4CFQ | pdb_00004cfq

Ca-bound truncated (delta13C) and C3S, C81S and C86S mutated S100A4 complexed with non-muscle myosin IIA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4cfqa_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4cfqb_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4cfqc_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d4cfqd_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	S_100	e4cfqA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
B	S_100	e4cfqB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
C	S_100	e4cfqC1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
D	S_100	e4cfqD1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
C	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
D	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01023	S-100/ICaBP type calcium binding domain (S_100)	S-100/ICaBP type calcium binding domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	PROTEIN S100-A4	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding RAGE receptor binding protein binding signaling receptor binding cytoskeletal protein binding actin binding molecular transducer activity molecular function activator activity signaling receptor activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding RAGE receptor binding protein binding signaling receptor binding cytoskeletal protein binding actin binding molecular transducer activity molecular function activator activity signaling receptor activity signaling receptor activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity chemoattractant activity transition metal ion binding calcium-dependent protein binding RNA binding nucleic acid binding identical protein binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction cellular process positive regulation of signaling developmental process cellular developmental process cell differentiation animal organ development anatomical structure development mesenchyme development mesenchymal cell differentiation tissue development epithelial to mesenchymal transition	cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
E [auth Q], F [auth R]	MYOSIN-9	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cytoskeletal motor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cytoskeletal motor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ADP binding cell adhesion molecule binding cadherin binding calmodulin binding identical protein binding virus receptor activity exogenous protein binding protein domain specific binding RNA binding nucleic acid binding integrin binding signaling receptor binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity protein homodimerization activity protein dimerization activity polypeptide conformation or assembly isomerase activity isomerase activity microfilament motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity	membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination cellular process phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination cellular process phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination negative regulation of actin filament severing regulation of biological process regulation of actin filament-based process regulation of cellular process biological regulation negative regulation of biological process actin filament severing regulation of actin filament severing actin filament-based process negative regulation of cellular process biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction endothelial cell migration blood vessel endothelial cell migration cell migration cell motility multicellular organismal process regulation of body fluid levels wound healing response to stimulus homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation cell adhesion cell-cell adhesion response to stress coagulation regulation of biological quality response to wounding platelet activation organelle organization actin cytoskeleton organization cytoskeleton organization developmental process multicellular organism development embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development regulated exocytosis sexual reproduction regulation of reproductive process reproductive process fertilization negative regulation of fertilization secretion by cell cortical granule exocytosis single fertilization calcium-ion regulated exocytosis secretion egg activation export from cell regulation of fertilization exocytosis negative regulation of reproductive process prevention of polyspermy microtubule cytoskeleton organization meiotic cell cycle meiotic spindle organization meiotic cell cycle process microtubule-based process cell cycle spindle organization cell cycle process cellular developmental process myoblast fusion cell-cell fusion muscle cell differentiation myotube differentiation muscle structure development syncytium formation by plasma membrane fusion anatomical structure morphogenesis cell differentiation anatomical structure formation involved in morphogenesis syncytium formation striated muscle cell differentiation myeloid leukocyte differentiation hemopoiesis cell development mononuclear cell differentiation myeloid cell differentiation monocyte differentiation leukocyte differentiation regulation of protein maturation positive regulation of protein maturation positive regulation of protein metabolic process positive regulation of biological process regulation of protein processing in phagocytic vesicle positive regulation of macromolecule biosynthetic process positive regulation of protein processing regulation of primary metabolic process protein maturation positive regulation of metabolic process regulation of proteolysis positive regulation of biosynthetic process proteolysis positive regulation of macromolecule metabolic process positive regulation of protein processing in phagocytic vesicle protein metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process protein processing in phagocytic vesicle regulation of gene expression biosynthetic process positive regulation of gene expression regulation of protein processing positive regulation of proteolysis protein processing metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process actin filament-based movement establishment of organelle localization cellular localization establishment of meiotic spindle localization spindle localization establishment of spindle localization organelle localization