3SAO

The Siderocalin Ex-FABP functions through dual ligand specificities

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3saob_	All beta proteins	Lipocalins	Lipocalins	Retinol binding protein-like	automated matches	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
A	d3saoa1	All beta proteins	Lipocalins	Lipocalins	Retinol binding protein-like	automated matches	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
A	d3saoa2	Artifacts	Tags	Tags	Tags	C-terminal Tags	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	Retinol binding protein-like	8070905	4002493	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Lipocalins	8070906	3001332	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	Lipocalins	8070906	3001332	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Lipocalin	e3saoB1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin	ECOD (1.6)
A	Lipocalin	e3saoA1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.40.128.20	Mainly Beta	Beta Barrel	Lipocalin	Calycin beta-barrel core domain	CATH (4.3.0)
A	2.40.128.20	Mainly Beta	Beta Barrel	Lipocalin	Calycin beta-barrel core domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00061	Lipocalin / cytosolic fatty-acid binding protein family (Lipocalin)	Lipocalin / cytosolic fatty-acid binding protein family	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid ...	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Extracellular fatty acid-binding protein	fatty acid binding linoleic acid binding organic acid binding binding long-chain fatty acid binding ion binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding stearic acid binding arachidonate binding icosanoid binding fatty acid binding linoleic acid binding organic acid binding binding long-chain fatty acid binding ion binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding stearic acid binding arachidonate binding icosanoid binding icosatetraenoic acid binding oleic acid binding	response to stimulus response to chemical response to xenobiotic stimulus developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular developmental process cell differentiation cellular process response to stimulus response to chemical response to xenobiotic stimulus developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular developmental process cell differentiation cellular process regulation of biological process regulation of cellular process regulation of developmental process biological regulation positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation regulation of myoblast differentiation myoblast differentiation positive regulation of cellular process connective tissue development developmental cell growth developmental growth chondrocyte hypertrophy growth cell development tissue development cell growth skeletal system development chondrocyte differentiation chondrocyte development cartilage development organic anion transport carboxylic acid transport transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport macromolecule localization long-chain fatty acid transport negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death cell population proliferation biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus regulation of cartilage development regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation regulation of multicellular organismal process regulation of multicellular organismal development positive regulation of multicellular organismal process positive regulation of cartilage development response to toxic substance response to peptide response to cytokine defense response to bacterium response to bacterium response to ketone response to lipid response to endogenous stimulus response to alcohol response to glucocorticoid response to oxygen-containing compound response to corticosterone response to mineralocorticoid response to corticosteroid response to hormone response to steroid hormone response to organic cyclic compound positive regulation of cell population proliferation regulation of cell population proliferation cellular response to stimulus response to fatty acid response to linoleic acid cellular response to oxygen-containing compound cellular response to fatty acid cellular response to chemical stimulus cellular response to linoleic acid cellular response to lipid fatty acid homeostasis chemical homeostasis homeostatic process lipid homeostasis regulation of striated muscle cell differentiation muscle cell differentiation myotube differentiation positive regulation of myotube differentiation positive regulation of striated muscle cell differentiation regulation of myotube differentiation positive regulation of muscle cell differentiation regulation of muscle cell differentiation striated muscle cell differentiation acute-phase response inflammatory response acute inflammatory response muscle cell development embryo development ending in birth or egg hatching embryo development response to lipopolysaccharide response to molecule of bacterial origin	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012674	Calycin	Homologous Superfamily
A, B	IPR000566	Lipocalin/cytosolic fatty-acid binding domain	Domain
A, B	IPR022272	Lipocalin family conserved site	Conserved Site
A, B	IPR002345	Lipocalin	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.