1IFQ

Sec22b N-terminal domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ifqa1	Alpha and beta proteins (a+b)	Profilin-like	SNARE-like	Synatpobrevin N-terminal domain	Sec22b	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1ifqa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d1ifqb1	Alpha and beta proteins (a+b)	Profilin-like	SNARE-like	Synatpobrevin N-terminal domain	Sec22b	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d1ifqb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Synaptobrevin N-terminal domain	8021552	4003605	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SNARE-like	8033932	3001113	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	SNARE-like	8033932	3001113	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Longin	e1ifqA1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Longin	ECOD (1.6)
B	Longin	e1ifqB1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Longin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.450.50	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Longin domain	CATH (4.3.0)
B	3.30.450.50	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Longin domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13774	Regulated-SNARE-like domain (Longin)	Regulated-SNARE-like domain	Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex [1]. Longins are the only ...	Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex [1]. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterised by a conserved N-terminal domain with a profilin-like fold called a longin domain [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	vesicle trafficking protein Sec22b	protein binding binding SNARE binding syntaxin binding SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity	localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization establishment of protein localization cellular localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization establishment of protein localization cellular localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization catabolic process regulation of cellular component organization regulation of cellular process macroautophagy autophagy negative regulation of biological process negative regulation of organelle assembly autophagosome organization regulation of autophagy cellular component biogenesis cellular component organization cellular component assembly negative regulation of cellular process cellular component organization or biogenesis process utilizing autophagic mechanism negative regulation of autophagosome assembly negative regulation of catabolic process regulation of biological process autophagosome assembly organelle assembly vacuole organization negative regulation of cellular component organization negative regulation of metabolic process regulation of autophagosome assembly biological regulation regulation of vacuole organization regulation of catabolic process regulation of cellular component biogenesis regulation of organelle organization negative regulation of macroautophagy organelle organization regulation of macroautophagy negative regulation of organelle organization negative regulation of autophagy regulation of organelle assembly metabolic process regulation of metabolic process positive regulation of protein metabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process positive regulation of protein catabolic process positive regulation of catabolic process macromolecule metabolic process regulation of protein catabolic process establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport	membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle COPI-coated vesicle intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle coated vesicle cytoplasm Golgi-associated vesicle vesicle pigment granule membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle COPI-coated vesicle intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle coated vesicle cytoplasm Golgi-associated vesicle vesicle pigment granule melanosome Golgi membrane Golgi apparatus membrane endomembrane system bounding membrane of organelle organelle membrane endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment SNARE complex protein-containing complex membrane protein complex transport vesicle transport vesicle membrane cytoplasmic vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle vesicle membrane ER to Golgi transport vesicle membrane synapse presynapse synaptic vesicle cell junction secretory vesicle exocytic vesicle organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR044565	Vesicle-trafficking protein Sec22	Family
A, B	IPR011012	Longin-like domain superfamily	Homologous Superfamily
A, B	IPR010908	Longin domain	Domain
A, B	IPR001388	Synaptobrevin-like	Family
A, B	IPR042855	v-SNARE, coiled-coil homology domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.