Annotations: 3ZYS

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8058465	3002022	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ras-like P-loop GTPases	8058465	3002022	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Dynamin stalk-like	8054370	3002023	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PH domain-like	8058467	3000134	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PH domain-like	8058467	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Dynamin_N	e3zysA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Dynamin_N	ECOD (1.6)
D	Dynamin_N	e3zysD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Dynamin_N	ECOD (1.6)
B	Dynamin_M	e3zysB2	A: alpha bundles	X: Middle and GTPase effector domains in dynamin-related proteins (From Topology)	H: Middle and GTPase effector domains in dynamin-related proteins (From Topology)	T: Middle and GTPase effector domains in dynamin-related proteins	F: Dynamin_M	ECOD (1.6)
E	Dynamin_M	e3zysE1	A: alpha bundles	X: Middle and GTPase effector domains in dynamin-related proteins (From Topology)	H: Middle and GTPase effector domains in dynamin-related proteins (From Topology)	T: Middle and GTPase effector domains in dynamin-related proteins	F: Dynamin_M	ECOD (1.6)
C	PH	e3zysC1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)
F	PH	e3zysF1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF01031	Dynamin central region (Dynamin_M)	Dynamin central region	-	Family
A, D	PF00350	Dynamin family (Dynamin_N)	Dynamin family		Domain
C, F	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	DYNAMIN-1	pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity RNA binding binding nucleic acid binding guanyl nucleotide binding pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity RNA binding binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding cytoskeletal protein binding microtubule binding protein binding tubulin binding GDP binding identical protein binding protein homodimerization activity protein dimerization activity kinase binding enzyme binding protein kinase binding phosphatidylinositol-3,4,5-trisphosphate binding	localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport membrane organization cellular component organization membrane fission vesicle scission cellular component organization or biogenesis localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport membrane organization cellular component organization membrane fission vesicle scission cellular component organization or biogenesis protein-containing complex organization protein homotetramerization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization establishment of organelle localization vesicle budding from membrane cellular localization synaptic vesicle cycle presynaptic endocytosis vesicle-mediated transport in synapse vesicle organization synaptic vesicle recycling organelle localization establishment of localization in cell synaptic vesicle budding synaptic vesicle localization synaptic vesicle endocytosis vesicle localization establishment of vesicle localization synaptic vesicle budding from presynaptic endocytic zone membrane organelle organization synaptic vesicle transport clathrin coat assembly involved in endocytosis clathrin coat assembly clathrin-dependent endocytosis regulation of cellular component size regulation of vesicle size biological regulation regulation of biological quality regulation of anatomical structure size trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication endosome organization endomembrane system organization	cellular anatomical structure clathrin-coated pit membrane endomembrane system presynaptic endocytic zone synapse plasma membrane presynaptic membrane synaptic membrane cell periphery presynapse presynaptic endocytic zone membrane cell junction plasma membrane region cellular anatomical structure clathrin-coated pit membrane endomembrane system presynaptic endocytic zone synapse plasma membrane presynaptic membrane synaptic membrane cell periphery presynapse presynaptic endocytic zone membrane cell junction plasma membrane region photoreceptor inner segment extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle cytoplasm endocytic vesicle glutamatergic synapse photoreceptor ribbon synapse ribbon synapse cell projection membrane coat protein-containing complex membrane protein complex coated membrane polymeric cytoskeletal fiber intracellular membraneless organelle cytoskeleton membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton chromaffin granule secretory granule secretory vesicle
