation of proteolysis proteolysis negative regulation of hydrolase activity amyloid precursor protein catabolic process regulation of cellular process negative regulation of proteolysis regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of amyloid precursor protein catabolic process negative regulation of endopeptidase activity regulation of primary metabolic process negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of amyloid precursor protein catabolic process negative regulation of peptidase activity regulation of proteolysis proteolysis regulation of endopeptidase activity negative regulation of cellular process protein metabolic process amyloid precursor protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation regulation of peptidase activity negative regulation of molecular function primary metabolic process regulation of macromolecule metabolic process regulation of molecular function regulation of hydrolase activity metabolic process cellular process macromolecule metabolic process regulation of metabolic process positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process regulation of localization regulation of potassium ion transport transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport potassium ion transmembrane transport negative regulation of transport regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport monoatomic cation transmembrane transport localization negative regulation of monoatomic ion transmembrane transport monoatomic ion transport negative regulation of cation transmembrane transport monoatomic cation transport regulation of metal ion transport negative regulation of potassium ion transport regulation of transport regulation of monoatomic ion transport inorganic ion transmembrane transport negative regulation of potassium ion transmembrane transport regulation of potassium ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport cellular component organization organelle organization cellular component organization or biogenesis cytoskeleton organization regulation of amide metabolic process regulation of amyloid-beta formation amyloid-beta metabolic process amide metabolic process amyloid-beta formation negative regulation of amyloid-beta formation negative regulation of amide metabolic process nucleus organization RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process membrane organization developmental process cellular developmental process cell development muscle cell differentiation muscle structure development T-tubule organization muscle cell development cell differentiation plasma membrane organization anatomical structure development endomembrane system organization heart process multicellular organismal process system process regulation of heart contraction regulation of system process circulatory system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process regulation of biological quality regulation of heart rate by cardiac conduction heart contraction blood circulation regulation of heart rate synaptic vesicle endocytosis import into cell cellular localization synaptic vesicle cycle vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling establishment of localization in cell endocytosis endosome to lysosome transport intracellular transport lysosomal transport vacuolar transport regulation of cell cycle process cell cycle regulation of cell cycle cell cycle process regulation of ventricular cardiac muscle cell action potential cardiac muscle contraction negative regulation of muscle contraction regulation of cardiac muscle cell action potential actin filament-based process negative regulation of cardiac muscle contraction regulation of action potential cardiac muscle cell contraction ventricular cardiac muscle cell action potential action potential regulation of cardiac muscle contraction muscle contraction regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction negative regulation of multicellular organismal process regulation of membrane potential cardiac muscle cell action potential involved in contraction regulation of actin filament-based process negative regulation of action potential striated muscle contraction negative regulation of blood circulation actin filament-based movement muscle system process regulation of muscle system process negative regulation of heart contraction negative regulation of ventricular cardiac muscle cell action potential negative regulation of cardiac muscle cell contraction regulation of cardiac muscle cell contraction actin-mediated cell contraction cardiac muscle cell action potential negative regulation of striated muscle contraction organelle localization nucleus localization positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization positive regulation of cellular component organization regulation of cellular component size cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly positive regulation of protein polymerization protein-containing complex assembly regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin cytoskeleton organization actin filament polymerization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization regulation of actin polymerization or depolymerization actin filament organization regulation of cellular component biogenesis positive regulation of supramolecular fiber organization regulation of organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization positive regulation of actin filament polymerization regulation of anatomical structure size regulation of developmental process regulation of cell differentiation nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation regulation of neuron differentiation system development lipid tube assembly protein-lipid complex organization protein-lipid complex assembly regulation of calcium ion transport calcium ion transport regulation of calcium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of calcium ion transport negative regulation of calcium ion transmembrane transport calcium ion transmembrane transport biological process involved in interspecies interaction between organisms response to stimulus response to lipid response to other organism response to oxygen-containing compound response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to chemical response to external biotic stimulus response to molecule of bacterial origin regulation of vesicle-mediated transport positive regulation of endocytosis positive regulation of transport regulation of endocytosis positive regulation of nervous system development astrocyte differentiation regulation of neurogenesis regulation of gliogenesis regulation of astrocyte differentiation positive regulation of gliogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process gliogenesis positive regulation of cell differentiation positive regulation of neurogenesis positive regulation of astrocyte differentiation regulation of multicellular organismal development positive regulation of cell development regulation of glial cell differentiation positive regulation of glial cell differentiation central nervous system development glial cell differentiation positive regulation of multicellular organismal