4A3S | pdb_00004a3s

Crystal structure of PFK from Bacillus subtilis

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4a3sa_	Alpha and beta proteins (a/b)	Phosphofructokinase	Phosphofructokinase	Phosphofructokinase	automated matches	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
B	d4a3sb_	Alpha and beta proteins (a/b)	Phosphofructokinase	Phosphofructokinase	Phosphofructokinase	automated matches	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Phosphofructokinase	8069134	4000837	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Phosphofructokinase	8069135	3001648	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Phosphofructokinase	8069135	3001648	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PFK_N	e4a3sA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Phosphofructokinase N-terminal domain	F: PFK_N	ECOD (1.6)
A	PFK_C	e4a3sA2	A: a/b three-layered sandwiches	X: Phosphofructokinase C-terminal domain (From Topology)	H: Phosphofructokinase C-terminal domain (From Topology)	T: Phosphofructokinase C-terminal domain	F: PFK_C	ECOD (1.6)
B	PFK_N	e4a3sB2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Phosphofructokinase N-terminal domain	F: PFK_N	ECOD (1.6)
B	PFK_C	e4a3sB1	A: a/b three-layered sandwiches	X: Phosphofructokinase C-terminal domain (From Topology)	H: Phosphofructokinase C-terminal domain (From Topology)	T: Phosphofructokinase C-terminal domain	F: PFK_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.450	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	3.40.50.460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Phosphofructokinase domain	CATH (4.3.0)
B	3.40.50.450	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.40.50.460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Phosphofructokinase domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00365	Phosphofructokinase (PFK)	Phosphofructokinase		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	6-PHOSPHOFRUCTOKINASE	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding fructose-6-phosphate binding carbohydrate kinase activity kinase activity phosphofructokinase activity 6-phosphofructokinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding metal ion binding	organophosphate metabolic process phosphate-containing compound metabolic process fructose 6-phosphate metabolic process carbohydrate derivative metabolic process metabolic process cellular process phosphorus metabolic process fructose 1,6-bisphosphate metabolic process ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process nucleoside phosphate catabolic process organophosphate metabolic process phosphate-containing compound metabolic process fructose 6-phosphate metabolic process carbohydrate derivative metabolic process metabolic process cellular process phosphorus metabolic process fructose 1,6-bisphosphate metabolic process ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process nucleobase-containing compound metabolic process glycolytic process pyridine-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process glucose catabolic process to pyruvate pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process hexose catabolic process purine nucleoside diphosphate metabolic process primary metabolic process purine-containing compound catabolic process hexose metabolic process nucleotide metabolic process NADH metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process glucose catabolic process nucleoside diphosphate catabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process monosaccharide catabolic process small molecule catabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process monosaccharide metabolic process canonical glycolysis catabolic process ATP metabolic process glycolytic process through glucose-6-phosphate purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy purine-containing compound metabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process glycolytic process through fructose-6-phosphate glucose metabolic process	transferase complex, transferring phosphorus-containing groups protein-containing complex cellular anatomical structure intracellular anatomical structure catalytic complex transferase complex cytoplasm cytosol 6-phosphofructokinase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012828	ATP-dependent 6-phosphofructokinase, prokaryotic	Family
A, B	IPR035966	Phosphofructokinase superfamily	Homologous Superfamily
A, B	IPR000023	Phosphofructokinase domain	Domain
A, B	IPR012003	ATP-dependent 6-phosphofructokinase, prokaryotic-type	Family
A, B	IPR022953	ATP-dependent 6-phosphofructokinase	Family
A, B	IPR015912	Phosphofructokinase, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.