1TZB

Crystal structure of native phosphoglucose/phosphomannose isomerase from Pyrobaculum aerophilum

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1tzbb_	Alpha and beta proteins (a/b)	SIS domain	SIS domain	double-SIS domain	Glucose-6-phosphate isomerase, conjectural	(Pyrobaculum aerophilum str. IM2 ) [TaxId: 178306 ],	SCOPe (2.08)
A	d1tzba_	Alpha and beta proteins (a/b)	SIS domain	SIS domain	double-SIS domain	Glucose-6-phosphate isomerase, conjectural	(Pyrobaculum aerophilum str. IM2 ) [TaxId: 178306 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8043798	3001397	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8052802	3001397	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8052802	3001397	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8043798	3001397	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	bact-PGI_C	e1tzbB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: bact-PGI_C	ECOD (1.6)
B	SIS	e1tzbB2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: SIS	ECOD (1.6)
A	bact-PGI_C	e1tzbA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: bact-PGI_C	ECOD (1.6)
A	SIS	e1tzbA2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: SIS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.10490	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glucose-6-phosphate isomerase like protein	CATH (4.3.0)
A	3.40.50.10490	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glucose-6-phosphate isomerase like protein	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF10432	Bacterial phospho-glucose isomerase C-terminal SIS domain (bact-PGI_C)	Bacterial phospho-glucose isomerase C-terminal SIS domain	This is the C-terminal SIS domain of a bacterial phospho-glucose isomerase EC:5.3.1.9 protein which is similar to eukaryote homologues to the extent that the sequence includes the cluster of threonines and serines that forms the sugar phosphate-bindi ...	This is the C-terminal SIS domain of a bacterial phospho-glucose isomerase EC:5.3.1.9 protein which is similar to eukaryote homologues to the extent that the sequence includes the cluster of threonines and serines that forms the sugar phosphate-binding site in conventional PGI. This domain contributes a good proportion of the active catalytic site residues. This PGI uses the same catalytic mechanisms for both glucose ring-opening and isomerisation for the interconversion of glucose 6-phosphate to fructose 6-phosphate [1]. It is associated with family SIS, Pfam:PF01380.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	glucose-6-phosphate isomerase, conjectural	isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity mannose-6-phosphate isomerase activity catalytic activity glucose-6-phosphate isomerase activity binding carbohydrate derivative binding	carbohydrate metabolic process primary metabolic process metabolic process cellular process carbohydrate derivative metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR046348	SIS domain superfamily	Homologous Superfamily
A, B	IPR035484	Bifunctional phosphoglucose/phosphomannose isomerase, SIS domain 1	Domain
A, B	IPR019490	Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase, C-terminal	Domain
A, B	IPR001347	SIS domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.