establishment of localization in cell blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development tube morphogenesis blood vessel development system development lysosome localization vacuolar localization protein localization establishment of protein localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization formation of primary germ layer embryonic morphogenesis tissue development gastrulation endoderm development endoderm formation endodermal cell differentiation cellular response to stimulus integrin-mediated signaling pathway cell surface receptor signaling pathway signaling cell communication signal transduction actomyosin structure organization cytokinetic process cytokinesis cell division regulation of cellular component organization plasma membrane repair regulation of plasma membrane organization plasma membrane organization regulation of plasma membrane repair endomembrane system organization regulation of developmental process regulation of cell shape cell morphogenesis regulation of cell morphogenesis regulation of anatomical structure morphogenesis plasma membrane bounded cell projection organization cell projection organization uropod organization platelet morphogenesis platelet formation leukocyte migration immune system process establishment of lymphocyte polarity establishment of T cell polarity establishment or maintenance of cell polarity lymphocyte activation leukocyte activation establishment of cell polarity T cell activation membrane protein proteolysis membrane protein ectodomain proteolysis	cellular anatomical structure membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton actomyosin extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle cellular anatomical structure membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton actomyosin extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol contractile ring cell division site cell cortex cortical cytoskeleton actomyosin contractile ring cell periphery cortical actin cytoskeleton cell leading edge cluster of actin-based cell projections brush border cell-cell junction adherens junction anchoring junction cell junction neuromuscular junction synapse protein-containing complex myosin complex myosin II complex ruffle cell projection plasma membrane bounded cell projection actin filament bundle stress fiber contractile actin filament bundle spindle microtubule cytoskeleton focal adhesion cell-substrate junction cell surface intracellular vesicle intracellular membrane-bounded organelle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle cortical granule plasma membrane myosin filament supramolecular fiber supramolecular polymer supramolecular complex cleavage furrow plasma membrane region myosin II filament immunological synapse uropod cell trailing edge nucleus membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, B, C, D	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain	Domain
A, B, C, D	IPR034325	S-100	Domain
A, B, C, D	IPR001751	S100/Calcium binding protein 7/8-like, conserved site	Conserved Site
A, B, C, D	IPR002048	EF-hand domain	Domain
A, B, C, D	IPR011992	EF-hand domain pair	Homologous Superfamily
E [auth Q], F [auth R]	IPR036305	RGS domain superfamily	Homologous Superfamily
E [auth Q], F [auth R]	IPR000048	IQ motif, EF-hand binding site	Binding Site
E [auth Q], F [auth R]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E [auth Q], F [auth R]	IPR004009	Myosin, N-terminal, SH3-like	Domain
E [auth Q], F [auth R]	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
E [auth Q], F [auth R]	IPR001609	Myosin head, motor domain-like	Domain
E [auth Q], F [auth R]	IPR002928	Myosin tail	Domain
E [auth Q], F [auth R]	IPR008989	Myosin S1 fragment, N-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P26447	medulloblastoma malignant colon neoplasm melanotic medulloblastoma intracranial vasospasm adult acute respiratory distress syndrome Neoplasm Invasiveness childhood medulloblastoma keloid adult medulloblastoma medullomyoblastoma with myogenic differentiation head and neck cancer subependymal giant cell astrocytoma limb-girdle muscular dystrophy lung carcinoma malignant ependymoma medulloblastoma malignant colon neoplasm melanotic medulloblastoma intracranial vasospasm adult acute respiratory distress syndrome Neoplasm Invasiveness childhood medulloblastoma keloid adult medulloblastoma medullomyoblastoma with myogenic differentiation head and neck cancer subependymal giant cell astrocytoma limb-girdle muscular dystrophy lung carcinoma malignant ependymoma adrenoleukodystrophy malignant pancreatic neoplasm Alzheimer disease Becker muscular dystrophy nephrosclerosis osteoarthritis susceptibility 1 cystic fibrosis pancreatic ductal adenocarcinoma Duchenne muscular dystrophy pilocytic astrocytoma gastric carcinoma tuberculosis ischemic disease lung adenocarcinoma lymphoplasmacytic lymphoma malignant glioma amyotrophic lateral sclerosis benign colon neoplasm non-small cell lung carcinoma desmoplastic/nodular medulloblastoma pancreatic intraductal papillary-mucinous neoplasm ductal breast carcinoma in situ psoriasis glioblastoma invasive ductal breast carcinoma ulcerative colitis lung cancer malignant mesothelioma atypical teratoid rhabdoid tumor breast fibroadenoma osteoarthritis colonic neoplasm ovarian cancer diabetes mellitus Pick disease Emery-Dreifuss muscular dystrophy
E [auth Q], F [auth R]	Pharos: P35579	macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss Alport syndrome chronic kidney disease nonsyndromic genetic deafness renal hypertension invasive lobular breast carcinoma Neoplasm Invasiveness focal segmental glomerulosclerosis breast carcinoma autosomal dominant nonsyndromic deafness 17 cataract hereditary nephritis acute myeloid leukemia malignant mesothelioma breast cancer macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss Alport syndrome chronic kidney disease nonsyndromic genetic deafness renal hypertension invasive lobular breast carcinoma Neoplasm Invasiveness focal segmental glomerulosclerosis breast carcinoma autosomal dominant nonsyndromic deafness 17 cataract hereditary nephritis acute myeloid leukemia malignant mesothelioma breast cancer osteosarcoma schizophrenia congestive heart failure nodular fasciitis ovarian cancer diabetes mellitus intellectual disability congenital anemia end stage renal failure

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.