B, E	INTERFERON-INDUCED GTP-BINDING PROTEIN MX1	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule binding protein binding tubulin binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity identical protein binding	cellular process apoptotic process cell death programmed cell death biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism cellular process apoptotic process cell death programmed cell death biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation signal transduction cell communication response to cytokine response to peptide response to chemical response to type I interferon defense response to virus antiviral innate immune response response to virus cell surface receptor signaling pathway cytokine-mediated signaling pathway cellular response to cytokine stimulus interleukin-27-mediated signaling pathway negative regulation of viral genome replication negative regulation of biological process viral life cycle negative regulation of viral process regulation of viral process regulation of viral life cycle viral genome replication viral process regulation of viral genome replication	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cytosol organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane perinuclear region of cytoplasm polymeric cytoskeletal fiber intracellular membraneless organelle cytoskeleton membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton
C, F	DYNAMIN-1	pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity RNA binding binding nucleic acid binding guanyl nucleotide binding pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity RNA binding binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding cytoskeletal protein binding microtubule binding protein binding tubulin binding GDP binding identical protein binding protein homodimerization activity protein dimerization activity kinase binding enzyme binding protein kinase binding phosphatidylinositol-3,4,5-trisphosphate binding	localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport membrane organization cellular component organization membrane fission vesicle scission cellular component organization or biogenesis localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport membrane organization cellular component organization membrane fission vesicle scission cellular component organization or biogenesis protein-containing complex organization protein homotetramerization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization establishment of organelle localization vesicle budding from membrane cellular localization synaptic vesicle cycle presynaptic endocytosis vesicle-mediated transport in synapse vesicle organization synaptic vesicle recycling organelle localization establishment of localization in cell synaptic vesicle budding synaptic vesicle localization synaptic vesicle endocytosis vesicle localization establishment of vesicle localization synaptic vesicle budding from presynaptic endocytic zone membrane organelle organization synaptic vesicle transport clathrin coat assembly involved in endocytosis clathrin coat assembly clathrin-dependent endocytosis regulation of cellular component size regulation of vesicle size biological regulation regulation of biological quality regulation of anatomical structure size trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication endosome organization endomembrane system organization	cellular anatomical structure clathrin-coated pit membrane endomembrane system presynaptic endocytic zone synapse plasma membrane presynaptic membrane synaptic membrane cell periphery presynapse presynaptic endocytic zone membrane cell junction plasma membrane region cellular anatomical structure clathrin-coated pit membrane endomembrane system presynaptic endocytic zone synapse plasma membrane presynaptic membrane synaptic membrane cell periphery presynapse presynaptic endocytic zone membrane cell junction plasma membrane region photoreceptor inner segment extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle cytoplasm endocytic vesicle glutamatergic synapse photoreceptor ribbon synapse ribbon synapse cell projection membrane coat protein-containing complex membrane protein complex coated membrane polymeric cytoskeletal fiber intracellular membraneless organelle cytoskeleton membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton chromaffin granule secretory granule secretory vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR020850	GTPase effector domain	Domain
A, D	IPR001849	Pleckstrin homology domain	Domain
A, D	IPR001401	Dynamin, GTPase domain	Domain
A, D	IPR045063	Dynamin, N-terminal	Domain
A, D	IPR030381	Dynamin-type guanine nucleotide-binding (G) domain	Domain
