1SYQ

Human vinculin head domain VH1, residues 1-258, in complex with human talin's vinculin binding site 1, residues 607-636

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1syqa1	All alpha proteins	Four-helical up-and-down bundle	alpha-catenin/vinculin-like	alpha-catenin/vinculin	Vinculin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1syqa3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	alpha-Catenin/Vinculin	8027423	4000832	SCOP2 (2022-06-29)
A	SCOP2 Family	alpha-Catenin/Vinculin	8027424	4000832	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	alpha-Catenin/Vinculin-like	8039802	3001619	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	alpha-Catenin/Vinculin-like	8039803	3001619	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Vinculin_1st	e1syqA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: Vinculin_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.230	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Alpha-catenin/vinculin-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01044	Vinculin family (Vinculin)	Vinculin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	vinculin isoform VCL	protein binding binding alpha-catenin binding cell adhesion molecule binding cadherin binding molecular adaptor activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding dystroglycan binding cytoskeletal protein binding actin binding structural molecule activity beta-catenin binding	regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion biological regulation cell-substrate adhesion regulation of cellular component biogenesis regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization cellular process regulation of focal adhesion assembly regulation of cell-substrate junction assembly cell-cell adhesion epithelial cell-cell adhesion lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly lamellipodium organization cell projection assembly developmental process tissue morphogenesis anatomical structure morphogenesis epithelium development anatomical structure development morphogenesis of an epithelium tissue development multicellular organismal process regulation of body fluid levels wound healing response to stimulus homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation response to stress coagulation regulation of biological quality response to wounding platelet activation apical junction assembly cell-cell junction assembly cell-cell junction organization negative regulation of locomotion regulation of cell motility negative regulation of biological process regulation of locomotion negative regulation of cellular process regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion axon extension axonogenesis cellular developmental process developmental growth plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell growth cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation system development neuron projection extension developmental cell growth growth nervous system development axon development cell morphogenesis involved in neuron differentiation developmental growth involved in morphogenesis generation of neurons neuron development adherens junction organization adherens junction assembly protein localization localization cellular localization protein localization to cell surface cellular macromolecule localization macromolecule localization regulation of localization regulation of protein localization regulation of protein localization to cell-cell junction regulation of protein localization to adherens junction protein localization to adherens junction protein localization to cell-cell junction regulation of cellular localization protein localization to cell junction regulation of establishment of endothelial barrier regulation of developmental process endothelium development regulation of cell differentiation epithelial cell differentiation regulation of cell development regulation of epithelial cell differentiation endothelial cell development regulation of endothelial cell development regulation of multicellular organismal process regulation of multicellular organismal development endothelial cell differentiation regulation of endothelial cell differentiation epithelial cell development establishment of endothelial barrier maintenance of blood-brain barrier multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis	intracellular anatomical structure cell cortex cortical cytoskeleton intracellular membraneless organelle actin cytoskeleton intracellular organelle cell periphery cellular anatomical structure cytoskeleton organelle membraneless organelle cortical actin cytoskeleton terminal web cytoplasm intracellular anatomical structure cell cortex cortical cytoskeleton intracellular membraneless organelle actin cytoskeleton intracellular organelle cell periphery cellular anatomical structure cytoskeleton organelle membraneless organelle cortical actin cytoskeleton terminal web cytoplasm cell-cell junction anchoring junction cell junction extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol sarcolemma plasma membrane membrane costamere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex cluster of actin-based cell projections brush border adherens junction intercalated disc fascia adherens cell-cell contact zone cell-substrate junction desmosome inner dense plaque of desmosome vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen cytoplasmic vesicle organelle lumen specific granule lumen secretory granule secretory vesicle specific granule podosome podosome ring focal adhesion outer dense plaque of desmosome membrane microdomain membrane raft apical junction complex zonula adherens ficolin-1-rich granule ficolin-1-rich granule lumen protein-containing complex cell projection
B	Talin 1	binding phospholipid binding lipid binding phosphatidylinositol binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding cell adhesion molecule binding cadherin binding modified amino acid binding phosphatidylserine binding LIM domain binding binding phospholipid binding lipid binding phosphatidylinositol binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding cell adhesion molecule binding cadherin binding modified amino acid binding phosphatidylserine binding LIM domain binding protein domain specific binding vinculin binding integrin binding signaling receptor binding structural constituent of cytoskeleton structural molecule activity	regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion biological regulation cell-substrate adhesion regulation of cellular component biogenesis regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization cellular process regulation of focal adhesion assembly regulation of cell-substrate junction assembly protein-containing complex organization protein-containing complex assembly integrin activation multicellular organismal process regulation of body fluid levels wound healing response to stimulus homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation cell-cell adhesion response to stress coagulation regulation of biological quality response to wounding platelet activation organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization cell-cell junction assembly cell-cell junction organization cortical actin cytoskeleton organization cortical cytoskeleton organization microtubule cytoskeleton organization cytoplasmic microtubule organization cortical microtubule organization microtubule-based process supramolecular fiber organization cellular response to stimulus integrin-mediated signaling pathway cell surface receptor signaling pathway signaling cell communication signal transduction	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell-cell junction extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell-cell junction adherens junction anchoring junction cell junction intracellular organelle cytoskeleton membraneless organelle intracellular membraneless organelle ruffle cell projection cell leading edge plasma membrane bounded cell projection focal adhesion cell-substrate junction plasma membrane membrane leading edge membrane cell periphery ruffle membrane plasma membrane region cell projection membrane cell surface

