Annotations: 1FIQ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1fiqb1	Alpha and beta proteins (a+b)	CO dehydrogenase flavoprotein C-domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	Xanthine oxidase, domain 4 (?)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d1fiqb2	Alpha and beta proteins (a+b)	FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein N-terminal domain-like	Xanthine oxidase, domain 3 (?)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d1fiqc1	Alpha and beta proteins (a+b)	alpha/beta-Hammerhead	CO dehydrogenase molybdoprotein N-domain-like	CO dehydrogenase molybdoprotein N-domain-like	Xanthine oxidase, domain 5 (?)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d1fiqc2	Alpha and beta proteins (a+b)	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Xanthine oxidase, C-terminal domain	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A	d1fiqa1	All alpha proteins	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	Xanthine oxidase, domain 2	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A	d1fiqa2	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	Xanthine oxidase, N-terminal domain	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	FAD-binding/transporter-associated domain-like	8043065	3000913	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	CO dehydrogenase flavoprotein C-terminal domain-like	8043061	3001921	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Molybdenum cofactor-binding domain	8043062	3000625	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8043058	3000113	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	CO dehydrogenase ISP C-domain like	8043057	3000439	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	CO_deh_flav_C	e1fiqB1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
B	FAD_binding_5	e1fiqB2	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
C	Ald_Xan_dh_C2	e1fiqC4	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
C	Ald_Xan_dh_C	e1fiqC2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)
A	Fer2_2	e1fiqA1	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
A	Fer2	e1fiqA2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (4.3.0)
B	3.30.465.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 3	CATH (4.3.0)
B	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
C	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
C	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)
A	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
A	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00941	FAD binding domain in molybdopterin dehydrogenase (FAD_binding_5)	FAD binding domain in molybdopterin dehydrogenase	-	Family
B	PF03450	CO dehydrogenase flavoprotein C-terminal domain (CO_deh_flav_C)	CO dehydrogenase flavoprotein C-terminal domain	-	Domain
C	PF01315	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain (Ald_Xan_dh_C)	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	Domain
C	PF20256	Molybdopterin cofactor-binding domain (MoCoBD_2)	Molybdopterin cofactor-binding domain	-	Domain
C	PF02738	Molybdopterin cofactor-binding domain (MoCoBD_1)	Molybdopterin cofactor-binding domain	-	Domain
A	PF01799	[2Fe-2S] binding domain (Fer2_2)	[2Fe-2S] binding domain	-	Domain
A	PF00111	2Fe-2S iron-sulfur cluster binding domain (Fer2)	2Fe-2S iron-sulfur cluster binding domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	XANTHINE OXIDASE	FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity catalytic activity identical protein binding protein binding protein homodimerization activity protein dimerization activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding metal cluster binding cation binding transition metal ion binding iron ion binding metal ion binding molybdenum ion binding molybdopterin cofactor binding oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor xanthine oxidase activity	catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleobase catabolic process nucleobase metabolic process small molecule metabolic process metabolic process catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleobase catabolic process nucleobase metabolic process small molecule metabolic process metabolic process cellular process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle peroxisome microbody cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle peroxisome microbody cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region extracellular space
C	XANTHINE OXIDASE	FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity catalytic activity identical protein binding protein binding protein homodimerization activity protein dimerization activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding metal cluster binding cation binding transition metal ion binding iron ion binding metal ion binding molybdenum ion binding molybdopterin cofactor binding oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor xanthine oxidase activity	catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleobase catabolic process nucleobase metabolic process small molecule metabolic process metabolic process catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleobase catabolic process nucleobase metabolic process small molecule metabolic process metabolic process cellular process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle peroxisome microbody cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle peroxisome microbody cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region extracellular space
