Annotations: 4B56

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Phosphodiest_C	e4b56A1	A: a+b two layers	X: Alpha-beta plaits	H: Phosphonoacetate hydrolase insertion domain (From Topology)	T: Phosphonoacetate hydrolase insertion domain	F: Phosphodiest_C	ECOD (1.6)
A	Phosphodiest_N	e4b56A6	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: Phosphodiest_N	ECOD (1.6)
A	Endonuclease_NS	e4b56A4	A: few secondary structure elements	X: His-Me finger endonucleases (From Homology)	H: His-Me finger endonucleases	T: His-Me finger endonucleases	F: Endonuclease_NS	ECOD (1.6)
A	Somatomedin_B	e4b56A3	A: few secondary structure elements	X: Somatomedin B domain (From Topology)	H: Somatomedin B domain (From Topology)	T: Somatomedin B domain	F: Somatomedin_B	ECOD (1.6)
B	UNK_F_TYPE	e4b56B3	A: a+b two layers	X: Alpha-beta plaits	H: Phosphonoacetate hydrolase insertion domain (From Topology)	T: Phosphonoacetate hydrolase insertion domain	F: UNK_F_TYPE	ECOD (1.6)
B	Phosphodiest_N	e4b56B1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: Phosphodiest_N	ECOD (1.6)
B	Endonuclease_NS	e4b56B2	A: few secondary structure elements	X: His-Me finger endonucleases (From Homology)	H: His-Me finger endonucleases	T: His-Me finger endonucleases	F: Endonuclease_NS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	CATH (4.3.0)
A	3.40.570.10	Alpha Beta	3-Layer(aba) Sandwich	Extracellular Endonuclease	Chain A	CATH (4.3.0)
B	3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	CATH (4.3.0)
B	3.30.1360.180	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
B	3.40.570.10	Alpha Beta	3-Layer(aba) Sandwich	Extracellular Endonuclease	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01033	Somatomedin B domain (Somatomedin_B)	Somatomedin B domain	-	Family
A, B	PF01663	Type I phosphodiesterase / nucleotide pyrophosphatase (Phosphodiest)	Type I phosphodiesterase / nucleotide pyrophosphatase	-	Family
A, B	PF01223	DNA/RNA non-specific endonuclease (Endonuclease_NS)	DNA/RNA non-specific endonuclease	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1	binding organic cyclic compound binding nucleic acid binding pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity ATP diphosphatase activity hydrolase activity, acting on acid anhydrides catalytic activity UTP diphosphatase activity cation binding ion binding calcium ion binding binding organic cyclic compound binding nucleic acid binding pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity ATP diphosphatase activity hydrolase activity, acting on acid anhydrides catalytic activity UTP diphosphatase activity cation binding ion binding calcium ion binding metal ion binding small molecule binding dinucleotide phosphatase activity identical protein binding protein binding protein homodimerization activity protein dimerization activity coenzyme A diphosphatase activity GTP diphosphatase activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity cargo receptor activity scavenger receptor activity phosphoric diester hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cyclic-nucleotide phosphodiesterase activity nuclease activity phosphodiesterase I activity exonuclease activity polysaccharide binding carbohydrate binding transition metal ion binding zinc ion binding cyclic-GMP-AMP hydrolase activity	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development heart development circulatory system development ossification bone mineralization developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development heart development circulatory system development ossification bone mineralization biomineral tissue development regulation of body fluid levels secretion by tissue secretion transport biological regulation mucus secretion establishment of localization localization body fluid secretion regulation of biological quality response to stimulus response to endogenous stimulus response to growth factor response to platelet-derived growth factor endochondral ossification replacement ossification endochondral bone morphogenesis anatomical structure morphogenesis skeletal system morphogenesis animal organ morphogenesis bone morphogenesis bone development cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation immune system process cell differentiation T cell differentiation cellular process leukocyte differentiation biological process involved in interspecies interaction between organisms response to other organism defense response defense response to protozoan response to external stimulus response to biotic stimulus response to protozoan defense response to other organism response to stress response to external biotic stimulus ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process nucleobase-containing compound metabolic process glycolytic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process ligamentous ossification inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis cell morphogenesis odontogenesis response to wounding fat cell differentiation mRNA transcription by RNA polymerase II RNA metabolic process nucleobase-containing compound biosynthetic process gene expression mRNA transcription mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process macromolecule metabolic process system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus leukocyte activation involved in inflammatory response inflammatory response adult walking behavior adult locomotory behavior behavior adult behavior locomotory behavior walking behavior cellular response to stimulus cellular response to sodium phosphate cellular response to chemical stimulus response to chemical response to sodium phosphate cellular response to salt response to salt regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling cell communication signal transduction collagen-activated signaling pathway tooth mineralization multicellular organism growth developmental growth growth adipose tissue development fat pad development ear morphogenesis embryonic organ morphogenesis middle ear morphogenesis ear development sensory organ development embryonic morphogenesis embryo development sensory organ morphogenesis embryonic organ development inorganic diphosphate transport inorganic anion transport regulation of developmental process negative regulation of developmental process negative regulation of biological process regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of cellular process negative regulation of cell differentiation regulation of fat cell differentiation cellular homeostasis spinal cord development central nervous system development nervous system development coenzyme A catabolic process cellular catabolic process sulfur compound catabolic process sulfur compound metabolic process amide metabolic process coenzyme A metabolic process magnesium ion homeostasis apoptotic process involved in development apoptotic process cell death programmed cell death muscle cell migration vascular associated smooth muscle cell migration cell migration cell motility smooth muscle cell migration skin development sensory perception of temperature