2XAL

Lead derivative of Inositol 1,3,4,5,6-pentakisphosphate 2-kinase from A. thaliana in complex with ADP and IP6.

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Ins_P5_2-kin	e2xalB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: SAICAR synthase	F: Ins_P5_2-kin	ECOD (1.6)
A	Ins_P5_2-kin	e2xalA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: SAICAR synthase	F: Ins_P5_2-kin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.200.110	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	3.30.200.110	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF06090	Inositol-pentakisphosphate 2-kinase (Ins_P5_2-kin)	Inositol-pentakisphosphate 2-kinase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	INOSITOL-PENTAKISPHOSPHATE 2-KINASE	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity inositol pentakisphosphate kinase activity kinase activity transferase activity inositol phosphate kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups inositol-1,3,4,6-tetrakisphosphate 2-kinase activity inositol tetrakisphosphate kinase activity inositol-1,4,5,6-tetrakisphosphate 2-kinase activity cation binding metal ion binding	phosphate ion homeostasis intracellular phosphate ion homeostasis cellular homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process intracellular chemical homeostasis biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to fungus phosphate ion homeostasis intracellular phosphate ion homeostasis cellular homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process intracellular chemical homeostasis biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to fungus defense response to other organism response to stress response to external biotic stimulus response to fungus polyol metabolic process small molecule biosynthetic process organic hydroxy compound metabolic process myo-inositol hexakisphosphate metabolic process alcohol metabolic process inositol phosphate metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process inositol phosphate biosynthetic process organic hydroxy compound biosynthetic process myo-inositol hexakisphosphate biosynthetic process phosphate-containing compound metabolic process polyol biosynthetic process alcohol biosynthetic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process phosphorylation defense response to symbiont defense response to virus response to virus defense response to bacterium response to bacterium developmental process multicellular organismal process plant organ development post-embryonic root development multicellular organism development lateral root development anatomical structure development post-embryonic plant organ development post-embryonic development root development system development root system development	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR043001	Inositol-pentakisphosphate 2-kinase, N-terminal lobe	Homologous Superfamily
A, B	IPR009286	Inositol-pentakisphosphate 2-kinase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.