A, D	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, D	IPR019762	Dynamin, GTPase region, conserved site	Conserved Site
A, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, D	IPR003130	Dynamin GTPase effector	Domain
A, D	IPR000375	Dynamin stalk domain	Domain
A, D	IPR022812	Dynamin	Family
B, E	IPR020850	GTPase effector domain	Domain
B, E	IPR001401	Dynamin, GTPase domain	Domain
B, E	IPR045063	Dynamin, N-terminal	Domain
B, E	IPR030381	Dynamin-type guanine nucleotide-binding (G) domain	Domain
B, E	IPR019762	Dynamin, GTPase region, conserved site	Conserved Site
B, E	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B, E	IPR003130	Dynamin GTPase effector	Domain
B, E	IPR000375	Dynamin stalk domain	Domain
B, E	IPR022812	Dynamin	Family
C, F	IPR020850	GTPase effector domain	Domain
C, F	IPR001849	Pleckstrin homology domain	Domain
C, F	IPR001401	Dynamin, GTPase domain	Domain
C, F	IPR045063	Dynamin, N-terminal	Domain
C, F	IPR030381	Dynamin-type guanine nucleotide-binding (G) domain	Domain
C, F	IPR011993	PH-like domain superfamily	Homologous Superfamily
C, F	IPR019762	Dynamin, GTPase region, conserved site	Conserved Site
C, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C, F	IPR003130	Dynamin GTPase effector	Domain
C, F	IPR000375	Dynamin stalk domain	Domain
C, F	IPR022812	Dynamin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D	Pharos: Q05193	developmental and epileptic encephalopathy, 31 Lennox-Gastaut syndrome epilepsy medulloblastoma Pick disease psoriasis astrocytic tumor Early infantile epileptic encephalopathy with suppression bursts facioscapulohumeral muscular dystrophy interstitial lung disease malignant glioma pilocytic astrocytoma schizophrenia atypical teratoid rhabdoid tumor dog disease developmental and epileptic encephalopathy, 31 Lennox-Gastaut syndrome epilepsy medulloblastoma Pick disease psoriasis astrocytic tumor Early infantile epileptic encephalopathy with suppression bursts facioscapulohumeral muscular dystrophy interstitial lung disease malignant glioma pilocytic astrocytoma schizophrenia atypical teratoid rhabdoid tumor dog disease glioblastoma invasive ductal breast carcinoma lung carcinoma malignant mesothelioma oligodendroglioma primitive neuroectodermal tumor West syndrome developmental and epileptic encephalopathy ductal breast carcinoma in situ intellectual disability large cell medulloblastoma malignant ependymoma
B, E	Pharos: P20591	acute myeloid leukemia Fanconi anemia influenza juvenile dermatomyositis lung carcinoma malignant pancreatic neoplasm microphthalmia with limb anomalies ovarian cancer plasma cell myeloma atopic eczema Sjogren syndrome breast carcinoma ulcerative colitis cutaneous melanoma Down syndrome acute myeloid leukemia Fanconi anemia influenza juvenile dermatomyositis lung carcinoma malignant pancreatic neoplasm microphthalmia with limb anomalies ovarian cancer plasma cell myeloma atopic eczema Sjogren syndrome breast carcinoma ulcerative colitis cutaneous melanoma Down syndrome gastric neoplasm inherited aplastic anemia large cell medulloblastoma malignant mesothelioma medulloblastoma multiple sclerosis pancreatic ductal adenocarcinoma Acute Myeloid Leukemia (AML-M2) prostate carcinoma avian influenza subependymal giant cell astrocytoma coronary artery disease cystic fibrosis hereditary diffuse gastric adenocarcinoma invasive ductal breast carcinoma lung cancer melanoma myocardial ischemia pancreatic intraductal papillary-mucinous neoplasm psoriasis breast cancer systemic lupus erythematosus cutaneous lupus erythematosus dermatomyositis gastric cancer
C, F	Pharos: Q05193	developmental and epileptic encephalopathy, 31 Lennox-Gastaut syndrome epilepsy medulloblastoma Pick disease psoriasis astrocytic tumor Early infantile epileptic encephalopathy with suppression bursts facioscapulohumeral muscular dystrophy interstitial lung disease malignant glioma pilocytic astrocytoma schizophrenia atypical teratoid rhabdoid tumor dog disease developmental and epileptic encephalopathy, 31 Lennox-Gastaut syndrome epilepsy medulloblastoma Pick disease psoriasis astrocytic tumor Early infantile epileptic encephalopathy with suppression bursts facioscapulohumeral muscular dystrophy interstitial lung disease malignant glioma pilocytic astrocytoma schizophrenia atypical teratoid rhabdoid tumor dog disease glioblastoma invasive ductal breast carcinoma lung carcinoma malignant mesothelioma oligodendroglioma primitive neuroectodermal tumor West syndrome developmental and epileptic encephalopathy ductal breast carcinoma in situ intellectual disability large cell medulloblastoma malignant ependymoma