4MIH

Pyranose 2-oxidase from Phanerochaete chrysosporium, recombinant H158A mutant

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Flavoreductase-like	8087276	3000055	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Flavoreductase-like	8087276	3000055	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Flavoreductase-like	8087276	3000055	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Flavoreductase-like	8087276	3000055	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Flavoreductase-like	8087276	3000055	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Flavoreductase-like	8087276	3000055	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Flavoreductase-like	8087276	3000055	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Flavoreductase-like	8087276	3000055	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	pyranose_ox	e4mihA1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
A	GMC_oxred_N	e4mihA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
B	pyranose_ox	e4mihB2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
B	GMC_oxred_N	e4mihB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
D	pyranose_ox	e4mihD2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
D	GMC_oxred_N	e4mihD1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
F	pyranose_ox	e4mihF2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
F	GMC_oxred_N	e4mihF1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
G	pyranose_ox	e4mihG1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
G	GMC_oxred_N	e4mihG2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
H	pyranose_ox	e4mihH2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
H	GMC_oxred_N	e4mihH1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
C	pyranose_ox	e4mihC1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
C	GMC_oxred_N	e4mihC2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
E	pyranose_ox	e4mihE1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
E	GMC_oxred_N	e4mihE2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF05199	GMC oxidoreductase (GMC_oxred_C)	GMC oxidoreductase	This domain found associated with Pfam:PF00732.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Pyranose 2-oxidase	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors pyranose oxidase activity catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding	-	cellular anatomical structure periplasmic space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR012814	Pyranose 2-oxidase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR007867	Glucose-methanol-choline oxidoreductase, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR051473	Pyranose 2-oxidase-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.