stimulus organ growth bone growth multicellular organismal-level homeostasis inhibition of non-skeletal tissue mineralization anatomical structure homeostasis tissue homeostasis myeloid leukocyte differentiation macrophage differentiation neurogenesis gliogenesis glial cell differentiation myeloid cell differentiation microglia differentiation cellular localization establishment of localization in cell fatty acid metabolic process lipid metabolic process response to nutrient levels response to nutrient response to oxygen-containing compound response to vitamin B6 response to nitrogen compound response to vitamin response to organic cyclic compound neuron apoptotic process blood vessel morphogenesis tube development vasculogenesis vasculature development tube morphogenesis blood vessel development response to hormone response to peptide hormone response to insulin cementum mineralization osteoclast differentiation Wnt signaling pathway D-glucose import hexose transmembrane transport carbohydrate transport transmembrane transport D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport regulation of multicellular organismal process negative regulation of multicellular organismal process regulation of ossification negative regulation of ossification response to bacterium response to Gram-positive bacterium oligodendrocyte apoptotic process glial cell apoptotic process articular cartilage development response to dietary excess energy homeostasis limb development appendage development post-embryonic appendage morphogenesis forelimb morphogenesis post-embryonic limb morphogenesis appendage morphogenesis post-embryonic animal morphogenesis post-embryonic forelimb morphogenesis post-embryonic development limb morphogenesis tissue morphogenesis epithelium development morphogenesis of an epithelium cell population proliferation organic phosphonate metabolic process phosphate ion homeostasis artery development aorta development bone maturation bone mineralization involved in bone maturation developmental maturation anatomical structure maturation ossification involved in bone maturation animal organ maturation muscle cell proliferation smooth muscle cell proliferation vascular associated smooth muscle cell proliferation immune response inflammatory response to antigenic stimulus kidney development renal system development tissue remodeling bone remodeling bone resorption diphosphate metabolic process glucose homeostasis carbohydrate homeostasis muscle cell cellular homeostasis osteoblast differentiation smoothened signaling pathway mature B cell differentiation B cell activation involved in immune response cell activation involved in immune response B cell differentiation leukocyte activation involved in immune response lymphocyte activation involved in immune response mature B cell differentiation involved in immune response B cell activation immune effector process plasma cell differentiation oligodendrocyte development central nervous system myelination glial cell development myelination axon ensheathment in central nervous system oligodendrocyte differentiation axon ensheathment ensheathment of neurons regulation of hormone levels hormone metabolic process bone trabecula formation bone trabecula morphogenesis anatomical structure formation involved in morphogenesis trabecula formation trabecula morphogenesis regulation of signal transduction regulation of primary metabolic process regulation of RNA metabolic process negative regulation of smoothened signaling pathway negative regulation of hh target transcription factor activity regulation of nucleobase-containing compound metabolic process regulation of smoothened signaling pathway regulation of gene expression regulation of molecular function regulation of response to stimulus regulation of DNA-binding transcription factor activity regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of signaling negative regulation of cell communication regulation of RNA biosynthetic process regulation of biosynthetic process regulation of signaling negative regulation of response to stimulus regulation of macromolecule metabolic process negative regulation of signal transduction regulation of cell communication hematopoietic stem cell migration hematopoietic stem cell migration to bone marrow determination of adult lifespan response to fibroblast growth factor cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus fibroblast growth factor receptor signaling pathway cellular response to fibroblast growth factor stimulus enzyme-linked receptor protein signaling pathway fat-soluble vitamin metabolic process organic hydroxy compound metabolic process steroid metabolic process alcohol metabolic process vitamin D3 metabolic process vitamin D metabolic process vitamin metabolic process secondary alcohol metabolic process cell projection organization neuron projection development regeneration response to axon injury neuron projection regeneration cellular component organization axon regeneration neuron differentiation cellular response to stress cellular component organization or biogenesis plasma membrane bounded cell projection organization axon development generation of neurons neuron development glial cell migration microglial cell migration macrophage migration leukocyte migration mononuclear cell migration myeloid leukocyte migration B cell homeostasis leukocyte homeostasis B-1 B cell homeostasis homeostasis of number of cells lymphocyte homeostasis macromolecule modification protein poly-ADP-ribosylation protein metabolic process post-translational protein modification protein modification process organelle organization mitochondrion organization positive regulation of cell communication modulation of chemical synaptic transmission positive regulation of biological process long-term synaptic potentiation synaptic signaling positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling positive regulation of signaling negative regulation of biomineral tissue development regulation of biomineral tissue development regulation of bone mineralization negative regulation of bone mineralization regulation of multicellular organismal development response to metal ion response to magnesium ion	cellular anatomical structure extracellular region extracellular space cell surface cell periphery plasma membrane membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017850	Alkaline-phosphatase-like, core domain superfamily	Homologous Superfamily
A, B	IPR020436	Somatomedin B domain, chordata	Domain
A, B	IPR036024	Somatomedin B-like domain superfamily	Homologous Superfamily
A, B	IPR001212	Somatomedin B domain	Domain
A, B	IPR002591	Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase	Family
A, B	IPR044925	His-Me finger superfamily	Homologous Superfamily
A, B	IPR001604	DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain	Domain
A, B	IPR020821	ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain	Domain
A, B	IPR044929	DNA/RNA non-specific endonuclease superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.