1J8F
HUMAN SIRT2 HISTONE DEACETYLASE
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1j8fa_ | Alpha and beta proteins (a/b) | DHS-like NAD/FAD-binding domain | DHS-like NAD/FAD-binding domain | Sir2 family of transcriptional regulators | Sirt2 histone deacetylase | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
C | d1j8fc_ | Alpha and beta proteins (a/b) | DHS-like NAD/FAD-binding domain | DHS-like NAD/FAD-binding domain | Sir2 family of transcriptional regulators | Sirt2 histone deacetylase | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d1j8fb_ | Alpha and beta proteins (a/b) | DHS-like NAD/FAD-binding domain | DHS-like NAD/FAD-binding domain | Sir2 family of transcriptional regulators | Sirt2 histone deacetylase | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2 Family | Sir2 family of transcriptional regulators | 8021856 | 4003387 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | DHS-like NAD/FAD-binding domain | 8034236 | 3001728 | SCOP2 (2022-06-29) |
C | SCOP2B Superfamily | DHS-like NAD/FAD-binding domain | 8034236 | 3001728 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | DHS-like NAD/FAD-binding domain | 8034236 | 3001728 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | SIR2_1st | e1j8fA2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: DHS-like NAD/FAD-binding domain | F: SIR2_1st | ECOD (1.6) |
A | SIR2_2nd | e1j8fA1 | A: few secondary structure elements | X: Rubredoxin-like | H: Rubredoxin-related | T: Rubredoxin-related | F: SIR2_2nd | ECOD (1.6) |
C | SIR2_1st | e1j8fC1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: DHS-like NAD/FAD-binding domain | F: SIR2_1st | ECOD (1.6) |
C | SIR2_2nd | e1j8fC2 | A: few secondary structure elements | X: Rubredoxin-like | H: Rubredoxin-related | T: Rubredoxin-related | F: SIR2_2nd | ECOD (1.6) |
B | SIR2_1st | e1j8fB2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: DHS-like NAD/FAD-binding domain | F: SIR2_1st | ECOD (1.6) |
B | SIR2_2nd | e1j8fB1 | A: few secondary structure elements | X: Rubredoxin-like | H: Rubredoxin-related | T: Rubredoxin-related | F: SIR2_2nd | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.50.1220 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | TPP-binding domain | CATH (4.3.0) |
A | 3.30.1600.10 | Alpha Beta | 2-Layer Sandwich | SIR2/SIRT2 'Small Domain' | SIR2/SIRT2 'Small Domain' | CATH (4.3.0) |
C | 3.40.50.1220 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | TPP-binding domain | CATH (4.3.0) |
C | 3.30.1600.10 | Alpha Beta | 2-Layer Sandwich | SIR2/SIRT2 'Small Domain' | SIR2/SIRT2 'Small Domain' | CATH (4.3.0) |
B | 3.40.50.1220 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | TPP-binding domain | CATH (4.3.0) |
B | 3.30.1600.10 | Alpha Beta | 2-Layer Sandwich | SIR2/SIRT2 'Small Domain' | SIR2/SIRT2 'Small Domain' | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02146 | Sir2 family (SIR2) | Sir2 family | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR003000 | Sirtuin family | Family | |
IPR029035 | DHS-like NAD/FAD-binding domain superfamily | Homologous Superfamily | |
IPR017328 | Sirtuin, class I | Family | |
IPR026590 | Sirtuin family, catalytic core domain | Domain | |
IPR050134 | NAD-dependent sirtuin protein deacylases | Family | |
IPR026591 | Sirtuin, catalytic core small domain superfamily | Homologous Superfamily |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
Q8IXJ6 | :