3RDV | pdb_00003rdv

Structure of the SLAIN2c-CLIPCG1 complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cap-Gly domain	8039175	3000882	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cap-Gly domain	8039175	3000882	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cap-Gly domain	8039175	3000882	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cap-Gly domain	8039175	3000882	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CAP_GLY	e3rdvA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: CAP_GLY	ECOD (1.6)
B	CAP_GLY	e3rdvB1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: CAP_GLY	ECOD (1.6)
C	CAP_GLY	e3rdvC1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: CAP_GLY	ECOD (1.6)
D	CAP_GLY	e3rdvD1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: CAP_GLY	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.190	Mainly Beta	Roll	SH3 type barrels.	CAP Gly-rich-like domain	CATH (4.3.0)
B	2.30.30.190	Mainly Beta	Roll	SH3 type barrels.	CAP Gly-rich-like domain	CATH (4.3.0)
C	2.30.30.190	Mainly Beta	Roll	SH3 type barrels.	CAP Gly-rich-like domain	CATH (4.3.0)
D	2.30.30.190	Mainly Beta	Roll	SH3 type barrels.	CAP Gly-rich-like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01302	CAP-Gly domain (CAP_GLY)	CAP-Gly domain	Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP ...	Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein Swiss:Q20728 CAP-Gly domain was recently solved [2]. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	CAP-Gly domain-containing linker protein 1	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding microtubule plus-end binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding identical protein binding	cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization microtubule bundle formation positive regulation of organelle organization regulation of cytoskeleton organization cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization microtubule bundle formation positive regulation of organelle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization positive regulation of biological process cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly microtubule polymerization or depolymerization positive regulation of protein polymerization protein-containing complex assembly positive regulation of cellular process protein polymerization regulation of biological process positive regulation of microtubule polymerization or depolymerization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization biological regulation regulation of microtubule-based process microtubule polymerization positive regulation of supramolecular fiber organization regulation of cellular component biogenesis regulation of organelle organization positive regulation of microtubule polymerization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization regulation of microtubule cytoskeleton organization	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane intracellular membraneless organelle chromosome chromosomal region kinetochore membraneless organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome cell periphery cell cortex polymeric cytoskeletal fiber intermediate filament cytoskeleton cytoskeleton intermediate filament supramolecular fiber supramolecular polymer centrosome microtubule organizing center microtubule cytoskeleton ruffle cell projection cell leading edge plasma membrane bounded cell projection cytosol plasma membrane microtubule nucleus
E, F, G, H	SLAIN motif-containing protein 2	-	cellular component organization organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization positive regulation of organelle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization regulation of cellular process cellular component organization organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization positive regulation of organelle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization positive regulation of biological process cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly microtubule polymerization or depolymerization positive regulation of protein polymerization protein-containing complex assembly positive regulation of cellular process protein polymerization regulation of biological process positive regulation of microtubule polymerization or depolymerization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization biological regulation regulation of microtubule-based process microtubule polymerization positive regulation of supramolecular fiber organization regulation of cellular component biogenesis regulation of organelle organization positive regulation of microtubule polymerization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization regulation of microtubule cytoskeleton organization microtubule nucleation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol intracellular organelle centrosome microtubule organizing center cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036859	CAP Gly-rich domain superfamily	Homologous Superfamily
A, B, C, D	IPR032108	CLIP1, zinc knuckle	Domain
A, B, C, D	IPR000938	CAP Gly-rich domain	Domain
E, F, G, H	IPR026179	SLAIN motif-containing protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P30622	spina bifida adenoma esophageal adenocarcinoma hereditary spastic paraplegia malignant ependymoma medulloblastoma periodontitis psoriasis allergic rhinitis gastric carcinoma large cell medulloblastoma malignant glioma osteosarcoma Pick disease rheumatoid arthritis spina bifida adenoma esophageal adenocarcinoma hereditary spastic paraplegia malignant ependymoma medulloblastoma periodontitis psoriasis allergic rhinitis gastric carcinoma large cell medulloblastoma malignant glioma osteosarcoma Pick disease rheumatoid arthritis breast cancer glioblastoma lung cancer Malignant neoplasm of breast ovarian cancer progressive supranuclear palsy
E, F, G, H	Pharos: Q9P270	Crohn disease atypical teratoid rhabdoid tumor large cell medulloblastoma medulloblastoma Sjogren syndrome malignant ependymoma osteosarcoma spina bifida glioblastoma malignant glioma rheumatoid arthritis uterine corpus leiomyoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.