3HTH

Crystal structure of multidrug binding protein EbrR complexed with proflavin

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TetR_N_2	e3hthA3	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N_2	ECOD (1.6)
A	TetR_C_6_2	e3hthA2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_6_2	ECOD (1.6)
B	TetR_N_2	e3hthB1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N_2	ECOD (1.6)
B	TetR_C_6_2	e3hthB2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_6_2	ECOD (1.6)
C	TetR_N_2	e3hthC1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N_2	ECOD (1.6)
C	TetR_C_6_2	e3hthC2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_6_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.357.10	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
B	1.10.357.10	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
C	1.10.357.10	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00440	Bacterial regulatory proteins, tetR family (TetR_N)	Bacterial regulatory proteins, tetR family	-	Domain
A, B, C	PF17940	Tetracyclin repressor-like, C-terminal domain (TetR_C_31)	Tetracyclin repressor-like, C-terminal domain	This is the C-terminal domain found in putative transcriptional regulator, TetR family proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	EbrA repressor	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription regulator activity DNA-binding transcription factor activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR009057	Homedomain-like superfamily	Homologous Superfamily
A, B, C	IPR050109	HTH-type, TetR-like transcriptional regulator	Family
A, B, C	IPR001647	DNA-binding HTH domain, TetR-type	Domain
A, B, C	IPR041583	Tetracyclin repressor-like, C-terminal, group 31	Domain
A, B, C	IPR036271	Tetracyclin repressor-like, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.