3BCC

STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3bcca1	Alpha and beta proteins (a+b)	LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	MPP-like	Cytochrome bc1 core subunit 1	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d3bccb1	Alpha and beta proteins (a+b)	LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	MPP-like	Cytochrome bc1 core subunit 2	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
C	d3bccc3	Membrane and cell surface proteins and peptides	Heme-binding four-helical bundle	Transmembrane di-heme cytochromes	Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Mitochondrial cytochrome b subunit, N-terminal domain	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
C	d3bccc2	Membrane and cell surface proteins and peptides	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Mitochondrial cytochrome b subunit, C-terminal domain	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
D	d3bccd2	All alpha proteins	Cytochrome c	Cytochrome c	Cytochrome bc1 domain	Cytochrome bc1 domain	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
D	d3bccd3	Membrane and cell surface proteins and peptides	Single transmembrane helix	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
E	d3bcce1	All beta proteins	ISP domain	ISP domain	Rieske iron-sulfur protein (ISP)	ISP subunit of the mitochondrial cytochrome bc1-complex, water-soluble domain	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
E	d3bcce2	Membrane and cell surface proteins and peptides	Single transmembrane helix	ISP transmembrane anchor	ISP transmembrane anchor	Iron-sulfur subunit (ISP) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane region	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
F	d3bccf_	Membrane and cell surface proteins and peptides	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
H	d3bcch_	Membrane and cell surface proteins and peptides	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
J	d3bccj_	Membrane and cell surface proteins and peptides	Single transmembrane helix	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
G	d3bccg_	Membrane and cell surface proteins and peptides	Single transmembrane helix	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038258	3001831	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038259	3001831	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038260	3001831	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038263	3001831	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Transmembrane di-heme cytochromes	8042108	3000517	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8042105	3000966	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cytochrome c	8038266	3000815	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	8038268	3000762	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ISP transmembrane anchor	8038269	3000753	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ISP domain	8038267	3000233	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038272	3000797	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038275	3000806	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8037844	3000779	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038274	3000770	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_M16_C	e3bccA2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
A	Peptidase_M16	e3bccA1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
B	Peptidase_M16_C	e3bccB2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
B	Peptidase_M16	e3bccB1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
C	Cytochrom_B_C	e3bccC1	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: Cytochrom_B_C	ECOD (1.6)
C	Cytochrome_B	e3bccC2	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: Cytochrome_B	ECOD (1.6)
D	Cytochrom_C1_N	e3bccD1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C1_N	ECOD (1.6)
D	Cytochrom_C1_C	e3bccD2	A: extended segments	X: cytochrome c1 transmembrane anchor (From Topology)	H: cytochrome c1 transmembrane anchor (From Topology)	T: cytochrome c1 transmembrane anchor	F: Cytochrom_C1_C	ECOD (1.6)
E	Rieske_cytochrome_bc1,Rieske_6	e3bccE3	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: Rieske_cytochrome_bc1,Rieske_6	ECOD (1.6)
E	UCR_TM	e3bccE2	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: UCR_TM	ECOD (1.6)
F	UCR_14kD	e3bccF1	A: alpha arrays	X: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_14kD	ECOD (1.6)
H	UCR_hinge	e3bccH1	A: alpha bundles	X: cytochrome bc1 complex 11 kDa protein-like	H: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_hinge	ECOD (1.6)
J	UCR_UQCRX_QCR9	e3bccJ1	A: extended segments	X: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_UQCRX_QCR9	ECOD (1.6)
G	UcrQ	e3bccG1	A: extended segments	X: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UcrQ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
B	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
C	1.20.810.10	Mainly Alpha	Up-down Bundle	Cytochrome Bc1 Complex	Chain C	CATH (4.3.0)
D	1.20.5.100	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome c1, transmembrane anchor, C-terminal	CATH (4.3.0)
D	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
E	1.20.5.270	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Ubiquinol cytochrome reductase, transmembrane domain	CATH (4.3.0)
E	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
F	1.10.1090.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain F	CATH (4.3.0)