process	cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex membrane-bounded organelle organelle envelope nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cytoskeleton actin cytoskeleton cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection axon main axon axon initial segment synapse cell junction glutamatergic synapse RNA polymerase II transcription repressor complex protein-containing complex nuclear protein-containing complex transcription regulator complex transcription repressor complex postsynapse transport vesicle intracellular vesicle presynapse cytoplasmic vesicle synaptic vesicle secretory vesicle vesicle exocytic vesicle varicosity node of Ranvier extrinsic component of synaptic vesicle membrane transport vesicle membrane extrinsic component of organelle membrane bounding membrane of organelle vesicle membrane synaptic vesicle membrane exocytic vesicle membrane cytoplasmic vesicle membrane organelle membrane extrinsic component of membrane lipid tube protein-lipid complex endosome axon terminus distal axon neuron projection terminus cerebellar mossy fiber
B	CHIKV nsP3 peptide	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity molecular carrier activity cysteine-type peptidase activity peptidase activity hydrolase activity pyrophosphatase activity catalytic activity, acting on RNA hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides mRNA 5'-triphosphate monophosphatase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding poly(A) RNA polymerase activity adenylyltransferase activity transferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups nucleic acid conformation isomerase activity isomerase activity helicase activity RNA helicase activity ATP-dependent activity, acting on RNA macromolecular conformation isomerase activity cation binding metal ion binding RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity RNA polymerase activity cohesin loader activity DNA clamp loader activity ATP-dependent H2AZ histone chaperone activity RNA methyltransferase activity transferase activity, transferring one-carbon groups methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity mRNA methyltransferase activity RNA binding nucleic acid binding guanyl nucleotide binding GTP binding guanyl ribonucleotide binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds polynucleotide 5'-phosphatase activity phosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity	RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process viral genome replication biosynthetic process viral RNA genome replication viral process metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process viral genome replication biosynthetic process viral RNA genome replication viral process metabolic process cellular process macromolecule metabolic process symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host gene expression biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host gene expression modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction mRNA modification mRNA metabolic process RNA modification macromolecule modification symbiont-mediated suppression of host JAK-STAT cascade symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity symbiont-mediated perturbation of host signal transduction pathway methylation gene expression DNA-templated transcription symbiont-mediated perturbation of host defense response symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated perturbation of host immune response symbiont-mediated perturbation of host innate immune response symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host transcription symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity symbiont-mediated perturbation of host transcription regulation of cytoskeleton organization regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation regulation of organelle organization cellular component organization organelle organization cellular component organization or biogenesis cytoskeleton organization 7-methylguanosine mRNA capping 7-methylguanosine RNA capping RNA capping mRNA processing RNA 5'-end processing RNA processing proteolysis protein metabolic process	cellular anatomical structure membrane host cellular component host cell part host cell filopodium host cell projection host cell plasma membrane host cell membrane host intracellular membrane-bounded organelle host intracellular part host cell cytoplasmic vesicle membrane host cell cytoplasm part host intracellular organelle host cell cytoplasmic vesicle cellular anatomical structure membrane host cellular component host cell part host cell filopodium host cell projection host cell plasma membrane host cell membrane host intracellular membrane-bounded organelle host intracellular part host cell cytoplasmic vesicle membrane host cell cytoplasm part host intracellular organelle host cell cytoplasmic vesicle host cell cytoplasm host intracellular region host cell nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR001452	SH3 domain	Domain
A	IPR003005	Amphiphysin	Family
A	IPR004148	BAR domain	Domain
A	IPR003023	Amphiphysin 2	Family
A	IPR035471	Amphiphysin 2, SH3 domain	Domain
A	IPR027267	AH/BAR domain superfamily	Homologous Superfamily
B	IPR047311	RNA-dependent RNA polymerase, togavirus	Domain
B	IPR048891	Non-structural protein 3, zinc-binding domain	Domain
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR002620	Alphavirus nsp2 protease domain	Domain
B	IPR002588	Alphavirus-like methyltransferase domain	Domain
B	IPR044936	Alphavirus nsP2 protease domain superfamily	Homologous Superfamily
B	IPR049329	Tomato mosaic virus helicase, N-terminal domain	Domain
B	IPR027351	(+) RNA virus helicase core domain	Domain
B	IPR002589	Macro domain	Domain
B	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
B	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
B	IPR001788	RNA-dependent RNA polymerase, alsuviricetes	Domain
B	IPR043472	Macro domain-like	Homologous Superfamily
B	IPR044371	Non-structural protein 3, X-domain-like	Domain
B	IPR007094	RNA-directed RNA polymerase, catalytic domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O00499	Alzheimer disease centronuclear myopathy myopathy, centronuclear, 2 autosomal dominant centronuclear myopathy congenital structural myopathy glioblastoma malignant ependymoma muscle tissue disease Acute Confusional Senile Dementia tubular aggregate myopathy breast fibroadenoma esophageal adenocarcinoma intellectual disability malignant glioma muscular disease Alzheimer disease centronuclear myopathy myopathy, centronuclear, 2 autosomal dominant centronuclear myopathy congenital structural myopathy glioblastoma malignant ependymoma muscle tissue disease Acute Confusional Senile Dementia tubular aggregate myopathy breast fibroadenoma esophageal adenocarcinoma intellectual disability malignant glioma muscular disease adenoma psoriasis X-linked centronuclear myopathy arthrogryposis invasive ductal breast carcinoma medulloblastoma myopathy ovarian cancer adrenal cortex carcinoma spina bifida atypical teratoid rhabdoid tumor autosomal recessive centronuclear myopathy congenital fiber-type disproportion myopathy ductal breast carcinoma in situ