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017997	Vinculin	Family
A	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
A	IPR006077	Vinculin/alpha-catenin	Family
A	IPR000633	Vinculin, conserved site	Conserved Site
B	IPR000299	FERM domain	Domain
B	IPR019748	FERM central domain	Domain
B	IPR035963	FERM superfamily, second domain	Homologous Superfamily
B	IPR036476	Talin, central domain superfamily	Homologous Superfamily
B	IPR002558	I/LWEQ domain	Domain
B	IPR019747	FERM conserved site	Conserved Site
B	IPR054060	Talin 1-like, rod-segment domain	Domain
B	IPR049108	Talin, R4 domain	Domain
B	IPR002404	IRS-type PTB domain	Domain
B	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
B	IPR015009	Vinculin-binding site-containing domain	Domain
B	IPR032425	Talin, N-terminal F0 domain	Domain
B	IPR011993	PH-like domain superfamily	Homologous Superfamily
B	IPR035964	I/LWEQ domain superfamily	Homologous Superfamily
B	IPR015224	Talin, central	Domain
B	IPR054082	Talin, IBS2B domain	Domain
B	IPR019749	Band 4.1 domain	Domain
B	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
B	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
B	IPR037438	Talin-1/2, rod-segment	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P18206	dilated cardiomyopathy 1W hypertrophic cardiomyopathy 15 dilated cardiomyopathy osteoporosis acute coronary syndrome cardiomyopathy hypertrophic cardiomyopathy malignant ependymoma ovarian cancer spondyloarthropathy Crohn disease familial isolated dilated cardiomyopathy lung carcinoma malignant pancreatic neoplasm Osteoporosis, Age-Related dilated cardiomyopathy 1W hypertrophic cardiomyopathy 15 dilated cardiomyopathy osteoporosis acute coronary syndrome cardiomyopathy hypertrophic cardiomyopathy malignant ependymoma ovarian cancer spondyloarthropathy Crohn disease familial isolated dilated cardiomyopathy lung carcinoma malignant pancreatic neoplasm Osteoporosis, Age-Related pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma astrocytic tumor Charcot-Marie-Tooth disease diabetes mellitus familial dilated cardiomyopathy glioblastoma inflammatory bowel disease malignant colon neoplasm medulloblastoma tuberculosis atypical teratoid rhabdoid tumor familial hypertrophic cardiomyopathy lung cancer
B	Pharos: Q9Y490	Neoplasm Invasiveness osteoporosis acute myeloid leukemia chronic obstructive pulmonary disease invasive ductal breast carcinoma astrocytic tumor diabetes mellitus malignant ependymoma osteosarcoma psoriasis atypical teratoid rhabdoid tumor glioblastoma malignant glioma pilocytic astrocytoma