Annotations: 3SP6

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8043779	3001442	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hormone_recep_1	e3sp6A1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	AF-2 domain binding protein binding binding protein domain specific binding transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity RNA binding organic cyclic compound binding nucleic acid binding transcription coactivator activity nuclear receptor coactivator activity transcription factor binding AF-2 domain binding protein binding binding protein domain specific binding transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity RNA binding organic cyclic compound binding nucleic acid binding transcription coactivator activity nuclear receptor coactivator activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear estrogen receptor binding	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of phosphatase activity regulation of catalytic activity positive regulation of biological process positive regulation of phosphate metabolic process positive regulation of molecular function positive regulation of metabolic process regulation of alkaline phosphatase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of phosphatase activity phosphorus metabolic process positive regulation of cellular process positive regulation of phosphorus metabolic process regulation of dephosphorylation positive regulation of dephosphorylation positive regulation of alkaline phosphatase activity dephosphorylation positive regulation of catalytic activity regulation of molecular function positive regulation of hydrolase activity regulation of hydrolase activity regulation of phosphorus metabolic process developmental process multicellular organismal process animal organ development bone trabecula formation anatomical structure morphogenesis multicellular organism development skeletal system development bone trabecula morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis animal organ morphogenesis skeletal system morphogenesis trabecula formation trabecula morphogenesis system development homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process cellular response to stimulus response to stimulus cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress cellular response to chemical stimulus cellular response to stress response to stress response to chemical intracellular receptor signaling pathway response to lipid signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone signal transduction nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound steroid hormone receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus cellular response to organic cyclic compound estrogen receptor signaling pathway cellular response to lipid nuclear receptor-mediated signaling pathway ossification regulation of bone remodeling tissue homeostasis regulation of tissue remodeling regulation of bone resorption bone resorption tissue remodeling bone remodeling anatomical structure homeostasis positive regulation of bone resorption positive regulation of phosphorylation phosphorylation regulation of phosphorylation mitochondrial gene expression mitochondrial transcription mitochondrial RNA metabolic process cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process myeloid leukocyte differentiation regulation of leukocyte differentiation cellular developmental process regulation of developmental process cell development regulation of cell differentiation positive regulation of osteoclast differentiation regulation of cell development positive regulation of developmental process regulation of osteoclast differentiation positive regulation of cell differentiation positive regulation of hemopoiesis cell differentiation osteoclast differentiation regulation of immune system process positive regulation of immune system process regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation leukocyte differentiation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol protein-containing complex nucleus nuclear protein-containing complex mediator complex membrane-enclosed lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol protein-containing complex nucleus nuclear protein-containing complex mediator complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
A	Peroxisome proliferator-activated receptor alpha	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity protein-containing complex binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity phosphatase binding sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity protein-containing complex binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity phosphatase binding protein binding enzyme binding kinase binding mitogen-activated protein kinase kinase kinase binding protein kinase binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein domain specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding NFAT protein binding MDM2/MDM4 family protein binding nuclear steroid receptor activity ubiquitin-like protein conjugating enzyme binding ubiquitin conjugating enzyme binding transcription coregulator binding transcription coactivator binding lipid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development regulation of cellular process oxoacid metabolic process ketone metabolic process regulation of lipid metabolic process positive regulation of biological process organic acid metabolic process developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development regulation of cellular process oxoacid metabolic process ketone metabolic process regulation of lipid metabolic process positive regulation of biological process organic acid metabolic process regulation of primary metabolic process regulation of fatty acid oxidation positive regulation of metabolic process fatty acid oxidation regulation of small molecule metabolic process positive regulation of lipid metabolic process small molecule metabolic process lipid oxidation positive regulation of cellular process positive regulation of fatty acid metabolic process fatty acid metabolic process regulation of biological process biological regulation carboxylic acid metabolic process lipid modification primary metabolic process regulation of ketone metabolic process positive regulation of fatty acid oxidation regulation of fatty acid metabolic process metabolic process cellular process monocarboxylic acid metabolic process positive regulation of small molecule metabolic process regulation of metabolic process lipid metabolic process catabolic process organic acid catabolic process cellular catabolic process positive regulation of fatty acid beta-oxidation monocarboxylic acid catabolic process positive regulation of lipid catabolic process carboxylic acid catabolic process fatty acid beta-oxidation lipid catabolic process