Annotations: 1T8D

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1t8da_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	Low affinity immunoglobulin epsilon Fc receptor	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	C-type lectin domain	8020091	4002453	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	C-type lectin-like	8032471	3001261	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lectin_C	e1t8dA1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Low affinity immunoglobulin epsilon Fc receptor	binding carbohydrate binding cell adhesion molecule binding protein-containing complex binding protein binding integrin binding signaling receptor binding enzyme binding protease binding IgE binding immunoglobulin binding molecular transducer activity immunoglobulin receptor activity transmembrane signaling receptor activity binding carbohydrate binding cell adhesion molecule binding protein-containing complex binding protein binding integrin binding signaling receptor binding enzyme binding protease binding IgE binding immunoglobulin binding molecular transducer activity immunoglobulin receptor activity transmembrane signaling receptor activity signaling receptor activity low-affinity IgE receptor activity immune receptor activity IgE receptor activity pattern recognition receptor activity cation binding ion binding metal ion binding small molecule binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity B cell antigen processing and presentation response to stimulus immune response adaptive immune response immune effector process antigen processing and presentation immune system process B cell mediated immunity leukocyte mediated immunity positive regulation of nitric-oxide synthase activity regulation of molecular function positive regulation of molecular function adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity B cell antigen processing and presentation response to stimulus immune response adaptive immune response immune effector process antigen processing and presentation immune system process B cell mediated immunity leukocyte mediated immunity positive regulation of nitric-oxide synthase activity regulation of molecular function positive regulation of molecular function positive regulation of monooxygenase activity regulation of catalytic activity regulation of nitric-oxide synthase activity biological regulation positive regulation of catalytic activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity localization import into cell Fc receptor-mediated immune complex endocytosis transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport protein-containing complex localization regulation of humoral immune response regulation of immune effector process humoral immune response positive regulation of leukocyte mediated immunity regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of B cell mediated immunity positive regulation of response to stimulus humoral immune response mediated by circulating immunoglobulin positive regulation of humoral immune response regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune response regulation of immunoglobulin mediated immune response regulation of immune system process positive regulation of immune effector process positive regulation of adaptive immune response positive regulation of immune system process positive regulation of immunoglobulin mediated immune response regulation of biological process positive regulation of humoral immune response mediated by circulating immunoglobulin regulation of adaptive immune response immunoglobulin mediated immune response regulation of B cell mediated immunity regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of response to stimulus regulation of immune response macrophage activation multicellular organismal process cell activation myeloid leukocyte activation leukocyte activation cellular response to stimulus immune response-regulating cell surface receptor signaling pathway involved in phagocytosis immune response-regulating cell surface receptor signaling pathway regulation of cellular process signaling Fc-gamma receptor signaling pathway involved in phagocytosis cell communication immune response-activating signaling pathway Fc receptor signaling pathway immune response-regulating signaling pathway phagocytosis signal transduction Fc-gamma receptor signaling pathway cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway Fc receptor mediated stimulatory signaling pathway activation of immune response	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016187	C-type lectin fold	Homologous Superfamily
A	IPR033989	CD209-like, C-type lectin-like domain	Domain
A	IPR001304	C-type lectin-like	Domain
A	IPR018378	C-type lectin, conserved site	Conserved Site
A	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A	IPR050111	C-type lectin and snaclec domain-containing protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P06734	encephalitis HIV infectious disease B-cell chronic lymphocytic leukemia large cell medulloblastoma psoriasis Hypersensitivity, Immediate medulloblastoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.