Annotations: 3H8Z

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Agenet	e3h8zA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Agenet	ECOD (1.6)
A	Agenet_like	e3h8zA2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Agenet_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.140	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF18336	Fragile X messenger ribonucleoprotein 1, Tudor domain (Tudor_FRX1)	Fragile X messenger ribonucleoprotein 1, Tudor domain	This is the N-terminal Tudor domain (Tud1) found in Fragile X messenger ribonucleoprotein 1 (FMR1) and its paralogues, RNA-binding proteins FXR1/2. The Tud1 domain forms a canonical Tudor barrel [1]. It is usually found in tandem with Agenet domain P ...	This is the N-terminal Tudor domain (Tud1) found in Fragile X messenger ribonucleoprotein 1 (FMR1) and its paralogues, RNA-binding proteins FXR1/2. The Tud1 domain forms a canonical Tudor barrel [1]. It is usually found in tandem with Agenet domain Pfam:PF05641.	Domain
A	PF05641	Agenet domain (Agenet)	Agenet domain	This domain is related to the TUDOR domain Pfam:PF00567 [1]. The function of the agenet domain is unknown. This family now matches both the two Agenet domains in the FMR proteins [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Fragile X mental retardation syndrome-related protein 2	translation regulator activity protein heterodimerization activity protein binding binding protein dimerization activity mRNA 3'-UTR binding RNA binding nucleic acid binding mRNA binding identical protein binding protein homodimerization activity	developmental process animal organ development anatomical structure development regulation of cellular process catabolic process negative regulation of biological process RNA metabolic process macromolecule catabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process regulation of mRNA catabolic process negative regulation of cellular process developmental process animal organ development anatomical structure development regulation of cellular process catabolic process negative regulation of biological process RNA metabolic process macromolecule catabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process regulation of mRNA catabolic process negative regulation of cellular process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound catabolic process regulation of mRNA stability regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of RNA stability nucleic acid catabolic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of mRNA metabolic process regulation of metabolic process RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport modulation of chemical synaptic transmission signaling regulation of translation at synapse, modulating synaptic transmission cell communication synaptic signaling regulation of translation at presynapse, modulating synaptic transmission protein metabolic process trans-synaptic signaling regulation of signaling regulation of translation at presynapse regulation of protein metabolic process cell-cell signaling regulation of translation at synapse translation presynaptic modulation of chemical synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling regulation of translation anterograde trans-synaptic signaling regulation of cell communication positive regulation of protein metabolic process positive regulation of biological process positive regulation of translation positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of gene expression multicellular organismal process head development forebrain development brain development nervous system development dentate gyrus development pallium development multicellular organism development central nervous system development telencephalon development hippocampus development limbic system development system development positive regulation of nervous system development regulation of long-term neuronal synaptic plasticity regulation of developmental process cellular developmental process cell development regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process neurogenesis positive regulation of cell differentiation cell differentiation positive regulation of long-term neuronal synaptic plasticity positive regulation of neurogenesis regulation of multicellular organismal process regulation of neuronal synaptic plasticity regulation of synaptic plasticity regulation of multicellular organismal development positive regulation of cell development positive regulation of multicellular organismal process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process positive regulation of RNA metabolic process mRNA destabilization RNA destabilization positive regulation of catabolic process positive regulation of mRNA catabolic process	intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule membrane cytosol presynapse intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule membrane cytosol presynapse synapse cell junction cell projection neuron projection plasma membrane bounded cell projection postsynapse membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR040148	Fragile X messenger ribonucleoprotein 1	Family
A	IPR008395	Agenet-like domain	Domain
A	IPR047424	RNA-binding protein FXR2, second type I K homology domain	Domain
A	IPR004087	K Homology domain	Domain
A	IPR036612	K Homology domain, type 1 superfamily	Homologous Superfamily
A	IPR040472	Synaptic functional regulator FMRP, KH0 domain	Domain
A	IPR032172	Fragile X-related protein 1, C-terminal region 1	Domain
A	IPR047420	RNA-binding protein FXR2, second Tudor-like Agenet domain	Domain
A	IPR047422	RNA-binding protein FXR2, first type I K homology domain	Domain
A	IPR047421	RNA-binding protein FXR2, first Tudor-like Agenet domain	Domain
A	IPR041560	FMR1, tudor domain	Domain
A	IPR022034	Fragile X messenger ribonucleoprotein 1-like, C-terminal core	Domain
A	IPR004088	K Homology domain, type 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P51116	atrial fibrillation esophageal squamous cell carcinoma IgA glomerulonephritis neuroblastoma uterine corpus leiomyoma brain glioma fragile X syndrome melanoma skin basal cell carcinoma cutaneous melanoma glioblastoma metabolic syndrome X triple-negative breast carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.