Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad3gfta_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd3gftb1 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd3gftb2 Artifacts Tags Tags Tags N-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd3gftd_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd3gftf1 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd3gftf2 Artifacts Tags Tags Tags N-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd3gftc1 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd3gftc2 Artifacts Tags Tags Tags N-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed3gfte1 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed3gfte2 Artifacts Tags Tags Tags N-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRas-like P-loop GTPases 8060856 3002022 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyRas-like P-loop GTPases 8060856 3002022 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyRas-like P-loop GTPases 8060856 3002022 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyRas-like P-loop GTPases 8060856 3002022 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyRas-like P-loop GTPases 8060856 3002022 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyRas-like P-loop GTPases 8060856 3002022 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARase3gftA1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
BRase3gftB1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
DRase3gftD1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
FRase3gftF1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
CRase3gftC1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
ERase3gftE1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00071Ras family (Ras)Ras familyIncludes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
GTPase KRas

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A, B, C, D, E
IPR005225Small GTP-binding domainDomain
A, B, C, D, E
IPR020849Small GTPase, Ras-typeFamily
A, B, C, D, E
IPR001806Small GTPaseFamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B, C, D, E
PharosP01116