2AAL | pdb_00002aal

Crystal Structures of the Wild-type, Mutant-P1A and Inactivated Malonate Semialdehyde Decarboxylase: A Structural Basis for the Decarboxylase and Hydratase Activities

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2aala1	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MSAD-like	Malonate semialdehyde decarboxylase, MSAD	(Pseudomonas pavonaceae ) [TaxId: 47881 ],	SCOPe (2.08)
B	d2aalb2	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MSAD-like	Malonate semialdehyde decarboxylase, MSAD	(Pseudomonas pavonaceae ) [TaxId: 47881 ],	SCOPe (2.08)
B	d2aalb3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Pseudomonas pavonaceae ) [TaxId: 47881 ],	SCOPe (2.08)
C	d2aalc_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MSAD-like	Malonate semialdehyde decarboxylase, MSAD	(Pseudomonas pavonaceae ) [TaxId: 47881 ],	SCOPe (2.08)
D	d2aald_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MSAD-like	Malonate semialdehyde decarboxylase, MSAD	(Pseudomonas pavonaceae ) [TaxId: 47881 ],	SCOPe (2.08)
E	d2aale_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MSAD-like	Malonate semialdehyde decarboxylase, MSAD	(Pseudomonas pavonaceae ) [TaxId: 47881 ],	SCOPe (2.08)
F	d2aalf_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MSAD-like	Malonate semialdehyde decarboxylase, MSAD	(Pseudomonas pavonaceae ) [TaxId: 47881 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	MSAD-like	8024430	4003828	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Tautomerase/MIF	8036809	3001770	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Tautomerase/MIF	8036809	3001770	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Tautomerase/MIF	8036809	3001770	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Tautomerase/MIF	8036809	3001770	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Tautomerase/MIF	8036809	3001770	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Tautomerase/MIF	8036809	3001770	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Tautomerase_2	e2aalA1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
B	Tautomerase_2	e2aalB1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
C	Tautomerase_2	e2aalC1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
D	Tautomerase_2	e2aalD1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
E	Tautomerase_2	e2aalE1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
F	Tautomerase_2	e2aalF1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
B	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
C	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
D	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
E	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
F	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF14552	Tautomerase enzyme (Tautomerase_2)	Tautomerase enzyme		Domain

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR037479	Tautomerase, MSAD family	Family
A, B, C, D, E A, B, C, D, E, F	IPR014347	Tautomerase/MIF superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.