regulation of fatty acid beta-oxidation regulation of catabolic process regulation of lipid catabolic process fatty acid catabolic process positive regulation of catabolic process small molecule catabolic process biological process involved in interspecies interaction between organisms transformation of host cell by virus positive regulation of viral process modulation by virus of host process biological process involved in interaction with host biological process involved in symbiotic interaction positive regulation of transformation of host cell by virus regulation of viral process regulation of transformation of host cell by virus symbiont-mediated perturbation of host process viral process modulation of process of another organism regulation of biological process involved in symbiotic interaction modulation by virus of host cellular process regulation of cell adhesion negative regulation of biological process leukocyte cell-cell adhesion negative regulation of cell adhesion cell adhesion cell-cell adhesion negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of cellular process regulation of cell-cell adhesion ribonucleotide catabolic process pyridine nucleotide catabolic process negative regulation of small molecule metabolic process negative regulation of glycolytic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process negative regulation of ATP metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process glycolytic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process negative regulation of metabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process ADP catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process negative regulation of phosphorus metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process negative regulation of hepatocyte apoptotic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death epithelial cell apoptotic process negative regulation of apoptotic process regulation of hepatocyte apoptotic process negative regulation of epithelial cell apoptotic process hepatocyte apoptotic process apoptotic process programmed cell death regulation of biosynthetic process rhythmic process circadian regulation of gene expression circadian rhythm regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to starvation negative regulation of transforming growth factor beta receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus negative regulation of signaling signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction negative regulation of cell communication cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction monosaccharide metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process gluconeogenesis hexose biosynthetic process glucose metabolic process response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus nucleotide biosynthetic process purine ribonucleotide biosynthetic process positive regulation of phosphate metabolic process purine ribonucleoside triphosphate biosynthetic process positive regulation of nucleotide biosynthetic process regulation of nucleotide biosynthetic process ribonucleotide biosynthetic process purine nucleoside triphosphate biosynthetic process positive regulation of purine nucleotide biosynthetic process ribose phosphate biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of phosphorus metabolic process ribonucleoside triphosphate biosynthetic process positive regulation of ATP metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process purine nucleotide biosynthetic process ATP biosynthetic process positive regulation of nucleotide metabolic process positive regulation of biosynthetic process purine-containing compound biosynthetic process carbohydrate derivative biosynthetic process regulation of purine nucleotide biosynthetic process nucleoside triphosphate biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of purine nucleotide metabolic process positive regulation of ATP biosynthetic process regulation of ATP biosynthetic process RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II nucleic acid metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of glucose metabolic process positive regulation of gluconeogenesis positive regulation of glucose metabolic process regulation of gluconeogenesis positive regulation of carbohydrate metabolic process regulation of carbohydrate biosynthetic process regulation of developmental process cellular developmental process negative regulation of developmental process macrophage derived foam cell differentiation regulation of cell differentiation negative regulation of macrophage derived foam cell differentiation foam cell differentiation cell differentiation regulation of macrophage derived foam cell differentiation negative regulation of cell differentiation regulation of response to nutrient levels negative regulation of response to food negative regulation of response to nutrient levels negative regulation of appetite regulation of response to food response to food response to chemical regulation of biological quality regulation of appetite regulation of growth system process negative regulation of muscle hypertrophy regulation of cardiac muscle tissue growth developmental growth regulation of system process negative regulation of muscle cell differentiation muscle cell differentiation regulation of muscle hypertrophy muscle structure development muscle adaptation negative regulation of growth regulation of organ growth regulation of heart growth cardiac muscle tissue growth muscle tissue development cardiac cell development heart growth negative regulation of striated muscle cell differentiation negative regulation of cell growth striated muscle hypertrophy tissue development negative regulation of developmental growth regulation of muscle cell differentiation striated muscle cell differentiation negative regulation of multicellular organismal process regulation of cellular component organization cardiac muscle cell development cell development negative regulation of cell growth involved in cardiac muscle cell development regulation of striated muscle cell differentiation negative regulation of cardiac muscle tissue growth organ growth cell growth striated muscle tissue development cellular component organization negative regulation of organ growth striated muscle cell development muscle cell development cardiac muscle hypertrophy regulation of multicellular organismal process cellular component organization or biogenesis muscle hypertrophy regulation of muscle adaptation regulation of multicellular organismal development regulation of developmental growth negative regulation of heart growth cardiac muscle tissue development developmental cell growth physiological muscle hypertrophy growth cardiac muscle cell differentiation regulation of cell growth involved in cardiac muscle cell development