2X1H

Crystal structure of the human MGC45594 gene product in complex with raloxifene

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ADH_N	e2x1hA1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
A	ADH_zinc_N	e2x1hA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
B	ADH_N	e2x1hB1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
B	ADH_zinc_N	e2x1hB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00107	Zinc-binding dehydrogenase (ADH_zinc_N)	Zinc-binding dehydrogenase	-	Domain
A, B	PF08240	Alcohol dehydrogenase GroES-like domain (ADH_N)	Alcohol dehydrogenase GroES-like domain	This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure [1-2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2	oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	developmental process fat cell differentiation regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of developmental process biological regulation negative regulation of biological process regulation of cell differentiation negative regulation of fat cell differentiation cell differentiation negative regulation of cellular process negative regulation of cell differentiation developmental process fat cell differentiation regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of developmental process biological regulation negative regulation of biological process regulation of cell differentiation negative regulation of fat cell differentiation cell differentiation negative regulation of cellular process negative regulation of cell differentiation cellular process regulation of fat cell differentiation primary metabolic process metabolic process lipid metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle peroxisome microbody

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013154	Alcohol dehydrogenase-like, N-terminal	Domain
A, B	IPR051397	Zinc-containing alcohol dehydrogenase-like protein	Family
A, B	IPR011032	GroES-like superfamily	Homologous Superfamily
A, B	IPR002364	Quinone oxidoreductase/zeta-crystallin, conserved site	Conserved Site
A, B	IPR020843	Polyketide synthase, enoylreductase domain	Domain
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR013149	Alcohol dehydrogenase-like, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8N4Q0	attention deficit hyperactivity disorder, inattentive type cystic fibrosis gastric carcinoma interstitial cystitis malignant glioma ovarian cancer ulcerative colitis atypical teratoid rhabdoid tumor endometrial cancer glioblastoma large cell medulloblastoma medulloblastoma pilocytic astrocytoma colorectal cancer gastric cancer attention deficit hyperactivity disorder, inattentive type cystic fibrosis gastric carcinoma interstitial cystitis malignant glioma ovarian cancer ulcerative colitis atypical teratoid rhabdoid tumor endometrial cancer glioblastoma large cell medulloblastoma medulloblastoma pilocytic astrocytoma colorectal cancer gastric cancer hepatocellular carcinoma malignant ependymoma osteosarcoma subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.