3MDY

Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth C]	d3mdyc_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3mdya_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3mdyd1	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	FKBP immunophilin/proline isomerase	FK-506 binding protein (FKBP12), an immunophilin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3mdyd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth B]	d3mdyb1	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	FKBP immunophilin/proline isomerase	FK-506 binding protein (FKBP12), an immunophilin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth B]	d3mdyb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth C]	SCOP2B Superfamily	Protein kinase-like (PK-like)	8080451	3000066	SCOP2B (2022-06-29)
A	SCOP2 Family	Protein kinases catalytic domain-like	8080450	4003661	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Protein kinase-like (PK-like)	8080451	3000066	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Rotamase-like	8035974	3000622	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Rotamase-like	8035974	3000622	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth C]	Pkinase_Tyr	e3mdyC1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
A	Pkinase_Tyr	e3mdyA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
D	FKBP_C	e3mdyD1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
C [auth B]	FKBP_C	e3mdyB1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth C]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
B [auth C]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
D	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
C [auth B]	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C]	PF07714	Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)	Protein tyrosine and serine/threonine kinase	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [1]; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.	Domain
A, B [auth C]	PF08515	Transforming growth factor beta type I GS-motif (TGF_beta_GS)	Transforming growth factor beta type I GS-motif	-	Family
C [auth B], D	PF00254	FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)	FKBP-type peptidyl-prolyl cis-trans isomerase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C]	Bone morphogenetic protein receptor type-1B	BMP binding protein binding binding cytokine binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding BMP binding protein binding binding cytokine binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding SMAD binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups BMP receptor activity molecular transducer activity signaling receptor activity transmembrane receptor protein serine/threonine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity transforming growth factor beta receptor activity, type I transforming growth factor beta receptor activity cation binding metal ion binding	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process biological regulation negative regulation of biological process negative regulation of chondrocyte proliferation developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process biological regulation negative regulation of biological process negative regulation of chondrocyte proliferation regulation of cell population proliferation negative regulation of cellular process chondrocyte proliferation cellular response to stimulus cellular response to BMP stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus cell surface receptor signaling pathway response to stimulus signaling response to endogenous stimulus cell communication cellular response to endogenous stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway signal transduction response to growth factor BMP signaling pathway enzyme-linked receptor protein signaling pathway connective tissue development animal organ development cell development tissue development multicellular organism development skeletal system development chondrocyte differentiation anatomical structure development chondrocyte development cartilage development system development regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process sensory organ development eye development retina development in camera-type eye visual system development camera-type eye development sensory system development axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cellular component organization or biogenesis plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development retinal ganglion cell axon guidance dorsal/ventral pattern formation pattern specification process regionalization central nervous system neuron differentiation central nervous system development regulation of cartilage development regulation of chondrocyte differentiation regulation of developmental process regulation of cell differentiation positive regulation of chondrocyte differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of multicellular organismal process regulation of multicellular organismal development positive regulation of multicellular organismal process positive regulation of cartilage development regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of biomineral tissue development biomineral tissue development bone mineralization positive regulation of bone mineralization regulation of ossification cell aggregation cartilage condensation skeletal system morphogenesis animal organ morphogenesis positive regulation of cell communication extrinsic apoptotic signaling pathway via death domain receptors positive regulation of signal transduction regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of signaling positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of programmed cell death regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling carbohydrate derivative biosynthetic process proteoglycan biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein metabolic process proteoglycan metabolic process protein phosphorylation phosphorylation macromolecule modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process regulation of osteoblast differentiation positive regulation of osteoblast differentiation defense response response to stress inflammatory response ovulation cycle process sexual reproduction developmental growth reproductive process sex differentiation cellular process involved in reproduction in multicellular organism development of primary female sexual characteristics female gamete generation developmental process involved in reproduction gamete generation ovulation cycle development of primary sexual characteristics ovarian cumulus expansion reproductive structure development ovarian follicle development mammalian oogenesis stage rhythmic process gonad development reproductive system development female gonad development multicellular organismal reproductive process oogenesis growth female sex differentiation fused antrum stage antral ovarian follicle growth germ cell development positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription endochondral bone morphogenesis bone morphogenesis bone development	cell periphery protein-containing complex cellular anatomical structure plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex HFE-transferrin receptor complex receptor complex somatodendritic compartment cell projection dendrite dendritic tree cell periphery protein-containing complex cellular anatomical structure plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex HFE-transferrin receptor complex receptor complex somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cell body neuronal cell body
