2XCM

COMPLEX OF HSP90 N-TERMINAL, SGT1 CS AND RAR1 CHORD2 DOMAIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2xcma1	Alpha and beta proteins (a+b)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Heat shock protein 90, HSP90, N-terminal domain	automated matches	(Hordeum vulgare ) [TaxId: 4513 ],	SCOPe (2.08)
A	d2xcma2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Hordeum vulgare ) [TaxId: 4513 ],	SCOPe (2.08)
B	d2xcmb1	Alpha and beta proteins (a+b)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Heat shock protein 90, HSP90, N-terminal domain	automated matches	(Hordeum vulgare ) [TaxId: 4513 ],	SCOPe (2.08)
B	d2xcmb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Hordeum vulgare ) [TaxId: 4513 ],	SCOPe (2.08)
D	d2xcmd_	All beta proteins	HSP20-like chaperones	HSP20-like chaperones	automated matches	automated matches	THALE CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
C	d2xcmc_	All beta proteins	HSP20-like chaperones	HSP20-like chaperones	automated matches	automated matches	THALE CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GHKL (Gyrase, Hsp90, Histidine Kinase, MutL) domain-like	8070948	3000091	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GHKL (Gyrase, Hsp90, Histidine Kinase, MutL) domain-like	8070948	3000091	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Hsp20 chaperone-like	8068204	3001242	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Hsp20 chaperone-like	8068204	3001242	SCOP2B (2022-06-29)
E	SCOP2 Family	CHORD domain-like	8046776	4005295	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	CHORD domain-like	8103639	3002798	SCOP2 (2022-06-29)
F	SCOP2B Superfamily	CHORD domain-like	8103639	3002798	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HATPase_c	e2xcmA1	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: HATPase_c	ECOD (1.6)
B	HATPase_c	e2xcmB1	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: HATPase_c	ECOD (1.6)
D	CS	e2xcmD1	A: beta sandwiches	X: HSP20-like	H: HSP20-like chaperones (From Topology)	T: HSP20-like chaperones	F: CS	ECOD (1.6)
C	CS	e2xcmC1	A: beta sandwiches	X: HSP20-like	H: HSP20-like chaperones (From Topology)	T: HSP20-like chaperones	F: CS	ECOD (1.6)
E	CHORD	e2xcmE1	A: few secondary structure elements	X: Btk/CHORD zinc fingers (From Topology)	H: Btk/CHORD zinc fingers (From Topology)	T: Btk/CHORD zinc fingers	F: CHORD	ECOD (1.6)
F	CHORD	e2xcmF1	A: few secondary structure elements	X: Btk/CHORD zinc fingers (From Topology)	H: Btk/CHORD zinc fingers (From Topology)	T: Btk/CHORD zinc fingers	F: CHORD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)
B	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)
D	2.60.40.790	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
C	2.60.40.790	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13589	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	Domain
C, D	PF04969	CS domain (CS)	CS domain	The CS and CHORD (Pfam:PF04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD [1]. It has been suggested that the CS domain ...	The CS and CHORD (Pfam:PF04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD [1]. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies [2]. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19) (Swiss:O94966), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2 [3].	Domain
E, F	PF04968	CHORD (CHORD)	CHORD	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CYTOSOLIC HEAT SHOCK PROTEIN 90	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding unfolded protein binding protein binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent protein folding chaperone protein folding chaperone cation binding metal ion binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular response to stimulus cellular response to heat response to stimulus cellular response to stress response to stress response to heat response to abiotic stimulus cellular process response to temperature stimulus	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm cell periphery plasma membrane membrane protein-containing complex
C, D	SGT1-LIKE PROTEIN	protein binding binding protein-folding chaperone binding	catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process developmental process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process developmental process multicellular organismal process reproductive system development reproductive process embryo development developmental process involved in reproduction multicellular organism development fruit development embryo development ending in seed dormancy seed development anatomical structure development reproductive structure development post-embryonic development system development cellular response to stimulus response to stimulus response to endogenous stimulus cellular response to auxin stimulus response to auxin cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to hormone stimulus response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to stress response to hypoxia response to stress response to oxygen levels response to abiotic stimulus biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus regulation of defense response regulation of response to biotic stimulus regulation of biological process regulation of response to external stimulus biological regulation defense response to fungus regulation of defense response to fungus regulation of response to stimulus regulation of response to stress response to fungus	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex SCF ubiquitin ligase complex transferase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex SCF ubiquitin ligase complex transferase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
E, F	RAR1	Hsp90 protein binding protein binding binding heat shock protein binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization respiratory burst respiratory burst involved in defense response response to stimulus defense response immune system process response to stress metabolic process cellular process immune effector process biological process involved in interspecies interaction between organisms regulation of protein stability biological regulation regulation of biological quality protein stabilization respiratory burst respiratory burst involved in defense response response to stimulus defense response immune system process response to stress metabolic process cellular process immune effector process biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus defense response to fungus response to fungus cellular response to stimulus immune response defense response to symbiont cell death symbiont-induced defense-related programmed cell death cellular response to stress plant-type hypersensitive response innate immune response programmed cell death	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR020575	Heat shock protein Hsp90, N-terminal	Domain
A, B	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B	IPR037196	HSP90, C-terminal domain	Homologous Superfamily
A, B	IPR003594	Histidine kinase/HSP90-like ATPase domain	Domain
A, B	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
A, B	IPR001404	Heat shock protein Hsp90 family	Family
A, B	IPR019805	Heat shock protein Hsp90, conserved site	Conserved Site
C, D	IPR007699	SGS domain	Domain
C, D	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
C, D	IPR007052	CS domain	Domain
C, D	IPR019734	Tetratricopeptide repeat	Repeat
C, D	IPR008978	HSP20-like chaperone	Homologous Superfamily
C, D	IPR044563	Protein Sgt1-like	Family
E, F	IPR043316	Cysteine and histidine-rich domain-containing protein RAR1	Family
E, F	IPR007051	CHORD domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.