Annotations: 1K9C

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1k9ca1	All beta proteins	P-domain of calnexin/calreticulin	P-domain of calnexin/calreticulin	P-domain of calnexin/calreticulin	Calreticulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d1k9ca2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	P-domain of calnexin/calreticulin	8042724	3000577	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Calreticulin_2nd_1	e1k9cA1	A: few secondary structure elements	X: P-domain of calnexin/calreticulin (From Topology)	H: P-domain of calnexin/calreticulin (From Topology)	T: P-domain of calnexin/calreticulin	F: Calreticulin_2nd_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.250.10	Mainly Beta	Ribbon	Calnexin lumenal domain, non-globular proline-rich hairpin domain	Calreticulin/calnexin, P domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CALRETICULIN	complement component C1q complex binding opsonin binding protein-containing complex binding protein binding binding complement binding RNA binding organic cyclic compound binding nucleic acid binding mRNA binding cation binding transition metal ion binding iron ion binding ion binding complement component C1q complex binding opsonin binding protein-containing complex binding protein binding binding complement binding RNA binding organic cyclic compound binding nucleic acid binding mRNA binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding molecular sequestering activity hormone binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding calcium ion binding nucleocytoplasmic carrier activity nuclear export signal receptor activity molecular carrier activity carbohydrate binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear androgen receptor binding cell adhesion molecule binding integrin binding signaling receptor binding unfolded protein binding peptide binding	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation response to stimulus response to chemical response to xenobiotic stimulus spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to lithium ion cellular response to lithium ion response to metal ion regulation of protein stability regulation of biological quality protein stabilization response to peptide protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization nuclear export intracellular protein transport catabolic process proteolysis involved in protein catabolic process response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process ERAD pathway cellular response to stress response to stress proteolysis metabolic process protein metabolic process macromolecule metabolic process response to endoplasmic reticulum stress protein folding biosynthetic process gene expression macromolecule biosynthetic process protein maturation regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process regulation of metabolic process positive regulation of cellular process response to ketone response to lipid response to oxygen-containing compound response to testosterone response to organic cyclic compound heart development cardiac muscle tissue development cardiac muscle cell differentiation animal organ development muscle cell differentiation tissue development cardiocyte differentiation striated muscle tissue development circulatory system development muscle structure development striated muscle cell differentiation muscle tissue development regulation of localization import into cell positive regulation of cellular component organization regulation of cellular component organization vesicle-mediated transport cellular component organization positive regulation of endocytosis phagocytosis cellular component organization or biogenesis regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport positive regulation of phagocytosis positive regulation of transport endocytosis positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading cellular senescence organelle organization actin cytoskeleton organization cortical actin cytoskeleton organization cortical cytoskeleton organization actin filament-based process cytoskeleton organization intracellular receptor signaling pathway signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction hormone-mediated signaling pathway intracellular signal transduction negative regulation of cell communication cell communication negative regulation of intracellular steroid hormone receptor signaling pathway cellular response to endogenous stimulus response to hormone regulation of intracellular signal transduction response to steroid hormone regulation of intracellular steroid hormone receptor signaling pathway signal transduction nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus steroid hormone receptor signaling pathway cellular response to hormone stimulus regulation of signaling negative regulation of response to stimulus response to endogenous stimulus cellular response to organic cyclic compound negative regulation of signal transduction regulation of response to stimulus cellular response to lipid regulation of cell communication nuclear receptor-mediated signaling pathway regulation of retinoic acid receptor signaling pathway negative regulation of retinoic acid receptor signaling pathway retinoic acid receptor signaling pathway peptide antigen assembly with MHC class I protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class I protein complex assembly cellular component biogenesis antigen processing and presentation cellular component assembly immune system process protein-containing complex assembly antigen processing and presentation of peptide antigen via MHC class I MHC protein complex assembly antigen processing and presentation of peptide antigen response to electrical stimulus cellular response to electrical stimulus response to abiotic stimulus cellular response to abiotic stimulus cellular response to environmental stimulus RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process regulation of reproductive process meiotic cell cycle process meiotic nuclear division cell cycle regulation of cell cycle cell cycle process regulation of meiotic cell cycle regulation of cell cycle process meiotic cell cycle organelle fission regulation of organelle organization regulation of meiotic nuclear division nuclear division regulation of nuclear division positive regulation of cell cycle post-transcriptional regulation of gene expression negative regulation of translation negative regulation of protein metabolic process regulation of protein metabolic process translation negative regulation of gene expression regulation of translation positive regulation of locomotion regulation of cell motility endothelial cell migration positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration cell motility locomotion positive regulation of dendritic cell chemotaxis regulation of response to external stimulus dendritic cell chemotaxis positive regulation of chemotaxis positive regulation of response to stimulus positive regulation of response to external stimulus taxis positive regulation of mononuclear cell migration regulation of immune system process regulation of mononuclear cell migration positive regulation of immune system process cell chemotaxis chemotaxis regulation of dendritic cell chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration response to external stimulus positive regulation of leukocyte migration positive regulation of leukocyte chemotaxis regulation of chemotaxis leukocyte migration dendritic cell migration mononuclear cell migration leukocyte chemotaxis cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation multi-multicellular organism process negative regulation of locomotion regulation of trophoblast cell migration ameboidal-type cell migration regulation of multicellular organismal process female pregnancy embryo implantation negative regulation of trophoblast cell migration negative regulation of cell migration trophoblast cell migration negative regulation of reproductive process negative regulation of cell motility negative regulation of multicellular organismal process multi-organism reproductive process positive regulation of cell communication positive regulation of signal transduction regulation of non-canonical NF-kappaB signal transduction intracellular signaling cassette non-canonical NF-kappaB signal transduction positive regulation of intracellular signal transduction positive regulation of non-canonical NF-kappaB signal transduction positive regulation of signaling response to biphenyl response to glycoside protein localization to organelle protein localization to nucleus response to estradiol cellular response to virus biological process involved in interspecies interaction between organisms response to other organism response to external biotic stimulus response to virus response to biotic stimulus	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system lytic vacuole cytolytic granule vacuole cytoplasm lysosome extracellular matrix external encapsulating structure collagen-containing extracellular matrix cytosol endoplasmic reticulum smooth endoplasmic reticulum membrane-enclosed lumen sarcoplasmic reticulum lumen intracellular organelle lumen endoplasmic reticulum lumen sarcoplasm organelle lumen sarcoplasmic reticulum synapse cell junction glutamatergic synapse endoplasmic reticulum quality control compartment protein-containing complex MHC class I peptide loading complex organelle subcompartment membrane protein complex endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane perinuclear region of cytoplasm extracellular region extracellular space postsynapse acrosomal vesicle intracellular vesicle cytoplasmic vesicle secretory granule secretory vesicle vesicle cortical granule membraneless organelle intracellular membraneless organelle ribosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR009169	Calreticulin	Family
A	IPR001580	Calreticulin/calnexin	Family
A	IPR018124	Calreticulin/calnexin, conserved site	Conserved Site
A	IPR009033	Calreticulin/calnexin, P domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.