3KGR

Crystal structure of the human leukocyte-associated Ig-like receptor-1 (LAIR-1)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8099814	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8099814	3000071	SCOP2B (2022-06-29)
C	SCOP2 Family	I set domains	8099813	4007543	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8099814	3000071	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ig_2	e3kgrA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Ig_2	ECOD (1.6)
B	Ig_2	e3kgrB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Ig_2	ECOD (1.6)
C	Ig_2	e3kgrC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Ig_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, B, C	LAIR1 (leukocyte-associated Ig-like receptor-1)	B2M	Homo sapiens (human)	LAIR1*01	C-LIKE-DOMAIN C-LIKE	RPI	1C-LIKE	IMGT (202448-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF13895	Immunoglobulin domain (Ig_2)	Immunoglobulin domain	This domain contains immunoglobulin-like domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Leukocyte-associated immunoglobulin-like receptor 1	-	response to stimulus immune response immune system process adaptive immune response cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation cell communication immune response-regulating signaling pathway regulation of response to stimulus regulation of immune response cellular process response to stimulus immune response immune system process adaptive immune response cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation cell communication immune response-regulating signaling pathway regulation of response to stimulus regulation of immune response cellular process regulation of immune system process signal transduction	membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane cell periphery plasma membrane specific granule membrane specific granule

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C	IPR003599	Immunoglobulin domain subtype	Domain
A, B, C	IPR050412	Immunoglobulin-like Receptors in Immune Regulation	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q6GTX8	IgA glomerulonephritis astrocytic tumor cutaneous lupus erythematosus lung cancer malignant glioma pilocytic astrocytoma B-cell chronic lymphocytic leukemia glioblastoma interstitial cystitis lung carcinoma non-small cell lung carcinoma subependymal giant cell astrocytoma chronic obstructive pulmonary disease head and neck cancer invasive ductal breast carcinoma IgA glomerulonephritis astrocytic tumor cutaneous lupus erythematosus lung cancer malignant glioma pilocytic astrocytoma B-cell chronic lymphocytic leukemia glioblastoma interstitial cystitis lung carcinoma non-small cell lung carcinoma subependymal giant cell astrocytoma chronic obstructive pulmonary disease head and neck cancer invasive ductal breast carcinoma lymphoplasmacytic lymphoma osteosarcoma tuberculosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.