3HQP

Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK) in complex with ATP, Oxalate and fructose 2,6 bisphosphate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3hqpa2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
A	d3hqpa1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
A	d3hqpa3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
B	d3hqpb2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
B	d3hqpb1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
B	d3hqpb3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
C	d3hqpc2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
C	d3hqpc1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
C	d3hqpc3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
D	d3hqpd2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
D	d3hqpd1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
D	d3hqpd3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
E	d3hqpe2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
E	d3hqpe1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
E	d3hqpe3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
F	d3hqpf2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
F	d3hqpf1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
F	d3hqpf3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
G	d3hqpg2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
G	d3hqpg1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
G	d3hqpg3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
H	d3hqph2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
H	d3hqph1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
H	d3hqph3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
I	d3hqpi2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
I	d3hqpi1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
I	d3hqpi3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
J	d3hqpj2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
J	d3hqpj1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
J	d3hqpj3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
K	d3hqpk2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
K	d3hqpk1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
K	d3hqpk3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
L	d3hqpl2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
L	d3hqpl1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
L	d3hqpl3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
M	d3hqpm2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
M	d3hqpm1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
M	d3hqpm3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
N	d3hqpn2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
N	d3hqpn1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
N	d3hqpn3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
O	d3hqpo2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
O	d3hqpo1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
O	d3hqpo3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
P	d3hqpp2	All beta proteins	PK beta-barrel domain-like	PK beta-barrel domain-like	Pyruvate kinase beta-barrel domain	Pyruvate kinase (PK)	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
P	d3hqpp1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Phosphoenolpyruvate/pyruvate domain	Pyruvate kinase	Pyruvate kinase, N-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)
P	d3hqpp3	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	PK C-terminal domain-like	Pyruvate kinase, C-terminal domain	Pyruvate kinase, C-terminal domain	(Leishmania mexicana ) [TaxId: 5665 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PK_2nd	e3hqpA4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
A	PK_1st	e3hqpA2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
A	PK_C	e3hqpA1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
B	PK_2nd	e3hqpB4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
B	PK_1st	e3hqpB2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
B	PK_C	e3hqpB1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
C	PK_2nd	e3hqpC4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
C	PK_1st	e3hqpC2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
C	PK_C	e3hqpC1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
D	PK_2nd	e3hqpD4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
D	PK_1st	e3hqpD2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
D	PK_C	e3hqpD1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
E	PK_2nd	e3hqpE4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
E	PK_1st	e3hqpE2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
E	PK_C	e3hqpE1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
F	PK_2nd	e3hqpF4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
F	PK_1st	e3hqpF2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
F	PK_C	e3hqpF1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
G	PK_2nd	e3hqpG4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
G	PK_1st	e3hqpG2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
G	PK_C	e3hqpG1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
H	PK_2nd	e3hqpH4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
H	PK_1st	e3hqpH2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
H	PK_C	e3hqpH1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
I	PK_2nd	e3hqpI4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
I	PK_1st	e3hqpI2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
I	PK_C	e3hqpI1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
J	PK_2nd	e3hqpJ4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
J	PK_1st	e3hqpJ2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
J	PK_C	e3hqpJ1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
K	PK_2nd	e3hqpK4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
K	PK_1st	e3hqpK2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
K	PK_C	e3hqpK1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
L	PK_2nd	e3hqpL4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
L	PK_1st	e3hqpL2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
L	PK_C	e3hqpL1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
M	PK_2nd	e3hqpM4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
M	PK_1st	e3hqpM2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
M	PK_C	e3hqpM1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
N	PK_2nd	e3hqpN4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
N	PK_1st	e3hqpN2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
N	PK_C	e3hqpN1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
O	PK_2nd	e3hqpO4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
O	PK_1st	e3hqpO2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
O	PK_C	e3hqpO1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
P	PK_2nd	e3hqpP4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
P	PK_1st	e3hqpP2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
P	PK_C	e3hqpP1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
A	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
A	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
B	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
B	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
B	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
C	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
C	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
C	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
D	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
D	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
D	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
E	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
E	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
E	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
F	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
F	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
F	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
G	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
G	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
G	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
H	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
H	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
H	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
I	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
I	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
I	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
J	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
J	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
J	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
K	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
K	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
K	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
L	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
L	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
L	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
M	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
M	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
M	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
N	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
N	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
N	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
O	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
O	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
O	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)
P	3.40.1380.20	Alpha Beta	3-Layer(aba) Sandwich	Pyruvate Kinase	Chain: A, domain 1	CATH (4.3.0)
P	3.20.20.60	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Phosphoenolpyruvate-binding domains	CATH (4.3.0)
P	2.40.33.10	Mainly Beta	Beta Barrel	M1 Pyruvate Kinase	Domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	PF00224	Pyruvate kinase, barrel domain (PK)	Pyruvate kinase, barrel domain	This is the barrel domain of pyruvate kinases. This domain represents the beta/alpha barrel and the small beta-barrel domain inserted within it. The active site is found in a cleft between the two domains [1,2,3,4].	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	PF02887	Pyruvate kinase, alpha/beta domain (PK_C)	Pyruvate kinase, alpha/beta domain	Pyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, ...	Pyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, 3,4]. The protein comprises three-four domains: a small N-terminal helical domain (absent in bacterial PK), a beta/alpha barrel domain, a beta-barrel domain (inserted within the beta/alpha-barrel domain), and a 3-layer alpha/beta/alpha sandwich domain (represented in this entry). This domain is at the C-terminal of pyruvate kinases and contains the FBP (fructose 1,6-bisphosphate) binding site [2,4,5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	Pyruvate kinase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding potassium ion binding alkali metal ion binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups pyruvate kinase activity phosphotransferase activity, alcohol group as acceptor	phosphorylation phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR015795	Pyruvate kinase, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR015813	Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR011037	Pyruvate kinase-like, insert domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR015806	Pyruvate kinase, insert domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR036918	Pyruvate kinase, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR001697	Pyruvate kinase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR018209	Pyruvate kinase, active site	Active Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR040442	Pyruvate kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR015793	Pyruvate kinase, barrel	Domain