3TR4

Structure of an inorganic pyrophosphatase (ppa) from Coxiella burnetii

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3tr4a_	All beta proteins	OB-fold	Inorganic pyrophosphatase	automated matches	automated matches	(Coxiella burnetii RSA 493 ) [TaxId: 227377 ],	SCOPe (2.08)
C	d3tr4c_	All beta proteins	OB-fold	Inorganic pyrophosphatase	automated matches	automated matches	(Coxiella burnetii RSA 493 ) [TaxId: 227377 ],	SCOPe (2.08)
D	d3tr4d_	All beta proteins	OB-fold	Inorganic pyrophosphatase	automated matches	automated matches	(Coxiella burnetii RSA 493 ) [TaxId: 227377 ],	SCOPe (2.08)
E	d3tr4e_	All beta proteins	OB-fold	Inorganic pyrophosphatase	automated matches	automated matches	(Coxiella burnetii RSA 493 ) [TaxId: 227377 ],	SCOPe (2.08)
F	d3tr4f_	All beta proteins	OB-fold	Inorganic pyrophosphatase	automated matches	automated matches	(Coxiella burnetii RSA 493 ) [TaxId: 227377 ],	SCOPe (2.08)
B	d3tr4b_	All beta proteins	OB-fold	Inorganic pyrophosphatase	automated matches	automated matches	(Coxiella burnetii RSA 493 ) [TaxId: 227377 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Inorganic pyrophosphatase	8066133	3000589	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Inorganic pyrophosphatase	8066133	3000589	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Inorganic pyrophosphatase	8066133	3000589	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Inorganic pyrophosphatase	8066133	3000589	SCOP2B (2022-06-29)
F	SCOP2 Family	Inorganic pyrophosphatase	8066132	4001947	SCOP2 (2022-06-29)
F	SCOP2 Superfamily	Inorganic pyrophosphatase	8066133	3000589	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Inorganic pyrophosphatase	8066133	3000589	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pyrophosphatase	e3tr4A1	A: beta barrels	X: OB-fold	H: Inorganic pyrophosphatase (From Topology)	T: Inorganic pyrophosphatase	F: Pyrophosphatase	ECOD (1.6)
C	Pyrophosphatase	e3tr4C1	A: beta barrels	X: OB-fold	H: Inorganic pyrophosphatase (From Topology)	T: Inorganic pyrophosphatase	F: Pyrophosphatase	ECOD (1.6)
D	Pyrophosphatase	e3tr4D1	A: beta barrels	X: OB-fold	H: Inorganic pyrophosphatase (From Topology)	T: Inorganic pyrophosphatase	F: Pyrophosphatase	ECOD (1.6)
E	Pyrophosphatase	e3tr4E1	A: beta barrels	X: OB-fold	H: Inorganic pyrophosphatase (From Topology)	T: Inorganic pyrophosphatase	F: Pyrophosphatase	ECOD (1.6)
F	Pyrophosphatase	e3tr4F1	A: beta barrels	X: OB-fold	H: Inorganic pyrophosphatase (From Topology)	T: Inorganic pyrophosphatase	F: Pyrophosphatase	ECOD (1.6)
B	Pyrophosphatase	e3tr4B1	A: beta barrels	X: OB-fold	H: Inorganic pyrophosphatase (From Topology)	T: Inorganic pyrophosphatase	F: Pyrophosphatase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.80.10	Alpha Beta	Alpha-Beta Complex	Inorganic Pyrophosphatase	Inorganic pyrophosphatase	CATH (4.3.0)
C	3.90.80.10	Alpha Beta	Alpha-Beta Complex	Inorganic Pyrophosphatase	Inorganic pyrophosphatase	CATH (4.3.0)
D	3.90.80.10	Alpha Beta	Alpha-Beta Complex	Inorganic Pyrophosphatase	Inorganic pyrophosphatase	CATH (4.3.0)
E	3.90.80.10	Alpha Beta	Alpha-Beta Complex	Inorganic Pyrophosphatase	Inorganic pyrophosphatase	CATH (4.3.0)
F	3.90.80.10	Alpha Beta	Alpha-Beta Complex	Inorganic Pyrophosphatase	Inorganic pyrophosphatase	CATH (4.3.0)
B	3.90.80.10	Alpha Beta	Alpha-Beta Complex	Inorganic Pyrophosphatase	Inorganic pyrophosphatase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00719	Inorganic pyrophosphatase (Pyrophosphatase)	Inorganic pyrophosphatase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Inorganic pyrophosphatase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding pyrophosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity inorganic diphosphate phosphatase activity hydrolase activity, acting on acid anhydrides catalytic activity	phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR036649	Inorganic pyrophosphatase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR008162	Inorganic pyrophosphatase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.