Annotations: 1WZO

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	FAH	8083142	3001446	SCOP2B (2022-06-29)
C	SCOP2 Family	FAH	8083141	4002580	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	FAH	8083142	3001446	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	FAH	8083142	3001446	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	FAH	8083142	3001446	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FAA_hydrolase	e1wzoA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: FAH (From Topology)	T: FAH	F: FAA_hydrolase	ECOD (1.6)
C	FAA_hydrolase	e1wzoC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: FAH (From Topology)	T: FAH	F: FAA_hydrolase	ECOD (1.6)
B	FAA_hydrolase	e1wzoB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: FAH (From Topology)	T: FAH	F: FAA_hydrolase	ECOD (1.6)
D	FAA_hydrolase	e1wzoD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: FAH (From Topology)	T: FAH	F: FAA_hydrolase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.370	Mainly Beta	Roll	SH3 type barrels.	FAH	CATH (4.3.0)
A	3.90.850.10	Alpha Beta	Alpha-Beta Complex	Fumarylacetoacetate hydrolase	domain 2	CATH (4.3.0)
C	2.30.30.370	Mainly Beta	Roll	SH3 type barrels.	FAH	CATH (4.3.0)
C	3.90.850.10	Alpha Beta	Alpha-Beta Complex	Fumarylacetoacetate hydrolase	domain 2	CATH (4.3.0)
B	2.30.30.370	Mainly Beta	Roll	SH3 type barrels.	FAH	CATH (4.3.0)
B	3.90.850.10	Alpha Beta	Alpha-Beta Complex	Fumarylacetoacetate hydrolase	domain 2	CATH (4.3.0)
D	2.30.30.370	Mainly Beta	Roll	SH3 type barrels.	FAH	CATH (4.3.0)
D	3.90.850.10	Alpha Beta	Alpha-Beta Complex	Fumarylacetoacetate hydrolase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01557	Fumarylacetoacetate (FAA) hydrolase family (FAA_hydrolase)	Fumarylacetoacetate (FAA) hydrolase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	HpcE	isomerase activity intramolecular oxidoreductase activity, transposing C=C bonds intramolecular oxidoreductase activity 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity catalytic activity hydrolase activity, acting on acid carbon-carbon bonds hydrolase activity acetylpyruvate hydrolase activity hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances cation binding ion binding binding metal ion binding small molecule binding isomerase activity intramolecular oxidoreductase activity, transposing C=C bonds intramolecular oxidoreductase activity 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity catalytic activity hydrolase activity, acting on acid carbon-carbon bonds hydrolase activity acetylpyruvate hydrolase activity hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances cation binding ion binding binding metal ion binding small molecule binding 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity carboxy-lyase activity lyase activity carbon-carbon lyase activity	4-hydroxyphenylacetate metabolic process catabolic process oxoacid metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process organic acid metabolic process organic acid catabolic process phenol-containing compound catabolic process cellular catabolic process 4-hydroxyphenylacetate catabolic process monocarboxylic acid catabolic process organic hydroxy compound catabolic process carboxylic acid catabolic process phenol-containing compound metabolic process 4-hydroxyphenylacetate metabolic process catabolic process oxoacid metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process organic acid metabolic process organic acid catabolic process phenol-containing compound catabolic process cellular catabolic process 4-hydroxyphenylacetate catabolic process monocarboxylic acid catabolic process organic hydroxy compound catabolic process carboxylic acid catabolic process phenol-containing compound metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process small molecule catabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036663	Fumarylacetoacetase-like, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR012684	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit	Domain
A, B, C, D	IPR011234	Fumarylacetoacetase-like, C-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.