2VZU

Complex of Amycolatopsis orientalis exo-chitosanase CsxA D469A with PNP-beta-D-glucosamine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2vzub2	All beta proteins	Immunoglobulin-like beta-sandwich	beta-Galactosidase/glucuronidase domain	automated matches	automated matches	(Amycolatopsis orientalis ) [TaxId: 31958 ],	SCOPe (2.08)
B	d2vzub1	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	automated matches	automated matches	(Amycolatopsis orientalis ) [TaxId: 31958 ],	SCOPe (2.08)
B	d2vzub3	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	(Trans)glycosidases	automated matches	automated matches	(Amycolatopsis orientalis ) [TaxId: 31958 ],	SCOPe (2.08)
A	d2vzua2	All beta proteins	Immunoglobulin-like beta-sandwich	beta-Galactosidase/glucuronidase domain	automated matches	automated matches	(Amycolatopsis orientalis ) [TaxId: 31958 ],	SCOPe (2.08)
A	d2vzua1	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	automated matches	automated matches	(Amycolatopsis orientalis ) [TaxId: 31958 ],	SCOPe (2.08)
A	d2vzua3	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	(Trans)glycosidases	automated matches	automated matches	(Amycolatopsis orientalis ) [TaxId: 31958 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	beta-Galactosidase/glucuronidase domain-like	8055215	3002047	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	beta-Galactosidase/glucuronidase domain-like	8055466	3002047	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	beta-Galactosidase/glucuronidase domain-like	8055468	3002047	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	(Trans)glycosidases	8037853	3000313	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	galactose-binding domain-like	8037851	3000087	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	(Trans)glycosidases	8037853	3000313	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	beta-Galactosidase/glucuronidase domain-like	8055466	3002047	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	beta-Galactosidase/glucuronidase domain-like	8055468	3002047	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	beta-Galactosidase/glucuronidase domain-like	8055215	3002047	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	galactose-binding domain-like	8037851	3000087	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Glyco_hydro_2_N	e2vzuB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Glyco_hydro_2_N	ECOD (1.6)
B	Glyco_hydro_2	e2vzuB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Glyco_hydro_2	ECOD (1.6)
B	A2M_N_like	e2vzuB4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: A2M_N_like	ECOD (1.6)
B	DUF4232_like	e2vzuB3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: DUF4232_like	ECOD (1.6)
B	Glyco_hydro_2_C	e2vzuB5	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_2_C	ECOD (1.6)
A	Glyco_hydro_2_N	e2vzuA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Glyco_hydro_2_N	ECOD (1.6)
A	Glyco_hydro_2	e2vzuA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Glyco_hydro_2	ECOD (1.6)
A	A2M_N_like	e2vzuA4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: A2M_N_like	ECOD (1.6)
A	DUF4232_like	e2vzuA3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: DUF4232_like	ECOD (1.6)
A	Glyco_hydro_2_C	e2vzuA5	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_2_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00703	Glycosyl hydrolases family 2 (Glyco_hydro_2)	Glycosyl hydrolases family 2	This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.	Domain
A, B	PF18368	Exo-beta-D-glucosaminidase Ig-fold domain (Ig_GlcNase)	Exo-beta-D-glucosaminidase Ig-fold domain	This domain can be found in 2 glycoside hydrolase subfamily of beta-glucosaminidases (EC:3.2.1.165) such as CsxA, from Amycolatopsis orientalis that has exo-beta-D-glucosaminidase (exo-chitosanase) activity. It has an immunoglobulin-like topology [1] ...	This domain can be found in 2 glycoside hydrolase subfamily of beta-glucosaminidases (EC:3.2.1.165) such as CsxA, from Amycolatopsis orientalis that has exo-beta-D-glucosaminidase (exo-chitosanase) activity. It has an immunoglobulin-like topology [1].	Domain
A, B	PF22666	Glycosyl hydrolase 2 galactose-binding domain-like (Glyco_hydro_2_N2)	Glycosyl hydrolase 2 galactose-binding domain-like	This domain is found in a number of proteins belonging to glycosyl hydrolase 2 family [1-5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	EXO-BETA-D-GLUCOSAMINIDASE	binding carbohydrate binding hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity exo-1,4-beta-D-glucosaminidase activity	carbohydrate derivative catabolic process catabolic process carbohydrate derivative metabolic process chitin metabolic process aminoglycan catabolic process macromolecule catabolic process glucosamine-containing compound catabolic process amino sugar catabolic process aminoglycan metabolic process amino sugar metabolic process metabolic process cellular process macromolecule metabolic process chitin catabolic process carbohydrate derivative catabolic process catabolic process carbohydrate derivative metabolic process chitin metabolic process aminoglycan catabolic process macromolecule catabolic process glucosamine-containing compound catabolic process amino sugar catabolic process aminoglycan metabolic process amino sugar metabolic process metabolic process cellular process macromolecule metabolic process chitin catabolic process glucosamine-containing compound metabolic process carbohydrate metabolic process polysaccharide metabolic process polysaccharide catabolic process carbohydrate catabolic process primary metabolic process	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR041351	Exo-beta-D-glucosaminidase, Ig-fold domain	Domain
A, B	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A, B	IPR006102	Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich	Domain
A, B	IPR036156	Beta-Galactosidase/glucuronidase domain superfamily	Homologous Superfamily
A, B	IPR005084	Carbohydrate binding module family 6	Domain
A, B	IPR043534	Exo-beta-D-glucosaminidase/Endo-beta-mannosidase	Family
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR054593	Beta-mannosidase-like, galactose-binding domain-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.