2HNU | pdb_00002hnu

Crystal Structure of a Dipeptide Complex of Bovine Neurophysin-I

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2hnua_	All beta proteins	Neurophysin II	Neurophysin II	Neurophysin II	Neurophysin II	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d2hnub_	All beta proteins	Neurophysin II	Neurophysin II	Neurophysin II	Neurophysin II	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d2hnuc_	All beta proteins	Neurophysin II	Neurophysin II	Neurophysin II	Neurophysin II	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d2hnud_	All beta proteins	Neurophysin II	Neurophysin II	Neurophysin II	Neurophysin II	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
E	d2hnue_	All beta proteins	Neurophysin II	Neurophysin II	Neurophysin II	Neurophysin II	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Neurophysin II	8070325	3001022	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Neurophysin II	8070325	3001022	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Neurophysin II	8070325	3001022	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Neurophysin II	8070325	3001022	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Neurophysin II	8070325	3001022	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hormone_5	e2hnuA1	A: beta sandwiches	X: Neurophysin II (From Topology)	H: Neurophysin II (From Topology)	T: Neurophysin II	F: Hormone_5	ECOD (1.6)
B	Hormone_5	e2hnuB1	A: beta sandwiches	X: Neurophysin II (From Topology)	H: Neurophysin II (From Topology)	T: Neurophysin II	F: Hormone_5	ECOD (1.6)
C	Hormone_5	e2hnuC1	A: beta sandwiches	X: Neurophysin II (From Topology)	H: Neurophysin II (From Topology)	T: Neurophysin II	F: Hormone_5	ECOD (1.6)
D	Hormone_5	e2hnuD1	A: beta sandwiches	X: Neurophysin II (From Topology)	H: Neurophysin II (From Topology)	T: Neurophysin II	F: Hormone_5	ECOD (1.6)
E	Hormone_5	e2hnuE1	A: beta sandwiches	X: Neurophysin II (From Topology)	H: Neurophysin II (From Topology)	T: Neurophysin II	F: Hormone_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.9.10	Mainly Beta	Sandwich	Neurophysin II	Chain A	CATH (4.3.0)
B	2.60.9.10	Mainly Beta	Sandwich	Neurophysin II	Chain A	CATH (4.3.0)
C	2.60.9.10	Mainly Beta	Sandwich	Neurophysin II	Chain A	CATH (4.3.0)
D	2.60.9.10	Mainly Beta	Sandwich	Neurophysin II	Chain A	CATH (4.3.0)
E	2.60.9.10	Mainly Beta	Sandwich	Neurophysin II	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF00184	Neurohypophysial hormones, C-terminal Domain (Hormone_5)	Neurohypophysial hormones, C-terminal Domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Oxytocin-neurophysin 1	molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity neuropeptide activity signaling receptor activator activity hormone activity protein binding molecular function regulator activity neuropeptide hormone activity signaling receptor regulator activity receptor ligand activity neurohypophyseal hormone activity molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity neuropeptide activity signaling receptor activator activity hormone activity protein binding molecular function regulator activity neuropeptide hormone activity signaling receptor regulator activity receptor ligand activity neurohypophyseal hormone activity vasopressin receptor binding V1A vasopressin receptor binding G protein-coupled receptor binding oxytocin receptor binding	multicellular organismal process regulation of biological process regulation of cellular process homeostatic process biological regulation positive regulation of biological process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process multicellular organismal process regulation of biological process regulation of cellular process homeostatic process biological regulation positive regulation of biological process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process cellular process metabolic process regulation of multicellular organismal process regulation of metabolic process positive regulation of cellular process response to stimulus response to hormone response to endogenous stimulus response to chemical response to estrogen	membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle extracellular region membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR022423	Neurohypophysial hormone, conserved site	Conserved Site
A, B, C, D, E	IPR036387	Neurohypophysial hormone domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR000981	Neurohypophysial hormone	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.