3MDB

Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3mdbb_	All beta proteins	SMAD/FHA domain	SMAD/FHA domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3mdba_	All beta proteins	SMAD/FHA domain	SMAD/FHA domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	SMAD/FHA domain-like	8065246	3000137	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SMAD/FHA domain-like	8065246	3000137	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	FHA	e3mdbB1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: FHA	ECOD (1.6)
A	FHA	e3mdbA1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: FHA	ECOD (1.6)
C	PH	e3mdbC2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)
C	ArfGap	e3mdbC1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: ArfGap	ECOD (1.6)
D	PH	e3mdbD5	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)
D	ArfGap	e3mdbD1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: ArfGap	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.60.200.20	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
A	2.60.200.20	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
C	1.10.220.150	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
C	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
D	1.10.220.150	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
D	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00498	FHA domain (FHA)	FHA domain	-	Family
C, D	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain
C, D	PF01412	Putative GTPase activating protein for Arf (ArfGap)	Putative GTPase activating protein for Arf	Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Kinesin-like protein KIF13B	microtubule motor activity cytoskeletal motor activity ATP-dependent activity protein binding binding 14-3-3 protein binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding microtubule motor activity cytoskeletal motor activity ATP-dependent activity protein binding binding 14-3-3 protein binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule binding tubulin binding kinase binding enzyme binding protein kinase binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis regulation of axonogenesis cell differentiation anatomical structure development cellular component organization or biogenesis regulation of anatomical structure morphogenesis system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cellular process regulation of plasma membrane bounded cell projection organization cellular response to stimulus response to stimulus signaling signal transduction cell communication microtubule-based movement microtubule-based process T cell activation immune system process cell activation lymphocyte activation leukocyte activation localization cellular localization transport establishment of localization in cell cytoskeleton-dependent intracellular transport intracellular transport establishment of localization protein localization establishment of protein localization protein targeting cellular macromolecule localization macromolecule localization	protein-containing complex intracellular anatomical structure intracellular membraneless organelle intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle microtubule associated complex kinesin complex microtubule cytoskeleton cytoplasm axon cell projection protein-containing complex intracellular anatomical structure intracellular membraneless organelle intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle microtubule associated complex kinesin complex microtubule cytoskeleton cytoplasm axon cell projection neuron projection plasma membrane bounded cell projection polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex
C, D	Arf-GAP with dual PH domain-containing protein 1	binding ion binding phosphatidylinositol-3,4,5-trisphosphate binding anion binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding phosphatidylinositol bisphosphate binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity binding ion binding phosphatidylinositol-3,4,5-trisphosphate binding anion binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding phosphatidylinositol bisphosphate binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity alcohol binding inositol 1,3,4,5 tetrakisphosphate binding cation binding metal ion binding	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cellular process signal transduction cell communication positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cellular process signal transduction cell communication positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B	IPR001752	Kinesin motor domain	Domain
A, B	IPR000938	CAP Gly-rich domain	Domain
A, B	IPR032405	Kinesin-associated	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR022164	Kinesin-like	Domain
A, B	IPR036859	CAP Gly-rich domain superfamily	Homologous Superfamily
A, B	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
A, B	IPR000253	Forkhead-associated (FHA) domain	Domain
A, B	IPR022140	Kinesin-like KIF1-type	Domain
A, B	IPR019821	Kinesin motor domain, conserved site	Conserved Site
C, D	IPR001849	Pleckstrin homology domain	Domain
C, D	IPR037849	ADAP, PH domain 1	Domain
C, D	IPR037851	ADAP, PH domain 2	Domain
C, D	IPR037278	ARFGAP/RecO-like zinc finger	Homologous Superfamily
C, D	IPR011993	PH-like domain superfamily	Homologous Superfamily
C, D	IPR052589	Arf-GAP with dual PH domain-containing protein	Family
C, D	IPR001164	Arf GTPase activating protein	Domain
C, D	IPR038508	ArfGAP domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9NQT8	breast cancer malignant ependymoma osteosarcoma prostate carcinoma glioblastoma malignant mesothelioma ovarian cancer interstitial cystitis medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
C, D	Pharos: O75689	atrial fibrillation

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.