A	XANTHINE OXIDASE	FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity catalytic activity identical protein binding protein binding protein homodimerization activity protein dimerization activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding metal cluster binding cation binding transition metal ion binding iron ion binding metal ion binding molybdenum ion binding molybdopterin cofactor binding oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor xanthine oxidase activity	catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleobase catabolic process nucleobase metabolic process small molecule metabolic process metabolic process catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleobase catabolic process nucleobase metabolic process small molecule metabolic process metabolic process cellular process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle peroxisome microbody cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle peroxisome microbody cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR016167	FAD-binding, type PCMH, subdomain 1	Homologous Superfamily
B	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
B	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site	Binding Site
B	IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain	Domain
B	IPR002888	[2Fe-2S]-binding	Domain
B	IPR036318	FAD-binding, type PCMH-like superfamily	Homologous Superfamily
B	IPR016208	Aldehyde oxidase/xanthine dehydrogenase-like	Family
B	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
B	IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily	Homologous Superfamily
B	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
B	IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead	Domain
B	IPR022407	Oxidoreductase, molybdopterin binding site	Binding Site
B	IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily	Homologous Superfamily
B	IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily	Homologous Superfamily
B	IPR016166	FAD-binding domain, PCMH-type	Domain
B	IPR002346	Molybdopterin dehydrogenase, FAD-binding	Domain
B	IPR014307	Xanthine dehydrogenase, small subunit	Domain
B	IPR016169	FAD-binding, type PCMH, subdomain 2	Homologous Superfamily
B	IPR036884	[2Fe-2S]-binding domain superfamily	Homologous Superfamily
B	IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain	Domain
B	IPR005107	CO dehydrogenase flavoprotein, C-terminal	Domain
C	IPR016167	FAD-binding, type PCMH, subdomain 1	Homologous Superfamily
C	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
C	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site	Binding Site
C	IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain	Domain
C	IPR002888	[2Fe-2S]-binding	Domain
C	IPR036318	FAD-binding, type PCMH-like superfamily	Homologous Superfamily
C	IPR016208	Aldehyde oxidase/xanthine dehydrogenase-like	Family
C	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
C	IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily	Homologous Superfamily
C	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
C	IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead	Domain
C	IPR022407	Oxidoreductase, molybdopterin binding site	Binding Site
C	IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily	Homologous Superfamily
C	IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily	Homologous Superfamily
C	IPR016166	FAD-binding domain, PCMH-type	Domain
C	IPR002346	Molybdopterin dehydrogenase, FAD-binding	Domain
C	IPR014307	Xanthine dehydrogenase, small subunit	Domain
C	IPR016169	FAD-binding, type PCMH, subdomain 2	Homologous Superfamily
C	IPR036884	[2Fe-2S]-binding domain superfamily	Homologous Superfamily
C	IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain	Domain
C	IPR005107	CO dehydrogenase flavoprotein, C-terminal	Domain
A	IPR016167	FAD-binding, type PCMH, subdomain 1	Homologous Superfamily
A	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
A	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site	Binding Site
A	IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain	Domain
A	IPR002888	[2Fe-2S]-binding	Domain
A	IPR036318	FAD-binding, type PCMH-like superfamily	Homologous Superfamily
A	IPR016208	Aldehyde oxidase/xanthine dehydrogenase-like	Family
A	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
A	IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily	Homologous Superfamily
A	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
A	IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead	Domain
A	IPR022407	Oxidoreductase, molybdopterin binding site	Binding Site
A	IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily	Homologous Superfamily
A	IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily	Homologous Superfamily
A	IPR016166	FAD-binding domain, PCMH-type	Domain
A	IPR002346	Molybdopterin dehydrogenase, FAD-binding	Domain
A	IPR014307	Xanthine dehydrogenase, small subunit	Domain
A	IPR016169	FAD-binding, type PCMH, subdomain 2	Homologous Superfamily
A	IPR036884	[2Fe-2S]-binding domain superfamily	Homologous Superfamily
A	IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain	Domain
A	IPR005107	CO dehydrogenase flavoprotein, C-terminal	Domain