regulation of cell growth regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy cardiocyte differentiation cell growth involved in cardiac muscle cell development physiological cardiac muscle hypertrophy negative regulation of cardiac muscle hypertrophy nitric oxide metabolic process reactive nitrogen species metabolic process enamel mineralization tooth mineralization odontogenesis of dentin-containing tooth odontogenesis amelogenesis anatomical structure morphogenesis anatomical structure formation involved in morphogenesis animal organ morphogenesis biomineral tissue development regulation of circadian rhythm cholesterol storage regulation of localization negative regulation of cholesterol storage lipid storage lipid localization negative regulation of lipid localization maintenance of location localization regulation of lipid storage regulation of lipid localization negative regulation of lipid storage macromolecule localization regulation of cholesterol storage hormone-mediated signaling pathway cellular response to chemical stimulus response to hormone cellular response to hormone stimulus reactive oxygen species biosynthetic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process negative regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species biosynthetic process regulation of reactive oxygen species metabolic process regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response response to external stimulus regulation of inflammatory response negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response epidermis development regulation of signaling receptor activity negative regulation of molecular function regulation of molecular function negative regulation of signaling receptor activity lipid biosynthetic process positive regulation of lipid biosynthetic process regulation of lipid biosynthetic process response to alcohol response to oxygen-containing compound response to ethanol negative regulation of miRNA transcription miRNA transcription regulation of miRNA metabolic process miRNA metabolic process negative regulation of miRNA metabolic process regulation of miRNA transcription sequestering of triglyceride negative regulation of sequestering of triglyceride regulation of sequestering of triglyceride response to peptide hormone response to insulin response to nitrogen compound wound healing response to wounding lipoprotein metabolic process protein metabolic process cellular response to fructose stimulus cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus response to monosaccharide response to carbohydrate cellular response to hexose stimulus cellular response to monosaccharide stimulus response to fructose organic anion transport carboxylic acid transport regulation of transport transport lipid transport regulation of lipid transport regulation of fatty acid transport establishment of localization organic acid transport monocarboxylic acid transport fatty acid transport regulation of organic acid transport behavior adult behavior response to nicotine behavioral response to nicotine response to nutrient circulatory system process regulation of blood pressure negative regulation of blood pressure blood circulation regulation of cytokine production involved in inflammatory response cytokine production regulation of cytokine production negative regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response negative regulation of cytokine production cytokine production involved in inflammatory response negative regulation of gene expression	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR000504	RNA recognition motif domain	Domain
B	IPR034605	PGC-1	Family
B	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
B	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
B	IPR034177	PPARGC1B, RNA recognition motif	Domain
A	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A	IPR003076	Peroxisome proliferator-activated receptor alpha	Family
A	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A	IPR003074	Peroxisome proliferator-activated receptor	Family
A	IPR050234	Nuclear hormone receptor family NR1 subfamily	Family
A	IPR001723	Nuclear hormone receptor	Family
A	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q86YN6	breast carcinoma obesity disorder osteosarcoma primitive neuroectodermal tumor tuberculosis astrocytic tumor glioblastoma large cell medulloblastoma malignant glioma Mammary Neoplasms, Human pancreatic intraductal papillary-mucinous neoplasm psoriasis ulcerative colitis atypical teratoid rhabdoid tumor cutaneous melanoma breast carcinoma obesity disorder osteosarcoma primitive neuroectodermal tumor tuberculosis astrocytic tumor glioblastoma large cell medulloblastoma malignant glioma Mammary Neoplasms, Human pancreatic intraductal papillary-mucinous neoplasm psoriasis ulcerative colitis atypical teratoid rhabdoid tumor cutaneous melanoma hyperlipidemia medulloblastoma oligodendroglioma pituitary cancer skin basal cell carcinoma breast cancer familial hyperlipidemia interstitial cystitis malignant ependymoma monogenic obesity
A	Pharos: Q07869	myopathy hypertriglyceridemia type 2 diabetes mellitus cancer Crohn disease obesity disorder non-alcoholic fatty liver disease hypertensive disorder Hepatomegaly abdominal obesity-metabolic syndrome acute kidney tubular necrosis proteinuria carcinoma chronic kidney disease hypoglycemia myopathy hypertriglyceridemia type 2 diabetes mellitus cancer Crohn disease obesity disorder non-alcoholic fatty liver disease hypertensive disorder Hepatomegaly abdominal obesity-metabolic syndrome acute kidney tubular necrosis proteinuria carcinoma chronic kidney disease hypoglycemia prostate cancer kidney disease sarcomatoid carcinoma liver cancer experimental autoimmune encephalomyelitis familial hyperlipidemia coronary artery disease hyperlipidemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ileocolitis inherited lipid metabolism disorder invasive ductal breast carcinoma alcoholic fatty liver disease ductal breast carcinoma in situ large cell medulloblastoma schizophrenia liver disease attention deficit hyperactivity disorder, inattentive type benign neoplasm maturity-onset diabetes of the young muscular disease hyperlipoproteinemia pancreatic ductal adenocarcinoma hypoalphalipoproteinemia Pick disease inborn carbohydrate metabolic disorder primitive neuroectodermal tumor drug-induced liver injury ischemia reperfusion injury atherosclerosis liver neoplasm atypical teratoid rhabdoid tumor undifferentiated carcinoma mammary neoplasms, animal bipolar disorder medulloblastoma hyperglycemia Crohn's colitis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm dermatitis, atopic plantar fibromatosis atopic eczema malignant ependymoma autism spectrum disorder breast carcinoma fatty liver disease muscle tissue disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.