4Y7L

T6SS protein TssM C-terminal domain (869-1107) from EAEC

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AIcmF_C_Ce4y7lA2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: C2 domain (From Topology)T: C2 domainF: IcmF_C_CECOD (1.6)
AIcmF_C_Ne4y7lA1 A: alpha bundlesX: Four-helical up-and-down bundleH: Type VI secretion protein IcmF helical domain (From Topology)T: Type VI secretion protein IcmF helical domainF: IcmF_C_NECOD (1.6)
BIcmF_C_Ce4y7lB1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: C2 domain (From Topology)T: C2 domainF: IcmF_C_CECOD (1.6)
BIcmF_C_Ne4y7lB2 A: alpha bundlesX: Four-helical up-and-down bundleH: Type VI secretion protein IcmF helical domain (From Topology)T: Type VI secretion protein IcmF helical domainF: IcmF_C_NECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF06744Type VI secretion protein IcmF C2-like domain (IcmF_C)Type VI secretion protein IcmF C2-like domainIcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like proteins. It was thought to be involved in Vibrio cholerae cell surface reorganisation that results in increased adherence to epithelial cells leading to an ...IcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like proteins. It was thought to be involved in Vibrio cholerae cell surface reorganisation that results in increased adherence to epithelial cells leading to an increased conjugation frequency [1]. IcmF as a whole interacts with DotU whereby these bind tightly and form the docking area of the T6SS within the inner membrane. The exact function of this domain is not clear [2].
Domain
A, B
PF21070Type VI secretion protein IcmF helical domain (IcmF_helical)Type VI secretion protein IcmF helical domainThis entry represents the alpha-helical domain from the Type VI secretion protein IcmF [1]. This domain is also found in the TssM protein where it forms part of the tip complex [1].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Type VI secretion protein IcmF - -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR048677Type VI secretion system component TssM1, helical domainDomain
A, B
IPR053156Type VI secretion system TssM-likeFamily
A, B
IPR010623Type VI secretion system IcmF, C-terminalDomain