2ZBC

Crystal structure of STS042, a stand-alone RAM module protein, from hyperthermophilic archaeon Sulfolobus tokodaii strain7.

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AAsnC_trans_rege2zbcA1 A: a+b two layersX: Alpha-beta plaitsH: Dimeric alpha+beta barrel (From Topology)T: Dimeric alpha+beta barrelF: AsnC_trans_regECOD (1.6)
BAsnC_trans_rege2zbcB1 A: a+b two layersX: Alpha-beta plaitsH: Dimeric alpha+beta barrel (From Topology)T: Dimeric alpha+beta barrelF: AsnC_trans_regECOD (1.6)
DAsnC_trans_rege2zbcD1 A: a+b two layersX: Alpha-beta plaitsH: Dimeric alpha+beta barrel (From Topology)T: Dimeric alpha+beta barrelF: AsnC_trans_regECOD (1.6)
EAsnC_trans_rege2zbcE1 A: a+b two layersX: Alpha-beta plaitsH: Dimeric alpha+beta barrel (From Topology)T: Dimeric alpha+beta barrelF: AsnC_trans_regECOD (1.6)
GAsnC_trans_rege2zbcG1 A: a+b two layersX: Alpha-beta plaitsH: Dimeric alpha+beta barrel (From Topology)T: Dimeric alpha+beta barrelF: AsnC_trans_regECOD (1.6)
HAsnC_trans_rege2zbcH1 A: a+b two layersX: Alpha-beta plaitsH: Dimeric alpha+beta barrel (From Topology)T: Dimeric alpha+beta barrelF: AsnC_trans_regECOD (1.6)
CAsnC_trans_rege2zbcC1 A: a+b two layersX: Alpha-beta plaitsH: Dimeric alpha+beta barrel (From Topology)T: Dimeric alpha+beta barrelF: AsnC_trans_regECOD (1.6)
FAsnC_trans_rege2zbcF1 A: a+b two layersX: Alpha-beta plaitsH: Dimeric alpha+beta barrel (From Topology)T: Dimeric alpha+beta barrelF: AsnC_trans_regECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.70.920 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domainCATH (4.3.0)
B3.30.70.920 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domainCATH (4.3.0)
D3.30.70.920 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domainCATH (4.3.0)
E3.30.70.920 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domainCATH (4.3.0)
G3.30.70.920 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domainCATH (4.3.0)
H3.30.70.920 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domainCATH (4.3.0)
C3.30.70.920 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domainCATH (4.3.0)
F3.30.70.920 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF01037Lrp/AsnC ligand binding domain (AsnC_trans_reg)Lrp/AsnC ligand binding domainThe l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to ...The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold [2]. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Domain

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR019887Transcription regulator AsnC/Lrp, ligand binding domainDomain
A, B, C, D, E
IPR011008Dimeric alpha-beta barrelHomologous Superfamily
A, B, C, D, E
IPR050684HTH-type Transcriptional Regulators and Siroheme DecarboxylasesFamily