2YGU

Crystal structure of fire ant venom allergen, Sol I 2

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Sol_i_2	e2yguA1	A: alpha arrays	X: EF-hand	H: Insect pheromone/odorant-binding proteins (From Topology)	T: Insect pheromone/odorant-binding proteins	F: Sol_i_2	ECOD (1.6)
B	Sol_i_2	e2yguB1	A: alpha arrays	X: EF-hand	H: Insect pheromone/odorant-binding proteins (From Topology)	T: Insect pheromone/odorant-binding proteins	F: Sol_i_2	ECOD (1.6)
D	Sol_i_2	e2yguD1	A: alpha arrays	X: EF-hand	H: Insect pheromone/odorant-binding proteins (From Topology)	T: Insect pheromone/odorant-binding proteins	F: Sol_i_2	ECOD (1.6)
E	Sol_i_2	e2yguE1	A: alpha arrays	X: EF-hand	H: Insect pheromone/odorant-binding proteins (From Topology)	T: Insect pheromone/odorant-binding proteins	F: Sol_i_2	ECOD (1.6)
F	Sol_i_2	e2yguF1	A: alpha arrays	X: EF-hand	H: Insect pheromone/odorant-binding proteins (From Topology)	T: Insect pheromone/odorant-binding proteins	F: Sol_i_2	ECOD (1.6)
G	Sol_i_2	e2yguG1	A: alpha arrays	X: EF-hand	H: Insect pheromone/odorant-binding proteins (From Topology)	T: Insect pheromone/odorant-binding proteins	F: Sol_i_2	ECOD (1.6)
H	Sol_i_2	e2yguH1	A: alpha arrays	X: EF-hand	H: Insect pheromone/odorant-binding proteins (From Topology)	T: Insect pheromone/odorant-binding proteins	F: Sol_i_2	ECOD (1.6)
C	Sol_i_2	e2yguC1	A: alpha arrays	X: EF-hand	H: Insect pheromone/odorant-binding proteins (From Topology)	T: Insect pheromone/odorant-binding proteins	F: Sol_i_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.190	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B	1.10.238.190	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
D	1.10.238.190	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
E	1.10.238.190	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
F	1.10.238.190	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
G	1.10.238.190	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
H	1.10.238.190	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
C	1.10.238.190	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF22750	Ant venom allergen Sol i 2 family (Sol_i_2)	Ant venom allergen Sol i 2 family	Sol i 2, one of four known potent allergens from the venom of red imported fire ant, is a powerful trigger of anaphylaxis. It causes production of IgE antibody in many individuals stung by fire ants. The closest structure homolog of Sol I 2 is the od ...	Sol i 2, one of four known potent allergens from the venom of red imported fire ant, is a powerful trigger of anaphylaxis. It causes production of IgE antibody in many individuals stung by fire ants. The closest structure homolog of Sol I 2 is the odorant binding protein and pheromone binding protein LUSH of the fruit fly Drosophila (Pfam:PF01395), suggesting a possible similar biological function [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	VENOM ALLERGEN 2	-	-	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR038211	Ant venom allergen, Sol i 2/4 superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR055216	Ant venom allergen Sol i 2/4	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR020181	Ant venom allergen, Sol i 2	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.