3TF7 | pdb_00003tf7

42F3 QL9/H2-Ld complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth E]	SCOP2B Superfamily	MHC antigen-recognition domain	8034809	3000521	SCOP2B (2022-06-29)
D [auth A]	SCOP2B Superfamily	MHC antigen-recognition domain	8034809	3000521	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth E]	MHC_I	e3tf7E1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
D [auth A]	MHC_I	e3tf7A1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
C	V-set_3	e3tf7C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
C	V-set_4	e3tf7C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
F [auth G]	V-set_3	e3tf7G1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
F [auth G]	V-set_4	e3tf7G2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
G [auth I]	V-set_3	e3tf7I1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
G [auth I]	V-set_4	e3tf7I2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
H [auth K]	V-set_3	e3tf7K5	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
H [auth K]	V-set_4	e3tf7K6	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth E]	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
D [auth A]	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F [auth G]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G [auth I]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
H [auth K]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A [auth E], D [auth A]	MH1 H2-Ld SBM2	G-ALPHA1-ALPHA2	Mus musculus (house mouse)	H2-Ld-2	G-DOMAIN G-ALPHA1, G-DOMAIN G-ALPHA2	MH	(G-ALPHA1-ALPHA2)	IMGT (202510-0)
C, F [auth G], G [auth I], H [auth K]	TR scFv 42F3 Mut7	SCFV-ALPHA-BETA	Mus musculus (house mouse)	TRAV9D-301, TRAJ5801, TRBV13-102, TRBJ2-201	V-DOMAIN V-ALPHA, V-DOMAIN V-BETA	TR	SCFV-ALPHA-BETA	IMGT (202510-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth E], D [auth A]	PF00129	Class I Histocompatibility antigen, domains alpha 1 and 2 (MHC_I)	Class I Histocompatibility antigen, domains alpha 1 and 2		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E], D [auth A]	H2-Ld SBM2	-	response to stimulus immune response immune system process antigen processing and presentation antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of peptide antigen defense response response to stress	membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane lumenal side of endoplasmic reticulum membrane intracellular membrane-bounded organelle endomembrane system side of membrane lumenal side of membrane endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane lumenal side of endoplasmic reticulum membrane intracellular membrane-bounded organelle endomembrane system side of membrane lumenal side of membrane endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane intracellular vesicle phagocytic vesicle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane vesicle endocytic vesicle MHC class I protein complex MHC protein complex cell periphery protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex
B [auth F], E [auth B]	QL9 peptide (QLSPFPFDL)	cation binding vitamin binding thiamine pyrophosphate binding binding ion binding anion binding quaternary ammonium group binding heterocyclic compound binding small molecule binding sulfur compound binding oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors oxoglutarate dehydrogenase (succinyl-transferring) activity cation binding vitamin binding thiamine pyrophosphate binding binding ion binding anion binding quaternary ammonium group binding heterocyclic compound binding small molecule binding sulfur compound binding oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors oxoglutarate dehydrogenase (succinyl-transferring) activity catalytic activity metal ion binding oxoglutarate dehydrogenase (NAD+) activity oxoglutarate dehydrogenase [NAD(P)+] activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	developmental process multicellular organismal process head development animal organ development brain development nervous system development cerebellar cortex development multicellular organism development cerebellum development central nervous system development metencephalon development anatomical structure development hindbrain development system development developmental process multicellular organismal process head development animal organ development brain development nervous system development cerebellar cortex development multicellular organism development cerebellum development central nervous system development metencephalon development anatomical structure development hindbrain development system development forebrain development olfactory lobe development tangential migration from the subventricular zone to the olfactory bulb telencephalon cell migration forebrain cell migration cell migration cellular process telencephalon development cell motility olfactory bulb development pallium development hippocampus development limbic system development pyramidal neuron development cellular developmental process central nervous system neuron development cell development central nervous system neuron differentiation neurogenesis neuron differentiation cell differentiation forebrain generation of neurons generation of neurons forebrain neuron development neuron development forebrain neuron differentiation pyramidal neuron differentiation nucleoside phosphate metabolic process primary metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process acyl-CoA metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process sulfur compound metabolic process small molecule metabolic process succinyl-CoA metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process generation of precursor metabolites and energy diencephalon development thalamus development ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process glycolytic process pyridine-containing compound metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process olfactory bulb mitral cell layer development striatum development subpallium development 2-oxoglutarate metabolic process dicarboxylic acid metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane membrane organelle envelope mitochondrial envelope organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane membrane organelle envelope mitochondrial envelope organelle membrane protein-containing complex oxoglutarate dehydrogenase complex catalytic complex oxidoreductase complex tricarboxylic acid cycle heteromeric enzyme complex alpha-ketoacid dehydrogenase complex nucleus
C, F [auth G], G [auth I], H [auth K]	42F3 Mut7 scFv (42F3 alpha chain, linker, 42F3 beta chain)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth E], D [auth A]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth E], D [auth A]	IPR050208	Antigen-presenting and immune regulatory MHC class I-related	Family
A [auth E], D [auth A]	IPR037055	MHC class I-like antigen recognition-like superfamily	Homologous Superfamily
A [auth E], D [auth A]	IPR003597	Immunoglobulin C1-set	Domain
A [auth E], D [auth A]	IPR010579	MHC class I, alpha chain, C-terminal	Domain
A [auth E], D [auth A]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth E], D [auth A]	IPR011161	MHC class I-like antigen recognition-like	Domain
A [auth E], D [auth A]	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A [auth E], D [auth A]	IPR007110	Immunoglobulin-like domain	Domain
A [auth E], D [auth A]	IPR001039	MHC class I alpha chain, alpha1 alpha2 domains	Domain
A [auth E], D [auth A]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
B [auth F], E [auth B]	IPR042179	Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily	Homologous Superfamily
B [auth F], E [auth B]	IPR005475	Transketolase-like, pyrimidine-binding domain	Domain
B [auth F], E [auth B]	IPR001017	Dehydrogenase, E1 component	Domain
B [auth F], E [auth B]	IPR029061	Thiamin diphosphate-binding fold	Homologous Superfamily
B [auth F], E [auth B]	IPR032106	2-oxoglutarate dehydrogenase E1 component, N-terminal domain	Domain
B [auth F], E [auth B]	IPR011603	2-oxoglutarate dehydrogenase E1 component	Family
B [auth F], E [auth B]	IPR031717	2-oxoglutarate dehydrogenase E1 component/KDG, C-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.