Annotations: 4QN9

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Lactamase_B_2	e4qn9B1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_2	ECOD (1.6)
A	Lactamase_B_2	e4qn9A1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF12706	Beta-lactamase superfamily domain (Lactamase_B_2)	Beta-lactamase superfamily domain	This family is part of the beta-lactamase superfamily and is related to Pfam:PF00753.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	bile acid binding organic acid binding binding ion binding anion binding carboxylic acid binding monocarboxylic acid binding small molecule binding phosphoric ester hydrolase activity N-acylphosphatidylethanolamine-specific phospholipase D activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity carboxylic ester hydrolase activity hydrolase activity bile acid binding organic acid binding binding ion binding anion binding carboxylic acid binding monocarboxylic acid binding small molecule binding phosphoric ester hydrolase activity N-acylphosphatidylethanolamine-specific phospholipase D activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity cation binding transition metal ion binding zinc ion binding metal ion binding identical protein binding protein binding	phosphatidylethanolamine metabolic process glycerophospholipid metabolic process primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process amide metabolic process N-acylphosphatidylethanolamine metabolic process phosphorus metabolic process lipid metabolic process regulation of defense response phosphatidylethanolamine metabolic process glycerophospholipid metabolic process primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process amide metabolic process N-acylphosphatidylethanolamine metabolic process phosphorus metabolic process lipid metabolic process regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus defense response biological regulation positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response lipid catabolic process catabolic process phospholipid catabolic process organophosphate catabolic process developmental process fat cell differentiation positive regulation of brown fat cell differentiation regulation of cellular process positive regulation of fat cell differentiation cellular developmental process regulation of developmental process regulation of cell differentiation regulation of brown fat cell differentiation positive regulation of developmental process positive regulation of cell differentiation brown fat cell differentiation cell differentiation regulation of fat cell differentiation positive regulation of cellular process multicellular organismal process biological process involved in interspecies interaction between organisms multicellular organismal-level homeostasis homeostatic process modulation by host of symbiont process homeostasis of number of cells host-mediated regulation of intestinal microbiota composition biological process involved in interaction with symbiont biological process involved in symbiotic interaction temperature homeostasis N-acylethanolamine metabolic process amine metabolic process ethanolamine-containing compound metabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process biogenic amine metabolic process primary alcohol metabolic process diterpenoid metabolic process retinoid metabolic process terpenoid metabolic process isoprenoid metabolic process	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle presynapse presynaptic membrane cytoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen early endosome endosome intracellular vesicle cytoplasmic vesicle neuron to neuron synapse hippocampal mossy fiber to CA3 synapse non-motile cilium cilium 9+0 non-motile cilium neuron projection ciliary membrane photoreceptor outer segment membrane photoreceptor outer segment plasma membrane bounded cell projection cell projection bounding membrane of organelle photoreceptor cell cilium organelle membrane cell projection membrane Golgi apparatus Golgi membrane endosome membrane early endosome membrane cytoplasmic vesicle membrane vesicle membrane smooth endoplasmic reticulum membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum smooth endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001279	Metallo-beta-lactamase	Domain
A, B	IPR024884	N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D	Family
A, B	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q6IQ20	subependymal giant cell astrocytoma astrocytic tumor gastric cancer hepatocellular carcinoma malignant ependymoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis atypical teratoid rhabdoid tumor gastric carcinoma large cell medulloblastoma malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma subependymal giant cell astrocytoma astrocytic tumor gastric cancer hepatocellular carcinoma malignant ependymoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis atypical teratoid rhabdoid tumor gastric carcinoma large cell medulloblastoma malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor ulcerative colitis exocrine pancreatic carcinoma glioblastoma lung carcinoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Monotopic/peripheral	Alpha/Beta monotopic/peripheral	Metallo-beta-lactamase superfamily	N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	MONOTOPIC MEMBRANE PROTEINS	Hydrolases	N-acylphosphatidylethanolamine-hydrolyzing phospholipase D

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.