C [auth B], D	Peptidyl-prolyl cis-trans isomerase FKBP1A	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding FK506 binding amide binding organic cyclic compound binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding FK506 binding amide binding organic cyclic compound binding macrolide binding activin receptor binding receptor serine/threonine kinase binding transmembrane receptor protein serine/threonine kinase binding transmembrane transporter binding SMAD binding I-SMAD binding channel regulator activity molecular function regulator activity transporter regulator activity molecular function inhibitor activity signaling receptor inhibitor activity signaling receptor regulator activity	protein refolding primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process cellular response to stimulus positive regulation of cell communication regulation of cellular process protein refolding primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling activin receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process negative regulation of cell communication negative regulation of activin receptor signaling pathway negative regulation of cellular process enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction transforming growth factor beta receptor superfamily signaling pathway regulation of activin receptor signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway cellular component organization cellular component organization or biogenesis supramolecular fiber organization amyloid fibril formation regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of localization intracellular calcium ion homeostasis calcium ion transport localization monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization regulation of cation channel activity inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of molecular function regulation of transmembrane transport chemical homeostasis cellular localization inorganic ion homeostasis transport homeostatic process monoatomic ion transmembrane transport regulation of transmembrane transporter activity calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport maintenance of location in cell regulation of transporter activity regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion regulation of monoatomic ion transmembrane transporter activity calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion regulation of ryanodine-sensitive calcium-release channel activity cellular homeostasis regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport macromolecule modification peptidyl-amino acid modification peptidyl-proline modification protein modification process protein peptidyl-prolyl isomerization amyloid precursor protein catabolic process regulation of protein metabolic process regulation of amyloid precursor protein catabolic process regulation of macromolecule metabolic process regulation of primary metabolic process amyloid precursor protein metabolic process regulation of metabolic process immune response immune system process regulation of immune response regulation of immune system process developmental process heart development multicellular organismal process cardiac chamber morphogenesis heart trabecula formation animal organ development heart morphogenesis circulatory system development anatomical structure morphogenesis multicellular organism development anatomical structure development anatomical structure formation involved in morphogenesis cardiac chamber development animal organ morphogenesis heart trabecula morphogenesis trabecula formation trabecula morphogenesis system development T cell activation cell activation lymphocyte activation leukocyte activation negative regulation of transforming growth factor beta receptor signaling pathway cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor protein localization regulation of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein maturation by protein folding 'de novo' protein folding system process regulation of system process sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum multicellular organismal movement regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of skeletal muscle contraction by calcium ion signaling release of sequestered calcium ion into cytosol by endoplasmic reticulum skeletal muscle contraction muscle contraction regulation of striated muscle contraction regulation of muscle contraction calcium-mediated signaling striated muscle contraction musculoskeletal movement regulation of skeletal muscle contraction regulation of multicellular organismal process nervous system process neuromuscular process muscle system process regulation of muscle system process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ventricular cardiac muscle tissue morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development muscle tissue development muscle organ development cardiac muscle tissue development tissue development muscle tissue morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis regulation of protein binding positive regulation of molecular function positive regulation of protein binding regulation of binding positive regulation of binding	membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system sarcoplasm intracellular organelle endoplasmic reticulum subcompartment terminal cisterna cellular anatomical structure organelle endoplasmic reticulum sarcoplasmic reticulum cytoplasm membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system sarcoplasm intracellular organelle endoplasmic reticulum subcompartment terminal cisterna cellular anatomical structure organelle endoplasmic reticulum sarcoplasmic reticulum cytoplasm membrane intracellular membraneless organelle Z disc sarcomere I band membraneless organelle contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex bounding membrane of organelle nuclear outer membrane-endoplasmic reticulum membrane network sarcoplasmic reticulum membrane organelle membrane endoplasmic reticulum membrane cytoplasmic side of membrane side of membrane cytosol protein-containing complex membrane protein complex ryanodine receptor complex transporter complex cell periphery endoplasmic reticulum protein-containing complex plasma membrane protein complex voltage-gated calcium channel complex plasma membrane cation channel complex transmembrane transporter complex calcium channel complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C]	IPR000472	Activin types I and II receptor domain	Domain
A, B [auth C]	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B [auth C]	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
A, B [auth C]	IPR000719	Protein kinase domain	Domain
A, B [auth C]	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, B [auth C]	IPR003605	GS domain	Domain
A, B [auth C]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B [auth C]	IPR008271	Serine/threonine-protein kinase, active site	Active Site
A, B [auth C]	IPR000333	Ser/Thr protein kinase, TGFB receptor	Family
C [auth B], D	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
C [auth B], D	IPR050689	FKBP-type Peptidyl-prolyl cis-trans Isomerase	Family
C [auth B], D	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth C]	Pharos: O00238	acromesomelic dysplasia, Demirhan type fibular hypoplasia and complex brachydactyly acromesomelic dysplasia, Grebe type brachydactyly type A1D brachydactyly type A2 prostate cancer Craniofacial Abnormalities head and neck cancer idiopathic pulmonary arterial hypertension large cell medulloblastoma medulloblastoma Alzheimer disease osteogenesis imperfecta brachydactyly peripheral nervous system disease acromesomelic dysplasia, Demirhan type fibular hypoplasia and complex brachydactyly acromesomelic dysplasia, Grebe type brachydactyly type A1D brachydactyly type A2 prostate cancer Craniofacial Abnormalities head and neck cancer idiopathic pulmonary arterial hypertension large cell medulloblastoma medulloblastoma Alzheimer disease osteogenesis imperfecta brachydactyly peripheral nervous system disease brachydactyly type A1A pituitary cancer brachydactyly type C breast carcinoma endometriosis gastric adenocarcinoma heart disease intellectual disability lung carcinoma metastatic melanoma atypical teratoid rhabdoid tumor ovarian cancer peripheral neuropathy polycystic ovary syndrome cystic fibrosis glioblastoma hydrolethalus syndrome invasive ductal breast carcinoma malignant ependymoma acromesomelic dysplasia, Hunter-Thompson type nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia brachydactyly type A1 Pick disease primary pulmonary hypertension breast cancer pulmonary arterial hypertension chronic obstructive pulmonary disease
C [auth B], D	Pharos: P62942	esophageal squamous cell carcinoma Liver Cirrhosis, Experimental medulloblastoma Pick disease renal cell carcinoma astrocytic tumor breast carcinoma lymphangioma malignant mesothelioma osteosarcoma atopic eczema tuberculosis cystic fibrosis glioblastoma kidney angiomyolipoma esophageal squamous cell carcinoma Liver Cirrhosis, Experimental medulloblastoma Pick disease renal cell carcinoma astrocytic tumor breast carcinoma lymphangioma malignant mesothelioma osteosarcoma atopic eczema tuberculosis cystic fibrosis glioblastoma kidney angiomyolipoma lung lymphangioleiomyomatosis mantle cell lymphoma psoriasis tuberous sclerosis bipolar disorder disappearing bone disease malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.