4U3S | pdb_00004u3s

Crystal structure of Coh3ScaB-XDoc_M1ScaA complex: A N-terminal interface mutant of type II Cohesin-X-Dockerin complex from Acetivibrio cellulolyticus

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4u3sa_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Carbohydrate-binding domain	Cellulose-binding domain family III	Cellulosomal scaffoldin adaptor protein B, ScaB	(Acetivibrio cellulolyticus ) [TaxId: 35830 ],	SCOPe (2.08)
B	d4u3sb2	All alpha proteins	Type I dockerin domain	Type I dockerin domain	automated matches	automated matches	(Acetivibrio cellulolyticus ) [TaxId: 35830 ],	SCOPe (2.08)
B	d4u3sb1	All beta proteins	Prealbumin-like	Carboxypeptidase regulatory domain-like	automated matches	automated matches	(Acetivibrio cellulolyticus ) [TaxId: 35830 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Cohesin	e4u3sA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Cohesin	ECOD (1.6)
B	CarboxypepD_reg	e4u3sB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: CarboxypepD_reg	ECOD (1.6)
B	Dockerin_II	e4u3sB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: Type I dockerin domain	F: Dockerin_II	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.680	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
B	2.60.40.1120	Mainly Beta	Sandwich	Immunoglobulin-like	Carboxypeptidase-like, regulatory domain	CATH (4.3.0)
B	1.10.1330.10	Mainly Alpha	Orthogonal Bundle	Type 1 dockerin domain	Dockerin domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00963	Cohesin domain (Cohesin)	Cohesin domain	Cohesin domains interact with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome [1].	Domain
B	PF13620	Carboxypeptidase regulatory-like domain (CarboxypepD_reg)	Carboxypeptidase regulatory-like domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cellulosomal scaffoldin adaptor protein B	binding carbohydrate binding hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity cation binding ion binding metal ion binding small molecule binding	carbohydrate metabolic process polysaccharide metabolic process catabolic process polysaccharide catabolic process carbohydrate catabolic process metabolic process cellular process primary metabolic process macromolecule metabolic process macromolecule catabolic process	cellular anatomical structure extracellular region
B	Cellulosomal scaffoldin	hydrolase activity, acting on glycosyl bonds cellulase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity binding polysaccharide binding cellulose binding carbohydrate binding cation binding ion binding metal ion binding small molecule binding	carbohydrate metabolic process catabolic process glucan catabolic process beta-glucan metabolic process carbohydrate catabolic process primary metabolic process macromolecule catabolic process polysaccharide metabolic process glucan metabolic process beta-glucan catabolic process polysaccharide catabolic process metabolic process cellular process cellulose catabolic process carbohydrate metabolic process catabolic process glucan catabolic process beta-glucan metabolic process carbohydrate catabolic process primary metabolic process macromolecule catabolic process polysaccharide metabolic process glucan metabolic process beta-glucan catabolic process polysaccharide catabolic process metabolic process cellular process cellulose catabolic process macromolecule metabolic process cellulose metabolic process	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002105	Dockerin type I repeat	Repeat
A	IPR051441	Selenoprotein W and related	Family
A	IPR016134	Dockerin domain	Domain
A	IPR036439	Dockerin domain superfamily	Homologous Superfamily
A	IPR008965	CBM2/CBM3, carbohydrate-binding domain superfamily	Homologous Superfamily
A	IPR002102	Cellulosome anchoring protein, cohesin domain	Domain
B	IPR036966	Carbohydrate-binding module 3 superfamily	Homologous Superfamily
B	IPR016134	Dockerin domain	Domain
B	IPR001956	Carbohydrate-binding module 3	Domain
B	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
B	IPR008928	Six-hairpin glycosidase superfamily	Homologous Superfamily
B	IPR008965	CBM2/CBM3, carbohydrate-binding domain superfamily	Homologous Superfamily
B	IPR008969	Carboxypeptidase-like, regulatory domain superfamily	Homologous Superfamily
B	IPR002102	Cellulosome anchoring protein, cohesin domain	Domain
B	IPR012341	Six-hairpin glycosidase-like superfamily	Homologous Superfamily
B	IPR033126	Glycosyl hydrolases family 9, Asp/Glu active sites	Active Site
B	IPR001701	Glycoside hydrolase family 9	Domain
B	IPR036439	Dockerin domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.