Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyAcid proteases 8042430 3001059 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyAcid proteases 8042430 3001059 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BRVPe1mtrB1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: acid proteaseF: RVPECOD (1.6)
ARVPe1mtrA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: acid proteaseF: RVPECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
B2.40.70.10 Mainly Beta Beta Barrel Cathepsin D, subunit A domain 1CATH (4.3.0)
A2.40.70.10 Mainly Beta Beta Barrel Cathepsin D, subunit A domain 1CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00077Retroviral aspartyl protease (RVP)Retroviral aspartyl proteaseSingle domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a ...Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases such as pepsins, cathepsins, and renins (Pfam:PF00026).
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
HIV-1 PROTEASE

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR036397Ribonuclease H superfamilyHomologous Superfamily
A, B
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
A, B
IPR001995Peptidase A2A, retrovirus, catalyticDomain
A, B
IPR001878Zinc finger, CCHC-typeDomain
A, B
IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
A, B
IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
A, B
IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
A, B
IPR018061RetropepsinsDomain
A, B
IPR010661Reverse transcriptase thumbDomain
A, B
IPR002156Ribonuclease H domainDomain
A, B
IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
A, B
IPR003308Integrase, N-terminal zinc-binding domainDomain
A, B
IPR001584Integrase, catalytic coreDomain
A, B
IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
A, B
IPR010999Retroviral matrix proteinHomologous Superfamily
A, B
IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
A, B
IPR001969Aspartic peptidase, active siteActive Site
A, B
IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
A, B
IPR017856Integrase-like, N-terminalHomologous Superfamily
A, B
IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
A, B
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A, B
IPR001037Integrase, C-terminal, retroviralDomain
A, B
IPR034170Retropepsin-like catalytic domainDomain
A, B
IPR000477Reverse transcriptase domainDomain
A, B
IPR010659Reverse transcriptase connectionDomain
A, B
IPR008916Retrovirus capsid, C-terminalHomologous Superfamily

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A, B
ABA Parent Component: ALA

RESIDAA0253 , AA0409

PSI-MOD :  S-(2-aminovinyl)-3-methyl-D-cysteine MOD:00258 , L-2-aminobutanoic acid (Glu) MOD:00819