5WRJ

Crystal structure of human tyrosylprotein sulfotransferase-1 complexed with PAP and gastrin peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8105344	3002021	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8105344	3002021	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8105344	3002021	SCOP2B (2022-06-29)
A	SCOP2 Family	Tyrosylprotein sulfotransferase (TPST)-like	8066257	4006221	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	P-loop nucleotide/nucleoside kinase-like	8105344	3002021	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Sulfotransfer_1	e5wrjB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Sulfotransfer_1	ECOD (1.6)
C	Sulfotransfer_1	e5wrjC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Sulfotransfer_1	ECOD (1.6)
D	Sulfotransfer_1	e5wrjD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Sulfotransfer_1	ECOD (1.6)
A	Sulfotransfer_1	e5wrjA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Sulfotransfer_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
D	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF13469	Sulfotransferase family (Sulfotransfer_3)	Sulfotransferase family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Protein-tyrosine sulfotransferase 1	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity catalytic activity, acting on a protein transferase activity, transferring sulphur-containing groups sulfotransferase activity transferase activity catalytic activity protein-tyrosine sulfotransferase activity	macromolecule modification metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process oxoacid metabolic process carbohydrate derivative metabolic process macromolecule modification metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process oxoacid metabolic process carbohydrate derivative metabolic process organic acid metabolic process purine ribonucleoside bisphosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process phosphorus metabolic process nucleoside phosphate metabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process nucleotide metabolic process purine-containing compound metabolic process organophosphate metabolic process purine ribonucleotide metabolic process peptidyl-tyrosine sulfation peptidyl-tyrosine modification sulfation protein sulfation peptidyl-amino acid modification	cellular anatomical structure membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system Golgi membrane bounding membrane of organelle organelle membrane
E [auth F], F [auth H], G [auth J], H [auth L]	gastrin peptide	hormone activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation G protein-coupled receptor signaling pathway cellular process signal transduction cell communication response to nutrient levels response to food response to chemical	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR026634	Protein-tyrosine sulfotransferase-like	Family
A, B, C, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E [auth F], F [auth H], G [auth J], H [auth L]	IPR001651	Gastrin/cholecystokinin peptide hormone	Domain
E [auth F], F [auth H], G [auth J], H [auth L]	IPR013152	Gastrin/cholecystokinin, conserved site	Conserved Site
E [auth F], F [auth H], G [auth J], H [auth L]	IPR039236	Gastrin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: O60507	atypical teratoid rhabdoid tumor osteosarcoma pilocytic astrocytoma glioblastoma ovarian cancer rheumatoid arthritis large cell medulloblastoma pancreatic ductal adenocarcinoma tuberculosis
E [auth F], F [auth H], G [auth J], H [auth L]	Pharos: P01350	Barrett esophagus granular cell carcinoma adenocarcinoma tubular adenocarcinoma malignant colon neoplasm peptic ulcer disease lung benign neoplasm Malignant neoplasm of lung multiple endocrine neoplasia pernicious anemia cancer colonic neoplasm diabetes mellitus gastritis hereditary diffuse gastric adenocarcinoma Barrett esophagus granular cell carcinoma adenocarcinoma tubular adenocarcinoma malignant colon neoplasm peptic ulcer disease lung benign neoplasm Malignant neoplasm of lung multiple endocrine neoplasia pernicious anemia cancer colonic neoplasm diabetes mellitus gastritis hereditary diffuse gastric adenocarcinoma multiple sclerosis Zollinger-Ellison syndrome carcinoma of esophagus cribriform carcinoma digestive system disease gastric cancer ischemia reperfusion injury squamous cell carcinoma benign colon neoplasm cribriform carcinoma of breast duodenal ulcer gastric neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.