1HX1

CRYSTAL STRUCTURE OF A BAG DOMAIN IN COMPLEX WITH THE HSC70 ATPASE DOMAIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1hx1b1	All alpha proteins	Spectrin repeat-like	BAG domain	BAG domain	BAG-family molecular chaperon regulator-1, BAG1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1hx1b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1hx1a1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	Actin/HSP70	Heat shock protein 70kDa, ATPase fragment	bovine,cow,domestic cattle,domestic cow (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	BAG domain	8020993	4002965	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	BAG domain	8033373	3001951	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	Actin-like ATPases	8044470	3000092	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Actin-like ATPases	8044469	3000092	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	BAG	e1hx1B1	A: alpha bundles	X: Spectrin repeat-like	H: BAG domain (From Topology)	T: BAG domain	F: BAG	ECOD (1.6)
A	HSP70_1st	e1hx1A1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: HSP70_1st	ECOD (1.6)
A	MreB_Mbl_C	e1hx1A2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: MreB_Mbl_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.58.120	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
A	3.30.30.30	Alpha Beta	2-Layer Sandwich	Defensin A-like		CATH (4.3.0)
A	3.90.640.10	Alpha Beta	Alpha-Beta Complex	Actin	Chain A, domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF02179	BAG domain (BAG)	BAG domain	-	Family
A	PF00012	Hsp70 protein (HSP70)	Hsp70 protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	BAG family molecular chaperone regulator 1	molecular function regulator activity adenyl-nucleotide exchange factor activity ATPase regulator activity ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding protein-folding chaperone binding	regulation of biological process regulation of cellular process positive regulation of programmed cell death positive regulation of smooth muscle cell apoptotic process muscle cell apoptotic process smooth muscle cell apoptotic process regulation of apoptotic process biological regulation positive regulation of biological process regulation of muscle cell apoptotic process regulation of programmed cell death cell death regulation of smooth muscle cell apoptotic process positive regulation of apoptotic process positive regulation of muscle cell apoptotic process regulation of biological process regulation of cellular process positive regulation of programmed cell death positive regulation of smooth muscle cell apoptotic process muscle cell apoptotic process smooth muscle cell apoptotic process regulation of apoptotic process biological regulation positive regulation of biological process regulation of muscle cell apoptotic process regulation of programmed cell death cell death regulation of smooth muscle cell apoptotic process positive regulation of apoptotic process positive regulation of muscle cell apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process regulation of protein stability regulation of biological quality protein stabilization cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling signal transduction cell communication chaperone cofactor-dependent protein refolding primary metabolic process gene expression chaperone-mediated protein folding macromolecule biosynthetic process protein maturation protein folding biosynthetic process metabolic process protein metabolic process macromolecule metabolic process 'de novo' protein folding 'de novo' post-translational protein folding negative regulation of programmed cell death negative regulation of biological process negative regulation of apoptotic process negative regulation of cellular process	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
A	Heat shock 70 kDa protein 8	protein binding binding heat shock protein binding ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity protein-macromolecule adaptor activity molecular adaptor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding protein binding binding heat shock protein binding ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity protein-macromolecule adaptor activity molecular adaptor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process protein refolding protein maturation protein folding protein metabolic process cellular component disassembly clathrin coat disassembly transport protein-containing complex organization protein-containing complex disassembly establishment of localization vesicle-mediated transport vesicle uncoating cellular component organization localization cellular component organization or biogenesis protein depolymerization mRNA processing mRNA metabolic process RNA processing RNA splicing protein localization establishment of protein localization cellular localization catabolic process nitrogen compound transport protein targeting to vacuole involved in autophagy protein targeting autophagy establishment of protein localization to vacuole protein targeting to lysosome involved in chaperone-mediated autophagy lysosomal transport macromolecule catabolic process chaperone-mediated autophagy protein targeting to lysosome cellular macromolecule localization establishment of localization in cell process utilizing autophagic mechanism protein targeting to vacuole protein localization to vacuole intracellular transport protein catabolic process protein localization to lysosome establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle vacuolar transport intracellular protein transport chaperone cofactor-dependent protein refolding chaperone-mediated protein folding 'de novo' protein folding 'de novo' post-translational protein folding import into cell synaptic vesicle uncoating synaptic vesicle cycle presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling synaptic vesicle endocytosis endocytosis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen pigment granule intracellular vesicle melanosome cytoplasmic vesicle cytoplasm vesicle protein-containing complex Prp19 complex cytosol cell periphery plasma membrane membrane presynapse synapse cell junction vacuolar membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR003103	BAG domain	Domain
B	IPR000626	Ubiquitin-like domain	Domain
B	IPR036533	BAG domain superfamily	Homologous Superfamily
B	IPR039773	Molecular chaperone regulator BAG	Family
B	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR018181	Heat shock protein 70, conserved site	Conserved Site
A	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A	IPR029048	Heat shock protein 70kD, C-terminal domain superfamily	Homologous Superfamily
A	IPR029047	Heat shock protein 70kD, peptide-binding domain superfamily	Homologous Superfamily
A	IPR013126	Heat shock protein 70 family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q99933	breast carcinoma invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous neoplasm Sjogren syndrome astrocytic tumor breast cancer ductal breast carcinoma in situ malignant mesothelioma Mammary Ductal Carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia spina bifida atypical teratoid rhabdoid tumor interstitial cystitis osteosarcoma breast carcinoma invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous neoplasm Sjogren syndrome astrocytic tumor breast cancer ductal breast carcinoma in situ malignant mesothelioma Mammary Ductal Carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia spina bifida atypical teratoid rhabdoid tumor interstitial cystitis osteosarcoma pancreatic intraductal papillary-mucinous carcinoma schizophrenia swine influenza bipolar disorder depressive disorder malignant pancreatic neoplasm ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.