Annotations: 4DK4

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4dk4b_	All alpha proteins	all-alpha NTP pyrophosphatases	all-alpha NTP pyrophosphatases	automated matches	automated matches	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
A	d4dk4a_	All alpha proteins	all-alpha NTP pyrophosphatases	all-alpha NTP pyrophosphatases	automated matches	automated matches	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	dUTPase_2	e4dk4B1	A: alpha bundles	X: all-alpha NTP pyrophosphatases (From Homology)	H: all-alpha NTP pyrophosphatases	T: Type II deoxyuridine triphosphatase-related	F: dUTPase_2	ECOD (1.6)
A	dUTPase_2	e4dk4A1	A: alpha bundles	X: all-alpha NTP pyrophosphatases (From Homology)	H: all-alpha NTP pyrophosphatases	T: Type II deoxyuridine triphosphatase-related	F: dUTPase_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.4010.10	Mainly Alpha	Orthogonal Bundle	all-alpha NTP pyrophosphatase fold	Type II deoxyuridine triphosphatase	CATH (4.3.0)
A	1.10.4010.10	Mainly Alpha	Orthogonal Bundle	all-alpha NTP pyrophosphatase fold	Type II deoxyuridine triphosphatase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08761	dUTPase (dUTPase_2)	dUTPase	2-Deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and pyrophosphate (EC:3.6.1.23). Members of this family have a novel all-alpha fold and are unrelated to the all-beta fold found in dUTPases of the ...	2-Deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and pyrophosphate (EC:3.6.1.23). Members of this family have a novel all-alpha fold and are unrelated to the all-beta fold found in dUTPases of the majority of organisms [1]. This family contains both dUTPase homologues of dUTPase including dCTPase of phage T4.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Deoxyuridine triphosphatase	pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides dUTP diphosphatase activity hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity cation binding ion binding binding metal ion binding small molecule binding	-	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR014871	dUTPase/dCTP pyrophosphatase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.