Annotations: 3M5L


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad3m5la1 All beta proteins Trypsin-like serine proteases Trypsin-like serine proteases Viral proteases NS3 protease HCV (hepatitis C virus genotype 1a ) [TaxId: 2847144 ], HCV (hepatitis C virus genotype 1a ) [TaxId: 2847144 ], SCOPe (2.08)
Ad3m5la2 Artifacts Tags Tags Tags N-terminal Tags HCV (hepatitis C virus genotype 1a ) [TaxId: 2847144 ], HCV (hepatitis C virus genotype 1a ) [TaxId: 2847144 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APeptidase_S29e3m5lA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: Peptidase_S29ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.40.10.120 Mainly Beta Beta Barrel Thrombin, subunit H CATH (4.3.0)
A2.40.10.10 Mainly Beta Beta Barrel Thrombin, subunit H Trypsin-like serine proteasesCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF02907Hepatitis C virus NS3 protease (Peptidase_S29)Hepatitis C virus NS3 proteaseHepatitis C virus NS3 protein is a serine protease which has a trypsin-like fold. The non-structural (NS) protein NS3 is one of the NS proteins involved in replication of the HCV genome. NS2-3 proteinase, a zinc-dependent enzyme, performs a single p ...Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
NS3/4A

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR002522Hepatitis C virus, Core protein, N-terminalDomain
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
IPR054175NS3 RNA helicase, C-terminal helical domainDomain
IPR038568Hepatitis C virus NS5A, 1B domain superfamilyHomologous Superfamily
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
IPR009003Peptidase S1, PA clanHomologous Superfamily
IPR001650Helicase, C-terminal domain-likeDomain
IPR014001Helicase superfamily 1/2, ATP-binding domainDomain
IPR002868Hepatitis C virus, Non-structural 5a proteinDomain
IPR038170NS5A domain 1a superfamilyHomologous Superfamily
IPR002518Hepatitis C virus, Non-structural protein NS2Domain
IPR013192Hepatitis C virus, Non-structural 5a protein, domain 1aDomain
IPR002521Hepatitis C virus, Core protein, C-terminalDomain
IPR042209Hepatitis C virus non-structural protein NS2, N-terminal domainHomologous Superfamily
IPR000745Hepatitis C virus, Non-structural protein NS4aDomain
IPR011492Non-structural protein NS3-like, DEAD box helicase, flavivirusDomain
IPR042205Hepatitis C virus non-structural protein NS2, C-terminal domainHomologous Superfamily
IPR002166RNA dependent RNA polymerase, hepatitis C virusFamily
IPR002519Hepatitis C virus, Envelope glycoprotein E1Domain
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
IPR044896Hepatitis C virus core protein, chain A superfamilyHomologous Superfamily
IPR024350Hepatitus C virus, Non-structural 5a protein, C-terminalDomain
IPR013193Hepatitis C virus non-structural 5a, 1B domainDomain
IPR004109Hepatitis C virus, NS3 proteaseDomain
IPR049913Hepatitis C virus, p7 channelDomain
IPR002531Hepatitis C virus, Non-structural protein E2/NS1Domain
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
IPR007094RNA-directed RNA polymerase, catalytic domainDomain
IPR001490Hepatitis C virus, Non-structural protein NS4bDomain