3ENP

Crystal structure of human cgi121

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	CGI-121	e3enpB1	A: a+b two layers	X: Alpha-beta plaits	H: PF0523-like (From Topology)	T: PF0523-like	F: CGI-121	ECOD (1.6)
A	CGI-121	e3enpA1	A: a+b two layers	X: Alpha-beta plaits	H: PF0523-like (From Topology)	T: PF0523-like	F: CGI-121	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.2380.10	Alpha Beta	2-Layer Sandwich	PF0523-like	CGI121/TPRKB	CATH (4.3.0)
A	3.30.2380.10	Alpha Beta	2-Layer Sandwich	PF0523-like	CGI121/TPRKB	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08617	Kinase binding protein CGI-121 (CGI-121)	Kinase binding protein CGI-121	CGI-121 has been shown to bind to the p53-related protein kinase (PRPK) [1]. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The K ...	CGI-121 has been shown to bind to the p53-related protein kinase (PRPK) [1]. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation [2]. Interestingly this family also include archaeal homologues, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	TP53RK-binding protein	protein binding binding kinase binding enzyme binding protein kinase binding	tRNA threonylcarbamoyladenosine modification tRNA modification RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA processing tRNA threonylcarbamoyladenosine modification tRNA modification RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA processing macromolecule modification tRNA threonylcarbamoyladenosine metabolic process metabolic process cellular process macromolecule metabolic process RNA processing	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex transferase complex EKC/KEOPS complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036504	CGI121/TPRKB superfamily	Homologous Superfamily
A, B	IPR013926	CGI121/TPRKB	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9Y3C4	Galloway-Mowat syndrome Galloway-Mowat syndrome 5 astrocytic tumor glioblastoma limb-girdle muscular dystrophy medulloblastoma ovarian cancer breast carcinoma Galloway-Mowat syndrome 1 hereditary spastic paraplegia lung cancer microcephaly plasma cell myeloma epilepsy large cell medulloblastoma Galloway-Mowat syndrome Galloway-Mowat syndrome 5 astrocytic tumor glioblastoma limb-girdle muscular dystrophy medulloblastoma ovarian cancer breast carcinoma Galloway-Mowat syndrome 1 hereditary spastic paraplegia lung cancer microcephaly plasma cell myeloma epilepsy large cell medulloblastoma lymphoplasmacytic lymphoma oligodendroglioma primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.