H	1.10.287.20	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Ubiquinol-cytochrome C reductase hinge domain	CATH (4.3.0)
J	1.20.5.260	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 9	CATH (4.3.0)
G	1.20.5.210	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 8	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
A	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
B	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
B	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
C	PF00032	Cytochrome b(C-terminal)/b6/petD (Cytochrom_B_C)	Cytochrome b(C-terminal)/b6/petD	-	Domain
C	PF00033	Cytochrome b/b6/petB (Cytochrome_B)	Cytochrome b/b6/petB	-	Domain
D	PF02167	Cytochrome C1 family (Cytochrom_C1)	Cytochrome C1 family	-	Family
E	PF02921	Ubiquinol cytochrome reductase transmembrane region (UCR_TM)	Ubiquinol cytochrome reductase transmembrane region	-	Family
E	PF00355	Rieske [2Fe-2S] domain (Rieske)	Rieske [2Fe-2S] domain	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in ...	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein [4].	Domain
H	PF02320	Ubiquinol-cytochrome C reductase hinge protein (UCR_hinge)	Ubiquinol-cytochrome C reductase hinge protein	-	Family
J	PF05365	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like (UCR_UQCRX_QCR9)	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like	-	Family
G	PF02939	UcrQ family (UcrQ)	UcrQ family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	UBIQUINOL CYTOCHROME C OXIDOREDUCTASE	cation binding ion binding binding metal ion binding small molecule binding	-	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane
B	UBIQUINOL CYTOCHROME C OXIDOREDUCTASE	cation binding ion binding binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane
C	UBIQUINOL CYTOCHROME C OXIDOREDUCTASE	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport response to oxidative stress aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport response to oxidative stress response to stimulus response to stress	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex
D	UBIQUINOL CYTOCHROME C OXIDOREDUCTASE	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex
E	UBIQUINOL CYTOCHROME C OXIDOREDUCTASE	oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity transmembrane transporter activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex
F	UBIQUINOL CYTOCHROME C OXIDOREDUCTASE	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex
H	UBIQUINOL CYTOCHROME C OXIDOREDUCTASE	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex
I	UBIQUINOL CYTOCHROME C OXIDOREDUCTASE	-	-	-
J	UBIQUINOL CYTOCHROME C OXIDOREDUCTASE	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex
G	UBIQUINOL CYTOCHROME C OXIDOREDUCTASE	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007863	Peptidase M16, C-terminal	Domain
A	IPR011765	Peptidase M16, N-terminal	Domain
A	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
A	IPR050361	Mitochondrial Processing Peptidase/Ubiquinol-cytochrome c Reductase Complex	Family
B	IPR007863	Peptidase M16, C-terminal	Domain
B	IPR011765	Peptidase M16, N-terminal	Domain
B	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
B	IPR050361	Mitochondrial Processing Peptidase/Ubiquinol-cytochrome c Reductase Complex	Family
B	IPR001431	Peptidase M16, zinc-binding site	Binding Site
C	IPR036150	Cytochrome b/b6, C-terminal domain superfamily	Homologous Superfamily
C	IPR027387	Cytochrome b/b6-like domain superfamily	Homologous Superfamily
C	IPR048260	Cytochrome b/b6, C-terminal domain, eukaryotic/bacterial	Domain
C	IPR016174	Di-haem cytochrome, transmembrane	Homologous Superfamily
C	IPR005798	Cytochrome b/b6, C-terminal	Domain
C	IPR048259	Cytochrome b/b6, N-terminal domain, eukaryotic/bacterial	Domain
C	IPR030689	Cytochrome b	Family
C	IPR005797	Cytochrome b/b6, N-terminal domain	Domain
D	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
D	IPR002326	Cytochrome c1	Family
D	IPR009056	Cytochrome c-like domain	Domain
D	IPR021157	Cytochrome c1, transmembrane anchor, C-terminal	Homologous Superfamily
E	IPR036922	Rieske [2Fe-2S] iron-sulphur domain superfamily	Homologous Superfamily
E	IPR014349	Rieske iron-sulphur protein	Family
E	IPR011070	Globular protein, non-globular alpha/beta subunit	Homologous Superfamily
E	IPR004192	Cytochrome b-c1 complex subunit Rieske, transmembrane domain	Domain
E	IPR015248	Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal	Domain
E	IPR017941	Rieske [2Fe-2S] iron-sulphur domain	Domain
E	IPR005805	Rieske iron-sulphur protein, C-terminal	Domain
E	IPR037008	Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily	Homologous Superfamily
E	IPR006317	Ubiquinol-cytochrome c reductase, iron-sulphur subunit	Domain
F	IPR003197	Cytochrome b-c1 complex subunit 7	Family
F	IPR036544	Cytochrome b-c1 complex subunit 7 superfamily	Homologous Superfamily
H	IPR003422	Cytochrome b-c1 complex, subunit 6	Family
H	IPR023184	Ubiquinol-cytochrome C reductase hinge domain	Domain
H	IPR036811	Ubiquinol-cytochrome C reductase hinge domain superfamily	Homologous Superfamily
J	IPR008027	Cytochrome b-c1 complex subunit 9	Family
J	IPR036656	Cytochrome b-c1 complex subunit 9 superfamily	Homologous Superfamily
G	IPR004205	Cytochrome b-c1 complex subunit 8	Family
G	IPR036642	Cytochrome b-c1 complex subunit 8 superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H, J	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex III (bc1 and b6f) superfamily	Cytochrome bc1 and b6f complexes