Annotations: 5HTL

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	nfrB	e5htlB2	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: nfrB	ECOD (1.6)
B	T2SSE_N	e5htlB1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: T2SSE_N	ECOD (1.6)
A	nfrB	e5htlA1	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: nfrB	ECOD (1.6)
A	T2SSE_N	e5htlA2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: T2SSE_N	ECOD (1.6)

Chains	Accession	Name	Description	Comments	Source
A, B	PF05157	MshEN domain (MshEN)	MshEN domain	This domain is found at the N-terminus of the Type II secretion secretion system protein E (GspE) and type IV pilus extensin ATPase PilB and near the C-terminus of the glycosyltransferase NfrB. A variant of this domain, called MshEN, binds cyclic di- ...	This domain is found at the N-terminus of the Type II secretion secretion system protein E (GspE) and type IV pilus extensin ATPase PilB and near the C-terminus of the glycosyltransferase NfrB. A variant of this domain, called MshEN, binds cyclic di-GMP [4,6,7], which modulates the activity of the respective protein. The structure of this domain is now known [1,2,4].	Domain

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	MSHA biogenesis protein MshE	pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	-	cell periphery cellular anatomical structure plasma membrane membrane

Chains	Accession	Name	Type
A, B	IPR001482	Type II/IV secretion system domain	Domain
A, B	IPR003593	AAA+ ATPase domain	Domain
A, B	IPR037257	Type II secretion system protein GspE, N-terminal superfamily	Homologous Superfamily
A, B	IPR007831	Type II secretion system protein GspE, N-terminal	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily