2G35

NMR structure of talin-PTB in complex with PIPKI

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2g35a1	All beta proteins	PH domain-like barrel	PH domain-like	Third domain of FERM	Talin	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PH domain-like	8044255	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IRS_1	e2g35A1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: IRS_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02174	PTB domain (IRS-1 type) (IRS)	PTB domain (IRS-1 type)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Talin-1	binding phospholipid binding lipid binding phosphatidylinositol binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding LIM domain binding protein domain specific binding vinculin binding cell adhesion molecule binding integrin binding binding phospholipid binding lipid binding phosphatidylinositol binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding LIM domain binding protein domain specific binding vinculin binding cell adhesion molecule binding integrin binding signaling receptor binding structural constituent of cytoskeleton structural molecule activity modified amino acid binding phosphatidylserine binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process integrin activation cellular component organization or biogenesis cortical cytoskeleton organization microtubule cytoskeleton organization cytoplasmic microtubule organization cortical microtubule organization organelle organization microtubule-based process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process integrin activation cellular component organization or biogenesis cortical cytoskeleton organization microtubule cytoskeleton organization cytoplasmic microtubule organization cortical microtubule organization organelle organization microtubule-based process supramolecular fiber organization cytoskeleton organization cellular response to stimulus regulation of biological process integrin-mediated signaling pathway regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell communication signal transduction cell junction organization cell junction assembly cell-substrate junction assembly cell-substrate junction organization actin cytoskeleton organization cortical actin cytoskeleton organization actin filament-based process cell adhesion	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane cell surface intracellular anatomical structure cytoplasm cell-cell junction adherens junction intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle
B	peptide	phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups 1-phosphatidylinositol-4-phosphate 5-kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups 1-phosphatidylinositol-4-phosphate 5-kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis phagocytosis phosphatidylinositol metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process cell chemotaxis cellular response to stimulus chemotaxis response to stimulus neutrophil chemotaxis response to external stimulus neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis immune system process granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization clathrin-dependent endocytosis receptor-mediated endocytosis membrane organization cell adhesion cell-cell adhesion regulated exocytosis signaling synaptic vesicle exocytosis cell communication synaptic signaling secretion by cell signal release trans-synaptic signaling regulation of biological process neurotransmitter secretion secretion biological regulation cell-cell signaling export from cell neurotransmitter transport chemical synaptic transmission signal release from synapse exocytosis anterograde trans-synaptic signaling regulation of signaling regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cellular process regulation of signal transduction intracellular signal transduction regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction adherens junction organization adherens junction assembly cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cell-cell junction assembly cell-cell junction organization	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane intracellular anatomical structure cytoplasm cytosol presynapse synapse membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cell-cell junction adherens junction uropod cell trailing edge endosome membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle vesicle organelle membrane phagocytic cup

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000299	FERM domain	Domain
A	IPR002404	IRS-type PTB domain	Domain
A	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A	IPR019748	FERM central domain	Domain
A	IPR015009	Vinculin-binding site-containing domain	Domain
A	IPR032425	Talin, N-terminal F0 domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR035964	I/LWEQ domain superfamily	Homologous Superfamily
A	IPR015224	Talin, central	Domain
A	IPR054082	Talin, IBS2B domain	Domain
A	IPR019749	Band 4.1 domain	Domain
A	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A	IPR036476	Talin, central domain superfamily	Homologous Superfamily
A	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
A	IPR002558	I/LWEQ domain	Domain
A	IPR019747	FERM conserved site	Conserved Site
A	IPR054060	Talin 1-like, rod-segment domain	Domain
A	IPR049108	Talin, R4 domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR037438	Talin-1/2, rod-segment	Domain
B	IPR027483	Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily	Homologous Superfamily
B	IPR002498	Phosphatidylinositol-4-phosphate 4/5-kinase, core	Domain
B	IPR027484	Phosphatidylinositol-4-phosphate 5-kinase, N-terminal	Homologous Superfamily
B	IPR023610	Phosphatidylinositol-4/5-phosphate 5/4-kinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: O60331	lethal congenital contracture syndrome 3 arthrogryposis glioblastoma medulloblastoma atypical teratoid rhabdoid tumor osteosarcoma cutaneous melanoma malignant ependymoma psoriasis