1UPK

Crystal structure of MO25 in complex with a C-terminal peptide of STRAD

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1upka_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Mo25 protein	Mo25 protein	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Mo25 protein	8029583	4000734	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ARM repeat-like	8041962	3000116	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Mo25	e1upkA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Mo25	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	STE-20 RELATED ADAPTOR	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding kinase binding enzyme binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity protein serine/threonine kinase activator activity	protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process nuclear export intracellular protein transport cell cycle G1 to G0 transition cell cycle process regulation of cellular process regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein kinase activity phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of cellular process regulation of biological process protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process biological regulation positive regulation of catalytic activity primary metabolic process regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process	protein-containing complex intracellular protein-containing complex protein kinase complex transferase complex, transferring phosphorus-containing groups catalytic complex serine/threonine protein kinase complex transferase complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen protein-containing complex intracellular protein-containing complex protein kinase complex transferase complex, transferring phosphorus-containing groups catalytic complex serine/threonine protein kinase complex transferase complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
A	MO25 PROTEIN	protein binding binding kinase binding enzyme binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity protein serine/threonine kinase activator activity	regulation of localization regulation of potassium ion transport regulation of cellular process negative regulation of ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport negative regulation of biological process potassium ion transmembrane transport regulation of transmembrane transporter activity negative regulation of transport regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport regulation of localization regulation of potassium ion transport regulation of cellular process negative regulation of ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport negative regulation of biological process potassium ion transmembrane transport regulation of transmembrane transporter activity negative regulation of transport regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport regulation of transporter activity monoatomic cation transmembrane transport localization negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process monoatomic ion transport negative regulation of cation transmembrane transport monoatomic cation transport regulation of metal ion transport regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transport regulation of monoatomic ion transmembrane transporter activity regulation of biological process regulation of transport regulation of monoatomic ion transport biological regulation negative regulation of transporter activity negative regulation of molecular function inorganic ion transmembrane transport negative regulation of potassium ion transmembrane transport regulation of potassium ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport potassium ion transport cellular process regulation of monoatomic cation transmembrane transport response to thyroid hormone response to stimulus response to hormone response to endogenous stimulus response to chemical positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-threonine phosphorylation positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process peptidyl-threonine modification positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of peptidyl-threonine phosphorylation phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process peptidyl-threonine phosphorylation peptidyl-serine modification peptidyl-serine phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of protein serine/threonine kinase activity positive regulation of molecular function positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity response to activity cellular response to stimulus signaling signal transduction intracellular signal transduction cell communication response to osmotic stress cellular hypotonic response cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus hypotonic response cellular response to chemical stimulus cellular response to stress response to stress response to abiotic stimulus cellular response to abiotic stimulus	intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen cytoplasmic vesicle organelle lumen secretory granule secretory vesicle protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex cytosol ficolin-1-rich granule ficolin-1-rich granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B	IPR000719	Protein kinase domain	Domain
B	IPR047173	STE20-related kinase adapter protein alpha/beta-like	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR013878	Mo25-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q7RTN6	medulloblastoma polyhydramnios, megalencephaly, and symptomatic epilepsy adult medulloblastoma childhood medulloblastoma medullomyoblastoma with myogenic differentiation melanotic medulloblastoma Epileptic encephalopathy osteosarcoma hydrocephalus desmoplastic/nodular medulloblastoma intellectual disability
A	Pharos: Q9Y376	atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma hereditary spastic paraplegia lymphoplasmacytic lymphoma ovarian cancer IgA glomerulonephritis medulloblastoma ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.